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Details

Stereochemistry ACHIRAL
Molecular Formula C10H12N2O8.Ca.2Na
Molecular Weight 374.268
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of EDETATE CALCIUM DISODIUM ANHYDROUS

SMILES

[Na+].[Na+].[Ca++].[O-]C(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O

InChI

InChIKey=SHWNNYZBHZIQQV-UHFFFAOYSA-J
InChI=1S/C10H16N2O8.Ca.2Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;/q;+2;2*+1/p-4

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including https://www.fda.gov/Food/IngredientsPackagingLabeling/GRAS/SCOGS/ucm260884.htm | http://www.webmd.com/drugs/2/drug-159847/calcium-phosphate-dibasic-oral/details

Anhydrous dibasic calcium phosphate is a calcium salt of phosphoric acid. It is used as a diluent in pharmaceutical industry, in some toothpastes as a polishing agent. Calcium phosphate is generally recognized as safe by FDA. Dibasic calcium phosphate is ised as a supplement to treat conditions associated with calcium deficit, such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany)

Originator

Approval Year

1921
1467
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Not Provided
504
Unknown

Approved Use

Unknown
Palliative
Phase I
428
Unknown

Approved Use

Unknown
Palliative
Phase I
428
Unknown

Approved Use

Unknown
Primary
Approved
8429
Unknown

Approved Use

Hypocalcemia, chronic (treatment) — Oral calcium supplements provide a source of calcium ion for treating calcium depletion occurring in conditions such as chronic hypoparathyroidism, pseudohypoparathyroidism, osteomalacia, rickets, chronic renal failure, and hypocalcemia secondary to the administration of anticonvulsant medications. When chronic hypocalcemia is due to vitamin D deficiency, oral calcium salts may be administered concomitantly with vitamin D analogs. However, calcium phosphate should not be used in patients with hypoparathyroidism or renal failure, since phosphate levels may be too high and giving more phosphate would exacerbate the condition. Calcium supplements should not be used in hyperparathyroidism, unless the need for a calcium supplement is high and the patient is carefully monitored. For treatment of hypocalcemia, supplementation is preferred
PubMed

PubMed

TitleDatePubMed
Studies on the calcemic effect of intravenous secretin in humans.
1975 Jun
Regulation of Na/K-ATPase beta1-subunit gene expression by ouabain and other hypertrophic stimuli in neonatal rat cardiac myocytes.
2000 Dec
Effects of a calcimimetic compound and naturally activating mutations on the human Ca2+ receptor and on Ca2+ receptor/metabotropic glutamate chimeric receptors.
2000 Nov
Inhibition of proteolysis by a cyclooxygenase inhibitor, indomethacin.
2000 Nov
Calmodulin kinases II and IV and calcineurin are involved in leukemia inhibitory factor-induced cardiac hypertrophy in rats.
2000 Nov 10
High-calcium diet enhances vasorelaxation in nitric oxide-deficient hypertension.
2000 Sep
Chemokines induce eosinophil degranulation through CCR-3.
2000 Sep
Ca2+-induced contraction of cat esophageal circular smooth muscle cells.
2001 Apr
Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity.
2001 Apr 27
Expression and functional analysis of chemokine receptors in human peripheral blood leukocyte populations.
2001 Apr 7
Metal ion-independent association of factor VIII subunits and the roles of calcium and copper ions for cofactor activity and inter-subunit affinity.
2001 Aug 28
Potent inhibition of NFAT activation and T cell cytokine production by novel low molecular weight pyrazole compounds.
2001 Dec 21
The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel.
2001 Feb 16
Extracellular calcium-sensing receptor is expressed in rat hepatocytes. coupling to intracellular calcium mobilization and stimulation of bile flow.
2001 Feb 9
Functional expression and characterization of a voltage-gated CaV1.3 (alpha1D) calcium channel subunit from an insulin-secreting cell line.
2001 Jul
Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine.
2001 Jul
Endothelin- and sarafotoxin-induced receptor-mediated calcium mobilization in a clonal murine osteoblast-like cell line, MC3T3-E1/B.
2001 Jun
Mechanisms of regulation of agonist efficacy at the 5-HT(1A) receptor by phospholipid-derived signaling components.
2001 Jun
Vasopressin-stimulated Ca2+ spiking in vascular smooth muscle cells involves phospholipase D.
2001 Jun
[Acute renal failure caused by hypercalcemia].
2001 Jun 10
Long-term alteration of calcium homeostatic mechanisms in the pilocarpine model of temporal lobe epilepsy.
2001 Jun 8
Cloning and characterization of a novel human histamine receptor.
2001 Mar
Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H1 receptors.
2001 Mar 15
RGS4 inhibits platelet-activating factor receptor phosphorylation and cellular responses.
2001 Mar 27
Activating mutations of the calcium-sensing receptor: management of hypocalcemia.
2001 Nov
Regression of ventral striatum hypometabolism after calcium/calcitriol therapy in paroxysmal kinesigenic choreoathetosis due to idiopathic primary hypoparathyroidism.
2001 Nov
Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors.
2001 Nov 1
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide.
2001 Oct
Familial intrahepatic cholestasis 1: studies of localization and function.
2001 Oct
Regional differences in functional receptor distribution and calcium mobilization in the intact human lens.
2001 Sep
Effects of vitamin D receptor inactivation on the expression of calbindins and calcium metabolism.
2001 Sep
Cannabinoids attenuate depolarization-dependent Ca2+ influx in intermediate-size primary afferent neurons of adult rats.
2002
The role of endogenous human Trp4 in regulating carbachol-induced calcium oscillations in HEK-293 cells.
2002 Apr 19
Interaction of intravenous anesthetics with recombinant human M1-M3 muscarinic receptors expressed in chinese hamster ovary cells.
2002 Dec
CXCR4 expression on monocytes is up-regulated by dexamethasone and is modulated by autologous CD3+ T cells.
2002 Feb
Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene.
2002 Feb
Characterization of basolateral K+ channels underlying anion secretion in the human airway cell line Calu-3.
2002 Feb 1
Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice.
2002 Jan 15
Characterization of the bone-resorptive effect of interleukin-11 in cultured mouse calvarial bones.
2002 Jul
Delayed asystolic cardiac arrest after diltiazem overdose; resuscitation with high dose intravenous calcium.
2002 Jul
Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor- and calcium-dependent.
2002 Jul 5
Human kidney diamine oxidase: heterologous expression, purification, and characterization.
2002 Jun
Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor.
2002 Mar
Hypertension-related intermyocyte junction remodelling is associated with a higher incidence of low-K(+)-induced lethal arrhythmias in isolated rat heart.
2002 Mar
Diacylglycerol activates the influx of extracellular cations in T-lymphocytes independently of intracellular calcium-store depletion and possibly involving endogenous TRP6 gene products.
2002 May 15
Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit.
2002 Sep
Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors.
2002 Sep 15
Effects of endothelin B receptor agonists on amyloid beta protein (25-35)-induced neuronal cell death.
2002 Sep 6
A critical interplay between Ca2+ inhibition and activation by Mg2+ of AC5 revealed by mutants and chimeric constructs.
2002 Sep 6
Mechanism of enhanced calcium sensitivity and alpha 2-AR vasoreactivity in chronic NOS inhibition hypertension.
2003 Jan
Patents

Patents

03966773
137
03974176
93
03981818
91
04008309
69
04028407
67
04041173
67
04042702
91
04058507
67
04063023
67
06485737
67
06497902
67
08637538
67
20090030026
67
20130174651
67
JP2017071731
67
US2143359
67

Sample Use Guides

In Vivo Use Guide
oral: 500 to 2000 mg elemental calcium a day, in divided doses (bid-qid). inhalation: In a single-blind, phase 1B proof of concept study, 24 subjects were enrolled to sequentially receive three doses of PUR118 (calcium lactate inhalation powder (CLIP) formulation) (5.5 mg, n = 18; 11.0 mg, n = 18; 2.8 mg, n = 16). Each dose was inhaled 3 times (1, 13, 25 h, preceded by 2 puffs salbutamol) before the ozone exposure (250 ppb, 3 h intermittent exercise). Sputum was induced 3 h after the end of exposure.
Route of Administration: Other
In Vitro Use Guide
Unknown
Name Type Language
EDETATE CALCIUM DISODIUM ANHYDROUS
Common Name English
SODIUM CALCIUM EDETATE
EP   INN   JAN   WHO-DD  
INN  
Official Name English
CALCIATE (2-), ((N,N'-1,2-ETHANEDIYLBIS(N-(CARBOXYMETHYL)GLYCINATO))(4-)-N,N',O,O',ON,ON')-, DISODIUM
Common Name English
INS-385
Code English
CALCIATE(2-), ((N,N'-1,2-ETHANEDIYLBIS(N-((CARBOXY- .KAPPA.O)METHYL)GLYCINATO-.KAPPA.N,.KAPPA.O))(4-))-, DISODIUM, (OC-6-21)-
Common Name English
ETHYLENE DIAMINE TETRAACETIC ACID, DISODIUM CALCIUM SALT
Common Name English
CALCIUM DISODIUM EDETATE
GREEN BOOK  
Systematic Name English
CALCIUM TITRIPLEX
Common Name English
CALCIUM DISODIUM ETHYLENE-DIAMINETETRAACETATE
Systematic Name English
CALCIUM DISODIUM EDTA [INCI]
Common Name English
ANTALLIN
Brand Name English
CALCIUM DISODIUM ETHYLENEDIAMINETETRAACETATE
Systematic Name English
SORMETAL
Brand Name English
E-385
Code English
CALCIATE(2-), ((ETHYLENEDINITRILO)TETRAACETATO)-, DISODIUM
Common Name English
CALCIUM DISODIUM EDTA
INCI  
INCI  
Official Name English
LEDCLAIR
Brand Name English
VERSENE CA
Common Name English
INS NO.385
Code English
DETOXAMIN
Common Name English
CALCIUM DISODIUM (ETHYLENEDINITRILO)TETRAACETATE
Systematic Name English
DISODIUM CALCIUM EDTA
Common Name English
MOSATIL
Brand Name English
SODIUM CALCIUM EDETATE [EP MONOGRAPH]
Common Name English
TETAZINE
Common Name English
Sodium calcium edetate [WHO-DD]
Common Name English
CALCIATE(2-), ((N,N'-1,2-ETHANEDIYLBIS(N-((CARBOXY- .KAPPA.O)METHYL)GLYCINATO-.KAPPA.N,.KAPPA.O))(4-))-, SODIUM (1:2), (OC-6-21)-
Common Name English
DISODIUM((ETHYLENEDINITRILO)TETRAACETATO)CALCIATE(2-)
Common Name English
CALCIATE (2-), ((N,N'-1,2-ETHANEDIYLBIS(N-(CARBOXYMETHYL)GLYCINATO))(4-)-N,N',O,O',ON,ON')-, DISODIUM, (OC-6-21)-
Common Name English
NSC-310151
Code English
EDETATE CALCIUM DISODIUM (ANHYDROUS) [HSDB]
Common Name English
EDTA CALCIUM DISODIUM SALT [MI]
Common Name English
CALCIUM DISODIUM EDETATE [GREEN BOOK]
Common Name English
sodium calcium edetate [INN]
Common Name English
ADSORBONAC
Common Name English
EDETAMINE
Common Name English
Classification Tree Code System Code
CFR 21 CFR 176.170
Created by admin on Fri Dec 15 15:29:57 GMT 2023 , Edited by admin on Fri Dec 15 15:29:57 GMT 2023
WHO-ESSENTIAL MEDICINES LIST 4.2
Created by admin on Fri Dec 15 15:29:57 GMT 2023 , Edited by admin on Fri Dec 15 15:29:57 GMT 2023
CFR 21 CFR 172.120
Created by admin on Fri Dec 15 15:29:57 GMT 2023 , Edited by admin on Fri Dec 15 15:29:57 GMT 2023
JECFA EVALUATION INS-385
Created by admin on Fri Dec 15 15:29:57 GMT 2023 , Edited by admin on Fri Dec 15 15:29:57 GMT 2023
NCI_THESAURUS C360
Created by admin on Fri Dec 15 15:29:57 GMT 2023 , Edited by admin on Fri Dec 15 15:29:57 GMT 2023
CODEX ALIMENTARIUS (GSFA) INS-385
Created by admin on Fri Dec 15 15:29:57 GMT 2023 , Edited by admin on Fri Dec 15 15:29:57 GMT 2023
Code System Code Type Description
DRUG BANK
DB00974
Created by admin on Fri Dec 15 15:29:57 GMT 2023 , Edited by admin on Fri Dec 15 15:29:57 GMT 2023
PRIMARY
SMS_ID
100000076472
Created by admin on Fri Dec 15 15:29:57 GMT 2023 , Edited by admin on Fri Dec 15 15:29:57 GMT 2023
PRIMARY
EVMPD
SUB10554MIG
Created by admin on Fri Dec 15 15:29:57 GMT 2023 , Edited by admin on Fri Dec 15 15:29:57 GMT 2023
PRIMARY
EPA CompTox
DTXSID2036409
Created by admin on Fri Dec 15 15:29:57 GMT 2023 , Edited by admin on Fri Dec 15 15:29:57 GMT 2023
PRIMARY
DAILYMED
8U5D034955
Created by admin on Fri Dec 15 15:29:57 GMT 2023 , Edited by admin on Fri Dec 15 15:29:57 GMT 2023
PRIMARY
HSDB
4072
Created by admin on Fri Dec 15 15:29:57 GMT 2023 , Edited by admin on Fri Dec 15 15:29:57 GMT 2023
PRIMARY
CHEBI
4757
Created by admin on Fri Dec 15 15:29:57 GMT 2023 , Edited by admin on Fri Dec 15 15:29:57 GMT 2023
PRIMARY
PUBCHEM
6109
Created by admin on Fri Dec 15 15:29:57 GMT 2023 , Edited by admin on Fri Dec 15 15:29:57 GMT 2023
PRIMARY
INN
305
Created by admin on Fri Dec 15 15:29:57 GMT 2023 , Edited by admin on Fri Dec 15 15:29:57 GMT 2023
PRIMARY
MERCK INDEX
m4835
Created by admin on Fri Dec 15 15:29:57 GMT 2023 , Edited by admin on Fri Dec 15 15:29:57 GMT 2023
PRIMARY Merck Index
CAS
62-33-9
Created by admin on Fri Dec 15 15:29:57 GMT 2023 , Edited by admin on Fri Dec 15 15:29:57 GMT 2023
PRIMARY
FDA UNII
8U5D034955
Created by admin on Fri Dec 15 15:29:57 GMT 2023 , Edited by admin on Fri Dec 15 15:29:57 GMT 2023
PRIMARY
NCI_THESAURUS
C90829
Created by admin on Fri Dec 15 15:29:57 GMT 2023 , Edited by admin on Fri Dec 15 15:29:57 GMT 2023
PRIMARY
ECHA (EC/EINECS)
200-529-9
Created by admin on Fri Dec 15 15:29:57 GMT 2023 , Edited by admin on Fri Dec 15 15:29:57 GMT 2023
PRIMARY
EVMPD
SUB15991MIG
Created by admin on Fri Dec 15 15:29:57 GMT 2023 , Edited by admin on Fri Dec 15 15:29:57 GMT 2023
PRIMARY
WIKIPEDIA
Sodium calcium edetate
Created by admin on Fri Dec 15 15:29:57 GMT 2023 , Edited by admin on Fri Dec 15 15:29:57 GMT 2023
PRIMARY
RXCUI
1371967
Created by admin on Fri Dec 15 15:29:57 GMT 2023 , Edited by admin on Fri Dec 15 15:29:57 GMT 2023
PRIMARY RxNorm
ChEMBL
CHEMBL1200375
Created by admin on Fri Dec 15 15:29:57 GMT 2023 , Edited by admin on Fri Dec 15 15:29:57 GMT 2023
PRIMARY
NSC
310151
Created by admin on Fri Dec 15 15:29:57 GMT 2023 , Edited by admin on Fri Dec 15 15:29:57 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of CALCIUM CATION
PARENT (SALT/SOLVATE)
Structure of EDETIC ACID
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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