U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C16H22N4O.ClH
Molecular Weight 322.833
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of THONZYLAMINE HYDROCHLORIDE

SMILES

Cl.COC1=CC=C(CN(CCN(C)C)C2=NC=CC=N2)C=C1

InChI

InChIKey=HRYJPHOTGFERGT-UHFFFAOYSA-N
InChI=1S/C16H22N4O.ClH/c1-19(2)11-12-20(16-17-9-4-10-18-16)13-14-5-7-15(21-3)8-6-14;/h4-10H,11-13H2,1-3H3;1H

HIDE SMILES / InChI
Thonzylamine (also known as neohetramine) is an antihistamine and anticholinergic drug, which is used in combination with others compounds for the temporarily relieves symptoms due to the common cold: hay fever (allergic rhinitis) or other upper respiratory allergies: nasal congestion; runny nose and so on. In addition, thonzylamine was investigated for the treatment of tuberculosis, when this drug caused a slight reduction in the extent of tuberculosis in experimentally infected guinea pigs and caused a slight but significant increase in the length of survival.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
NASOPEN PE

Approved Use

Temporarily relieves these symptoms due to the common cold, hay fever (allergic rhinitis) or other upper respiratory allergies: nasal congestion: reduces swelling of the nasal passages, runny nose, sneezing, itching of the nose or throat, itchy, watery eyes

Launch Date

2012
Palliative
NASOPEN PE

Approved Use

Temporarily relieves these symptoms due to the common cold, hay fever (allergic rhinitis) or other upper respiratory allergies: nasal congestion: reduces swelling of the nasal passages, runny nose, sneezing, itching of the nose or throat, itchy, watery eyes

Launch Date

2012
Palliative
NASOPEN PE

Approved Use

Temporarily relieves these symptoms due to the common cold, hay fever (allergic rhinitis) or other upper respiratory allergies: nasal congestion: reduces swelling of the nasal passages, runny nose, sneezing, itching of the nose or throat, itchy, watery eyes

Launch Date

2012
Primary
Unknown

Approved Use

Unknown
Palliative
NASOPEN PE

Approved Use

Temporarily relieves these symptoms due to the common cold, hay fever (allergic rhinitis) or other upper respiratory allergies: nasal congestion: reduces swelling of the nasal passages, runny nose, sneezing, itching of the nose or throat, itchy, watery eyes

Launch Date

2012
PubMed

PubMed

TitleDatePubMed
Adverse drug effects in hospitalized elderly: data from the healthcare cost and utilization project.
2010
Patents

Sample Use Guides

Adults and children 12 years of age and over: 15 mL (1 TBSP) every 4 hours, not to exceed 90 mL (6 TBSP) in a 24 hour period. Children 6 to under 12 years of age: 7.5 mL (1/2 TBSP) every 4 hours, not to exceed 45 mL (3 TBSP) in a 24 hour period.
Route of Administration: Nasal
In Vitro Use Guide
Unknown
Name Type Language
THONZYLAMINE HYDROCHLORIDE
JAN   MART.   MI   USAN   WHO-DD  
USAN  
Official Name English
THONZYLAMINE HYDROCHLORIDE [JAN]
Common Name English
NSC-758388
Code English
2-((2-(DIMETHYLAMINO)ETHYL)(P-METHOXYBENZYL)AMINO)PYRIMIDINE HYDROCHLORIDE
Common Name English
THONZYLAMINE HYDROCHLORIDE [USAN]
Common Name English
THONZYLAMINE HCL
Common Name English
SUPER ANAHIST
Brand Name English
THONZYLAMINE HYDROCHLORIDE [MART.]
Common Name English
THONZYLAMINE HYDROCHLORIDE [MI]
Common Name English
Thonzylamine hydrochloride [WHO-DD]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 341.12
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NCI_THESAURUS C29578
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Code System Code Type Description
NSC
758388
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PRIMARY
DAILYMED
6K9YKD48Y4
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PRIMARY
ECHA (EC/EINECS)
200-561-3
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NCI_THESAURUS
C84205
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MERCK INDEX
m10797
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PRIMARY Merck Index
ChEMBL
CHEMBL1623738
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PRIMARY
CAS
63-56-9
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EVMPD
SUB04825MIG
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EPA CompTox
DTXSID8026147
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MESH
C100145
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SMS_ID
100000084912
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DRUG BANK
DBSALT001562
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PRIMARY
RXCUI
1360720
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PRIMARY RxNorm
FDA UNII
6K9YKD48Y4
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PRIMARY
PUBCHEM
6136
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PRIMARY