MEGLUMINE IOXITHALAMATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C12H11I3N2O5.C7H17NO5
Molecular Weight	839.1531
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CC(=O)NC1=C(I)C(C(=O)NCCO)=C(I)C(C(O)=O)=C1I

InChI

InChIKey=IFTFXKNYTWAOGK-WZTVWXICSA-N

InChI=1S/C12H11I3N2O5.C7H17NO5/c1-4(19)17-10-8(14)5(11(20)16-2-3-18)7(13)6(9(10)15)12(21)22;1-8-2-4(10)6(12)7(13)5(11)3-9/h18H,2-3H2,1H3,(H,16,20)(H,17,19)(H,21,22);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1

HIDE SMILES / InChI

Molecular Formula	C7H17NO5
Molecular Weight	195.2136
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	C12H11I3N2O5
Molecular Weight	643.9396
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.pharmaline.co.il/images/newsletterregistration/neopharm/23122011/telebrix35dr.pdf | http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/19112012/telebrix12dr.pdf | http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/16112012/telebrixdr.pdf

Ioxitalamic acid is a contrast media, which was used as a meglumine salt under the name Telebrix for intravenous urography; computed tomography; digital angiography; angiocardiography (ventriculography, coronary angiography). The drug is no longer available on the market.

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Urinary system disease 13 Sources: http://www.pharmaline.co.il/images/newsletterregistration/neopharm/23122011/telebrix35dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/19112012/telebrix12dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/16112012/telebrixdr.pdf	Diagnostic	Approved 8429	TELEBRIX Approved Use This medicinal product is for diagnostic use only. Contrast agent to be used for: intravenous urography; computed tomography; digital angiography; angiocardiography (ventriculography, coronary angiography).
Cerebrovascular diseases 9 Sources: http://www.pharmaline.co.il/images/newsletterregistration/neopharm/23122011/telebrix35dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/19112012/telebrix12dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/16112012/telebrixdr.pdf	Diagnostic	Approved 8429	TELEBRIX Approved Use This medicinal product is for diagnostic use only. Contrast agent to be used for: intravenous urography; computed tomography; digital angiography; angiocardiography (ventriculography, coronary angiography).
Cardiovascular diseases 71 Sources: http://www.pharmaline.co.il/images/newsletterregistration/neopharm/23122011/telebrix35dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/19112012/telebrix12dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/16112012/telebrixdr.pdf	Diagnostic	Approved 8429	TELEBRIX Approved Use This medicinal product is for diagnostic use only. Contrast agent to be used for: intravenous urography; computed tomography; digital angiography; angiocardiography (ventriculography, coronary angiography).

PubMed

Title	Date	PubMed
N-acetylcysteine attenuates iodine contrast agent-induced nephropathy in 5/6-nephrectomized rats.	2010	20502036

Patents

Sample Use Guides

In Vivo Use Guide

The recommended doses are 1.0 ml/kg (Intravenous urography); 1 and 1.8 ml/kg (computed tomography of brain and computed tomography of the whole body, respectively); 40 ml (ventriculography); 4-8 ml (coronary angiography). The solution for injection contains 350 mg iode/ml.

Route of Administration: Intravenous

In Vitro Use Guide

Ioxitalamic acid was added to human basophils and mast cells isolated from lung, skin, and heart tissue at concentration of 0.1 to 0.5 mol/L (Telebrix preparation). The drug induced histamine release from basophils and histamine and tryptase release from human heart mast cells.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:17:56 GMT 2023` Edited by `admin` on `Fri Dec 15 15:17:56 GMT 2023`
Record UNII	5791GC9HSW
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MEGLUMINE IOXITHALAMATE

Common Name

English

IOXITHALAMATE METHYLGLUCAMINE

Common Name

English

IOXITALAMATE MEGLUMINE

Common Name

English

Ioxitalamate meglumine [WHO-DD]

Common Name

English

D-GLUCITOL, 1-DEOXY-1-(METHYLAMINO)-, 5-ACETAMIDO-N-(2-HYDROXYETHYL)- 2,4,6-TRIIODOISOPHTHALAMATE (SALT)

Common Name

English

MEGLUMINE IOXITALAMATE

Common Name

English

Code System Code Type Description

FDA UNII

5791GC9HSW