IOXITALAMIC ACID

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H11I3N2O5
Molecular Weight	643.9396
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)NC1=C(I)C(C(O)=O)=C(I)C(C(=O)NCCO)=C1I

InChI

InChIKey=OLAOYPRJVHUHCF-UHFFFAOYSA-N

InChI=1S/C12H11I3N2O5/c1-4(19)17-10-8(14)5(11(20)16-2-3-18)7(13)6(9(10)15)12(21)22/h18H,2-3H2,1H3,(H,16,20)(H,17,19)(H,21,22)

HIDE SMILES / InChI

Molecular Formula	C12H11I3N2O5
Molecular Weight	643.9396
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.pharmaline.co.il/images/newsletterregistration/neopharm/23122011/telebrix35dr.pdf | http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/19112012/telebrix12dr.pdf | http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/16112012/telebrixdr.pdf

Ioxitalamic acid is a contrast media, which was used as a meglumine salt under the name Telebrix for intravenous urography; computed tomography; digital angiography; angiocardiography (ventriculography, coronary angiography). The drug is no longer available on the market.

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Urinary system disease 13 Sources: http://www.pharmaline.co.il/images/newsletterregistration/neopharm/23122011/telebrix35dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/19112012/telebrix12dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/16112012/telebrixdr.pdf	Diagnostic	Approved 8429	TELEBRIX Approved Use This medicinal product is for diagnostic use only. Contrast agent to be used for: intravenous urography; computed tomography; digital angiography; angiocardiography (ventriculography, coronary angiography).
Cerebrovascular diseases 9 Sources: http://www.pharmaline.co.il/images/newsletterregistration/neopharm/23122011/telebrix35dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/19112012/telebrix12dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/16112012/telebrixdr.pdf	Diagnostic	Approved 8429	TELEBRIX Approved Use This medicinal product is for diagnostic use only. Contrast agent to be used for: intravenous urography; computed tomography; digital angiography; angiocardiography (ventriculography, coronary angiography).
Cardiovascular diseases 71 Sources: http://www.pharmaline.co.il/images/newsletterregistration/neopharm/23122011/telebrix35dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/19112012/telebrix12dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/16112012/telebrixdr.pdf	Diagnostic	Approved 8429	TELEBRIX Approved Use This medicinal product is for diagnostic use only. Contrast agent to be used for: intravenous urography; computed tomography; digital angiography; angiocardiography (ventriculography, coronary angiography).

PubMed

Title	Date	PubMed
Telebrix: a better-tasting oral contrast agent for abdominal computed tomography.	1991 Apr	2039963
Telebrix Gastro in the management of adhesive small bowel obstruction.	2005 May	15980741
N-acetylcysteine attenuates iodine contrast agent-induced nephropathy in 5/6-nephrectomized rats.	2010	20502036
CT colonography with limited bowel preparation for the detection of colorectal neoplasia in an FOBT positive screening population.	2010 Dec	19888629
Ioxitalamate induces renal tubular apoptosis via activation of renal efferent nerve-mediated adrenergic signaling, renin activity, and reactive oxygen species production in rats.	2010 Mar	19945959
Computed microtomography visualization and quantification of mouse ischemic brain lesion by nonionic radio contrast agents.	2013 Feb	23444240
Do intravenous N-acetylcysteine and sodium bicarbonate prevent high osmolal contrast-induced acute kidney injury? A randomized controlled trial.	2014	25254489
Resveratrol alleviates the cytotoxicity induced by the radiocontrast agent, ioxitalamate, by reducing the production of reactive oxygen species in HK-2 human renal proximal tubule epithelial cells in vitro.	2016 Jan	26573558

Patents

Sample Use Guides

In Vivo Use Guide

The recommended doses are 1.0 ml/kg (Intravenous urography); 1 and 1.8 ml/kg (computed tomography of brain and computed tomography of the whole body, respectively); 40 ml (ventriculography); 4-8 ml (coronary angiography). The solution for injection contains 350 mg iode/ml.

Route of Administration: Intravenous

In Vitro Use Guide

Ioxitalamic acid was added to human basophils and mast cells isolated from lung, skin, and heart tissue at concentration of 0.1 to 0.5 mol/L (Telebrix preparation). The drug induced histamine release from basophils and histamine and tryptase release from human heart mast cells.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:25:10 GMT 2023` Edited by `admin` on `Fri Dec 15 16:25:10 GMT 2023`
Record UNII	967RDI7Z6K
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

IOXITALAMIC ACID

Official Name

English

Ioxitalamic acid [WHO-DD]

Common Name

English

AG 58107

Code

English

AG-58107

Code

English

IOXITHALAMIC ACID

Common Name

English

ioxitalamic acid [INN]

Common Name

English

IOXITALAMIC ACID [MART.]

Common Name

English

5-ACETAMIDO-N-(2-HYDROXYETHYL)-2,4,6-TRIIODOISOPHTHALAMIC ACID

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28500