MEGLUMINE IOXITHALAMATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C12H11I3N2O5.C7H17NO5
Molecular Weight	839.1531
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CC(=O)NC1=C(I)C(C(=O)NCCO)=C(I)C(C(O)=O)=C1I

InChI

InChIKey=IFTFXKNYTWAOGK-WZTVWXICSA-N

InChI=1S/C12H11I3N2O5.C7H17NO5/c1-4(19)17-10-8(14)5(11(20)16-2-3-18)7(13)6(9(10)15)12(21)22;1-8-2-4(10)6(12)7(13)5(11)3-9/h18H,2-3H2,1H3,(H,16,20)(H,17,19)(H,21,22);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1

HIDE SMILES / InChI

Description
Sources: http://www.pharmaline.co.il/images/newsletterregistration/neopharm/23122011/telebrix35dr.pdf | http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/19112012/telebrix12dr.pdf | http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/16112012/telebrixdr.pdf

Ioxitalamic acid is a contrast media, which was used as a meglumine salt under the name Telebrix for intravenous urography; computed tomography; digital angiography; angiocardiography (ventriculography, coronary angiography). The drug is no longer available on the market.

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Urinary system disease 13 Sources: http://www.pharmaline.co.il/images/newsletterregistration/neopharm/23122011/telebrix35dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/19112012/telebrix12dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/16112012/telebrixdr.pdf	Diagnostic	Approved 8429	TELEBRIX Approved Use This medicinal product is for diagnostic use only. Contrast agent to be used for: intravenous urography; computed tomography; digital angiography; angiocardiography (ventriculography, coronary angiography).
Cerebrovascular diseases 9 Sources: http://www.pharmaline.co.il/images/newsletterregistration/neopharm/23122011/telebrix35dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/19112012/telebrix12dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/16112012/telebrixdr.pdf	Diagnostic	Approved 8429	TELEBRIX Approved Use This medicinal product is for diagnostic use only. Contrast agent to be used for: intravenous urography; computed tomography; digital angiography; angiocardiography (ventriculography, coronary angiography).
Cardiovascular diseases 71 Sources: http://www.pharmaline.co.il/images/newsletterregistration/neopharm/23122011/telebrix35dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/19112012/telebrix12dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/16112012/telebrixdr.pdf	Diagnostic	Approved 8429	TELEBRIX Approved Use This medicinal product is for diagnostic use only. Contrast agent to be used for: intravenous urography; computed tomography; digital angiography; angiocardiography (ventriculography, coronary angiography).

PubMed

Title	Date	PubMed
N-acetylcysteine attenuates iodine contrast agent-induced nephropathy in 5/6-nephrectomized rats.	2010	20502036
Ioxitalamate induces renal tubular apoptosis via activation of renal efferent nerve-mediated adrenergic signaling, renin activity, and reactive oxygen species production in rats.	2010 Mar	19945959

Patents

Sample Use Guides

In Vivo Use Guide

The recommended doses are 1.0 ml/kg (Intravenous urography); 1 and 1.8 ml/kg (computed tomography of brain and computed tomography of the whole body, respectively); 40 ml (ventriculography); 4-8 ml (coronary angiography). The solution for injection contains 350 mg iode/ml.

Route of Administration: Intravenous

In Vitro Use Guide

Ioxitalamic acid was added to human basophils and mast cells isolated from lung, skin, and heart tissue at concentration of 0.1 to 0.5 mol/L (Telebrix preparation). The drug induced histamine release from basophils and histamine and tryptase release from human heart mast cells.

Name

Type

Language

MEGLUMINE IOXITHALAMATE

Common Name

English

IOXITHALAMATE METHYLGLUCAMINE

Common Name

English

IOXITALAMATE MEGLUMINE

Common Name

English

Ioxitalamate meglumine [WHO-DD]

Common Name

English

D-GLUCITOL, 1-DEOXY-1-(METHYLAMINO)-, 5-ACETAMIDO-N-(2-HYDROXYETHYL)- 2,4,6-TRIIODOISOPHTHALAMATE (SALT)

Common Name

English

MEGLUMINE IOXITALAMATE

Common Name

English

Code System Code Type Description

FDA UNII

5791GC9HSW