DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/8801161
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/8801161
Retonol, also known as Vitamin A1, is a vitamin found in food and used as a dietary supplement. It is used to treat and prevent vitamin A deficiency. It is also used to prevent further issues in those who have measles. Retinol is used as a metabolic precursor of retinoic acid to treat skin-related conditions, such as cellulite, skin aging, photodamage.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2354 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30972178 |
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Target ID: O95237 Gene ID: 9227.0 Gene Symbol: LRAT Target Organism: Homo sapiens (Human) |
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Target ID: Q96NR8 Gene ID: 145226.0 Gene Symbol: RDH12 Target Organism: Homo sapiens (Human) Sources: https://www.drugbank.ca/drugs/DB00162 |
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Target ID: Q92781 Gene ID: 5959.0 Gene Symbol: RDH5 Target Organism: Homo sapiens (Human) Sources: https://www.drugbank.ca/drugs/DB00162 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Preventing | Unknown Approved UseUnknown |
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Preventing | Unknown Approved UseUnknown |
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Preventing | Unknown Approved UseUnknown |
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Primary | AQUASOL A Approved UseUsed to treat and prevent symptoms of vitamin A deficiency such as xerophthalmia and night blindness. Used as a dietary supplement to prevent vitamin A deficiency in patients with GI diseases (e.g., malabsorption syndromes) and those with abnormal storage and transport of vitamin A (e.g., abetalipoproteinemia, protein deficiency, diabetes mellitus, hyperthyroidism, fever, liver disease, cystic fibrosis with hepatic involvement). Launch Date1949 |
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Palliative | AQUASOL A Approved UseChildren with severe measles have been found to have low serum concentrations of vitamin A; WHO and AAP recommend that vitamin A supplements be given to all children with acute measles, regardless of their country of residence. Launch Date1949 |
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Primary | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
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Bilateral transverse sinus obstruction in benign intracranial hypertension due to hypervitaminosis A. | 1978 Aug |
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Vitamin A abuse: development of cirrhosis despite cessation of vitamin A. A six-year clinical and histopathologic follow-up. | 1992 Dec |
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Vitamin neurotoxicity. | 1992 Spring |
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Effects of supplementation with vitamins A, C, and E, selenium, and zinc on immune function in a murine sensitization model. | 2003 Nov-Dec |
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Dietary vitamin A intakes of Filipino elders with adequate or low liver vitamin A concentrations as assessed by the deuterated-retinol-dilution method: implications for dietary requirements. | 2004 Apr |
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Modulation of resistin expression by retinoic acid and vitamin A status. | 2004 Apr |
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Capillary leak syndrome induced by acitretin. | 2004 Jan |
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Safety and efficacy of dose-intensive oral vitamin A in subjects with sun-damaged skin. | 2004 Mar 15 |
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Use of the deuterated-retinol-dilution technique to monitor the vitamin A status of Nicaraguan schoolchildren 1 y after initiation of the Nicaraguan national program of sugar fortification with vitamin A. | 2004 Nov |
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Ocular side effects from herbal medicines and nutritional supplements. | 2004 Oct |
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Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on vitamin A metabolism in mice. | 2005 |
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Protein and m-RNA expression of farnesyl-transferases, RhoA and RhoB in rat liver hepatocytes: action of perillyl alcohol and vitamin A in vivo. | 2005 |
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Alcohol, vitamin A, and cancer. | 2005 Apr |
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Fortification of maize meal improved the nutritional status of 1-3-year-old African children. | 2005 Aug |
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Effects of prenatal vitamins A, E, and C on the hypoplastic hearts of fetal rats with diaphragmatic hernia. | 2005 Aug |
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beta-cryptoxanthin stimulates cell differentiation and mineralization in osteoblastic MC3T3-E1 cells. | 2005 Aug 15 |
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Vitamin A status in mice affects the histone code of the phosphoenolpyruvate carboxykinase gene in liver. | 2005 Dec |
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Phospho-STAT5 accumulation in nuclear fractions from vitamin A-deficient rat liver. | 2005 Jul 4 |
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Effect of vitamin A content in cafeteria diet on the expression of nuclear receptors in rat subcutaneous adipose tissue. | 2005 Jun |
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Vitamin a deficiency and anaemia in young children living in a malaria endemic district of western Kenya. | 2005 Jun |
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Vitamin A deficiency induces prooxidant environment and inflammation in rat aorta. | 2005 Jun |
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Serum and CSF vitamin A concentrations in idiopathic intracranial hypertension. | 2005 Jun 14 |
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Extra-hepatic vitamin A concentrations in captive Rhesus (Macaca mulatta) and Marmoset (Callithrix jacchus) monkeys fed excess vitamin A. | 2005 Mar |
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Megalin-mediated reuptake of retinol in the kidneys of mice is essential for vitamin A homeostasis. | 2005 Nov |
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Expression of nuclear receptor and target genes in liver and intestine of neonatal calves fed colostrum and vitamin A. | 2005 Nov |
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Retinol inhibits the growth of all-trans-retinoic acid-sensitive and all-trans-retinoic acid-resistant colon cancer cells through a retinoic acid receptor-independent mechanism. | 2005 Nov 1 |
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Development of a versatile reporter assay for studies of retinol uptake and metabolism in vivo. | 2005 Nov 1 |
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Retinoid metabolism during development of liver cirrhosis. | 2005 Nov 15 |
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Vitamin A supplementation induces adipose tissue loss through apoptosis in lean but not in obese rats of the WNIN/Ob strain. | 2005 Oct |
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Regulation of a highly specific retinoic acid-4-hydroxylase (CYP26A1) enzyme and all-trans-retinoic acid metabolism in human intestinal, liver, endothelial, and acute promyelocytic leukemia cells. | 2005 Oct |
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Comparison of indices of vitamin A status in children with chronic liver disease. | 2005 Oct |
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Vitamin A regulation of BMP4 expression in the male germ line. | 2005 Oct 1 |
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Acyl coenzyme A dependent retinol esterification by acyl coenzyme A: diacylglycerol acyltransferase 1. | 2005 Oct 15 |
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Retinol induces permeability transition and cytochrome c release from rat liver mitochondria. | 2005 Oct 30 |
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Expression of keratinocyte transglutaminase in cornea of vitamin A-deficient rats. | 2005 Sep |
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Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle. | 2005 Sep 20 |
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Transmembrane protein GDE2 induces motor neuron differentiation in vivo. | 2005 Sep 30 |
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Hypervitaminosis A resulting in DNA aberration in fetal transgenic mice (Muta Mouse). | 2005 Sep 5 |
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Effects of nitrofen and vitamins A, C and E on maturation of cultured human H441 pneumocytes. | 2006 |
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The effect of vitamin A on CCl4-induced hepatic injuries in rats: a histochemical, immunohistochemical and ultrastructural study. | 2006 |
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Vitamin A improves Pax3 expression that is decreased in the heart of rats with experimental diaphragmatic hernia. | 2006 Feb |
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The acute and chronic toxic effects of vitamin A. | 2006 Feb |
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Comparative ligand-binding analysis of ten human lipocalins. | 2006 Feb |
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Retinoic acid regulates sex-specific timing of meiotic initiation in mice. | 2006 Feb 21 |
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RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle. | 2006 Feb 3 |
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Role of retinoic acid receptors alpha1 and gamma in the response of murine limbs to retinol in vitro. | 2006 Jan |
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Renal pathology and retinol status in multiple myeloma patients. | 2006 Jan |
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Expression of Connexin 43 in the hearts of rat embryos exposed to nitrofen and effects of vitamin A on it. | 2006 Jan |
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Vitamin A inhibits pancreatic stellate cell activation: implications for treatment of pancreatic fibrosis. | 2006 Jan |
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Hypervitaminosis A-induced liver fibrosis: stellate cell activation and daily dose consumption. | 2006 Mar |
Patents
Sample Use Guides
The role of vitamin A (2.72 μM/7 ml culture), a naturally occurring antioxidant upon arsenic-induced genotoxicity; with respect to chromosomal aberrations (structural and numerical) and micronuclei. Whole blood cultures set for 72 h were exposed to test chemicals for a period of 24 h ahead of harvesting. Arsenic concentrations tested in the present study are 0.36, 0.72 and 1.4 μM/7 ml culture. Mitomycin C (MMC), the direct acting mutagen was used as positive control.
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NDF-RT |
N0000006269
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CFR |
21 CFR 862.1805
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NDF-RT |
N0000006269
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WHO-ATC |
V04CB01
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DSLD |
3315 (Number of products:1063)
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NDF-RT |
N0000006269
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NDF-RT |
N0000006269
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NDF-RT |
N0000006269
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CFR |
21 CFR 101.78
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FDA ORPHAN DRUG |
546216
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CFR |
21 CFR 184.1930
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WHO-VATC |
QV04CB01
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DSLD |
2698 (Number of products:2377)
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LIVERTOX |
NBK548165
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NDF-RT |
N0000175950
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DSLD |
201 (Number of products:4964)
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234-328-2
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DTXSID301014459
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DB00162
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SUB16102MIG
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Vitamin A
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CHEMBL986
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81G40H8B0T
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11103-57-4
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17616
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11246
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PRIMARY | RxNorm | ||
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VITAMIN A
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SUB05791MIG
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C938
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D014801
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81G40H8B0T
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17336
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VITAMIN A
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PRIMARY | Description: A yellow to brownish yellow, oily liquid.Solubility: Practically insoluble in water; soluble or partly soluble in dehydrated ethanol R; miscible with organic solvents.Category: Vitamin.Storage: The oily form of Retinol concentrate should be kept in a well-closed and well-filled container, protected from light. Oncethe container has been opened its contents should be used as soon as possible; any part of the contents not used at once shouldbe protected by an atmosphere of inert gas.Labelling: The designation on the container should state the name of the retinol ester or esters, and their quantities expressed asthe content of vitamin A in International Units (IU) per gram, whether any stabilizing agents are added and their quantities, as wellas the method of restoring the solution if partial crystallization has occurred.Additional information: Even in the absence of light the oily form of Retinol concentrate is gradually degraded on exposure to ahumid atmosphere, the decomposition being faster at higher temperatures.Partial crystallization may occur in concentrated solutions and upon refrigeration. |
One of these components may be present:
ACTIVE MOIETY