U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C15H22N2O2
Molecular Weight 262.3474
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of MIXIDINE

SMILES

COC1=CC=C(CCN=C2CCCN2C)C=C1OC

InChI

InChIKey=WRJDCGFHAICFLO-FOCLMDBBSA-N
InChI=1S/C15H22N2O2/c1-17-10-4-5-15(17)16-9-8-12-6-7-13(18-2)14(11-12)19-3/h6-7,11H,4-5,8-10H2,1-3H3/b16-15+

HIDE SMILES / InChI

Molecular Formula C15H22N2O2
Molecular Weight 262.3474
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Mixidine is negative chronotropic agent patented by McNeil Laboratories. Mixidine produced a dose-related decrease in heart rate elevated reflexly by aminophylline, by beta-adrenergic stimulation induced by isoproterenol, by sympathetic nerve stimulation and by intravenous infusion of glucagon. Mixidineattenuated the increase in contractile force produced by sympathetic nerve stimulation but not that induced by isoproterenol. The compound antagonized the increase in the rate of isolated guinea-pig atria induced by both isoproterenol and histamine. In the conscious dog, Mixidine caused no decrease in resting heart rate, mean arterial pressure and cardiac output. It reduced atropine-induced sinus tachycardia as well as that induced by treadmill exercise.

Approval Year

PubMed

PubMed

TitleDatePubMed
Patents

Patents

Substance Class Chemical
Created
by admin
on Sat Dec 16 16:27:00 GMT 2023
Edited
by admin
on Sat Dec 16 16:27:00 GMT 2023
Record UNII
835XO5W69H
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MIXIDINE
INN   USAN  
USAN   INN  
Official Name English
MCN-1589
Code English
2-[(3,4-Dimethoxyphenethyl)imino]-1-methylpyrrolidine
Systematic Name English
mixidine [INN]
Common Name English
BENZENEETHANAMINE, 3,4-DIMETHOXY-N-(1-METHYL-2-PYRROLIDINYLIDENE)-
Systematic Name English
MIXIDINE [USAN]
Common Name English
Code System Code Type Description
INN
3022
Created by admin on Sat Dec 16 16:27:01 GMT 2023 , Edited by admin on Sat Dec 16 16:27:01 GMT 2023
PRIMARY
ChEMBL
CHEMBL75797
Created by admin on Sat Dec 16 16:27:01 GMT 2023 , Edited by admin on Sat Dec 16 16:27:01 GMT 2023
PRIMARY
CAS
27737-38-8
Created by admin on Sat Dec 16 16:27:01 GMT 2023 , Edited by admin on Sat Dec 16 16:27:01 GMT 2023
PRIMARY
FDA UNII
835XO5W69H
Created by admin on Sat Dec 16 16:27:01 GMT 2023 , Edited by admin on Sat Dec 16 16:27:01 GMT 2023
PRIMARY
NCI_THESAURUS
C175145
Created by admin on Sat Dec 16 16:27:01 GMT 2023 , Edited by admin on Sat Dec 16 16:27:01 GMT 2023
PRIMARY
EPA CompTox
DTXSID00865393
Created by admin on Sat Dec 16 16:27:01 GMT 2023 , Edited by admin on Sat Dec 16 16:27:01 GMT 2023
PRIMARY
MESH
C017540
Created by admin on Sat Dec 16 16:27:01 GMT 2023 , Edited by admin on Sat Dec 16 16:27:01 GMT 2023
PRIMARY
EVMPD
SUB09017MIG
Created by admin on Sat Dec 16 16:27:01 GMT 2023 , Edited by admin on Sat Dec 16 16:27:01 GMT 2023
PRIMARY
SMS_ID
100000080883
Created by admin on Sat Dec 16 16:27:01 GMT 2023 , Edited by admin on Sat Dec 16 16:27:01 GMT 2023
PRIMARY
PUBCHEM
34003
Created by admin on Sat Dec 16 16:27:01 GMT 2023 , Edited by admin on Sat Dec 16 16:27:01 GMT 2023
PRIMARY
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SALT/SOLVATE -> PARENT
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ACTIVE MOIETY