IOXITALAMIC ACID

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H11I3N2O5
Molecular Weight	643.9396
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)NC1=C(I)C(C(O)=O)=C(I)C(C(=O)NCCO)=C1I

InChI

InChIKey=OLAOYPRJVHUHCF-UHFFFAOYSA-N

InChI=1S/C12H11I3N2O5/c1-4(19)17-10-8(14)5(11(20)16-2-3-18)7(13)6(9(10)15)12(21)22/h18H,2-3H2,1H3,(H,16,20)(H,17,19)(H,21,22)

HIDE SMILES / InChI

Molecular Formula	C12H11I3N2O5
Molecular Weight	643.9396
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.pharmaline.co.il/images/newsletterregistration/neopharm/23122011/telebrix35dr.pdf | http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/19112012/telebrix12dr.pdf | http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/16112012/telebrixdr.pdf

Ioxitalamic acid is a contrast media, which was used as a meglumine salt under the name Telebrix for intravenous urography; computed tomography; digital angiography; angiocardiography (ventriculography, coronary angiography). The drug is no longer available on the market.

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Urinary system disease 13 Sources: http://www.pharmaline.co.il/images/newsletterregistration/neopharm/23122011/telebrix35dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/19112012/telebrix12dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/16112012/telebrixdr.pdf	Diagnostic	Approved 8429	TELEBRIX Approved Use This medicinal product is for diagnostic use only. Contrast agent to be used for: intravenous urography; computed tomography; digital angiography; angiocardiography (ventriculography, coronary angiography).
Cerebrovascular diseases 9 Sources: http://www.pharmaline.co.il/images/newsletterregistration/neopharm/23122011/telebrix35dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/19112012/telebrix12dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/16112012/telebrixdr.pdf	Diagnostic	Approved 8429	TELEBRIX Approved Use This medicinal product is for diagnostic use only. Contrast agent to be used for: intravenous urography; computed tomography; digital angiography; angiocardiography (ventriculography, coronary angiography).
Cardiovascular diseases 71 Sources: http://www.pharmaline.co.il/images/newsletterregistration/neopharm/23122011/telebrix35dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/19112012/telebrix12dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/16112012/telebrixdr.pdf	Diagnostic	Approved 8429	TELEBRIX Approved Use This medicinal product is for diagnostic use only. Contrast agent to be used for: intravenous urography; computed tomography; digital angiography; angiocardiography (ventriculography, coronary angiography).

PubMed

Title	Date	PubMed
Telebrix: a better-tasting oral contrast agent for abdominal computed tomography.	1991 Apr	2039963
N-acetylcysteine attenuates iodine contrast agent-induced nephropathy in 5/6-nephrectomized rats.	2010	20502036
Ioxitalamate induces renal tubular apoptosis via activation of renal efferent nerve-mediated adrenergic signaling, renin activity, and reactive oxygen species production in rats.	2010 Mar	19945959
Do intravenous N-acetylcysteine and sodium bicarbonate prevent high osmolal contrast-induced acute kidney injury? A randomized controlled trial.	2014	25254489

Patents

Sample Use Guides

In Vivo Use Guide

The recommended doses are 1.0 ml/kg (Intravenous urography); 1 and 1.8 ml/kg (computed tomography of brain and computed tomography of the whole body, respectively); 40 ml (ventriculography); 4-8 ml (coronary angiography). The solution for injection contains 350 mg iode/ml.

Route of Administration: Intravenous

In Vitro Use Guide

Ioxitalamic acid was added to human basophils and mast cells isolated from lung, skin, and heart tissue at concentration of 0.1 to 0.5 mol/L (Telebrix preparation). The drug induced histamine release from basophils and histamine and tryptase release from human heart mast cells.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:25:10 GMT 2023` Edited by `admin` on `Fri Dec 15 16:25:10 GMT 2023`
Record UNII	967RDI7Z6K
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IOXITALAMIC ACID

Official Name

English

Ioxitalamic acid [WHO-DD]

Common Name

English

AG 58107

Code

English

AG-58107

Code

English

IOXITHALAMIC ACID

Common Name

English

ioxitalamic acid [INN]

Common Name

English

IOXITALAMIC ACID [MART.]

Common Name

English

5-ACETAMIDO-N-(2-HYDROXYETHYL)-2,4,6-TRIIODOISOPHTHALAMIC ACID

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28500