Crizotinib

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H22Cl2FN5O
Molecular Weight	450.337
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@@H](OC1=CC(=CN=C1N)C2=CN(N=C2)C3CCNCC3)C4=C(Cl)C=CC(F)=C4Cl

InChI

InChIKey=KTEIFNKAUNYNJU-GFCCVEGCSA-N

InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1

HIDE SMILES / InChI

Description
Sources: http://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm376058.htm?source=govdelivery&utm_medium=email&utm_source=govdeliveryhttps://www.ncbi.nlm.nih.gov/pubmed/24695225
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/202570s006lbl.pdf; https://www.mskcc.org/cancer-care/clinical-trials/14-063

(S)-crizotinib was discovered as an attractive chemical entity for further pre-clinical evaluation, and small-molecule inhibitors of MTH1 as a promising novel class of anticancer agents.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
ALK tyrosine kinase receptor 25 Target ID: CHEMBL4247 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/202570s006lbl.pdf	Inhibitor 8297	24.0 nM [IC50]
Hepatocyte growth factor receptor 54 Target ID: CHEMBL3717 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/202570s006lbl.pdf	Inhibitor 8297	11.0 nM [IC50]
7,8-dihydro-8-oxoguanine triphosphatase 4 Target ID: P36639 Gene ID: 4521.0 Gene Symbol: NUDT1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/24695225	Inhibitor 8297	72.0 nM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Metastatic non-small cell lung cancer 13 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/202570s000lbl.pdf	Primary		Approved 8429	XALKORI Approved Use Indicated for the treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors are anaplastic lymphoma kinase (ALK)-positive as detected by an FDA-approved test. Launch Date 2011
Cancer 592 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24695225	Primary		Basic research	Unknown Approved Use Unknown

C_max

Value	Dose	Analyte	Population
475 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31778074	300 mg 2 times / day steady-state, oral dose: 300 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	CRIZOTINIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
99.6 ng/mL EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/24990113	250 mg single, oral dose: 250 mg route of administration: Oral experiment type: SINGLE co-administered:	CRIZOTINIB plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
328 ng/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	250 mg 2 times / day steady-state, oral dose: 250 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	CRIZOTINIB unknown	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
327 ng/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	250 mg 2 times / day multiple, oral dose: 250 mg route of administration: Oral experiment type: MULTIPLE co-administered:	CRIZOTINIB unknown	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
87 ng/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	250 mg single, oral dose: 250 mg route of administration: Oral experiment type: SINGLE co-administered:	CRIZOTINIB unknown	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Analyte	Population
3240 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31778074	300 mg 2 times / day steady-state, oral dose: 300 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	CRIZOTINIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
2321 ng × h/mL EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/24990113	250 mg single, oral dose: 250 mg route of administration: Oral experiment type: SINGLE co-administered:	CRIZOTINIB plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
3054 ng × h/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	250 mg 2 times / day steady-state, oral dose: 250 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	CRIZOTINIB unknown	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
3084 ng × h/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	250 mg 2 times / day multiple, oral dose: 250 mg route of administration: Oral experiment type: MULTIPLE co-administered:	CRIZOTINIB unknown	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
1817 ng × h/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	250 mg single, oral dose: 250 mg route of administration: Oral experiment type: SINGLE co-administered:	CRIZOTINIB unknown	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
29 h EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/24990113	250 mg single, oral dose: 250 mg route of administration: Oral experiment type: SINGLE co-administered:		CRIZOTINIB plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
47.1 h DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	250 mg single, oral dose: 250 mg route of administration: Oral experiment type: SINGLE co-administered:		CRIZOTINIB unknown	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

F_unbound

Value	Dose	Co-administered	Analyte	Population
9.3% DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000PharmR.pdf			CRIZOTINIB plasma	Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN

Doses

Dose	Population	Adverse events
300 mg 2 times / day steady, oral Dose: 300 mg, 2 times / day Route: oral Route: steady Dose: 300 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/31778074	unhealthy, 49 years n = 6 Health Status: unhealthy Age Group: 49 years Sex: M+F Population Size: 6 Sources: https://pubmed.ncbi.nlm.nih.gov/31778074	Disc. AE: Fatigue... AEs leading to discontinuation/dose reduction: Fatigue (grade 3, 1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/31778074
250 mg 2 times / day steady, oral Recommended\|MTD Dose: 250 mg, 2 times / day Route: oral Route: steady Dose: 250 mg, 2 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000MedR.pdf	unhealthy, 51 years (range: 21-79 years) n = 119 Health Status: unhealthy Condition: Adenocarcinoma \| Squamous Cell Carcinoma \|Non-small Cell Lung Cancer Age Group: 51 years (range: 21-79 years) Sex: M+F Population Size: 119 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000MedR.pdf	Disc. AE: Autoimmune thyroiditis... AEs leading to discontinuation/dose reduction: Autoimmune thyroiditis (1 patient) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000MedR.pdf
250 mg 2 times / day steady, oral Recommended\|MTD Dose: 250 mg, 2 times / day Route: oral Route: steady Dose: 250 mg, 2 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000MedR.pdf	unhealthy, 52 years (range: 29-82 years) n = 136 Health Status: unhealthy Condition: Adenocarcinoma \| Adenosquamous Carcinoma\|Non-small Cell Lung Cancer Age Group: 52 years (range: 29-82 years) Sex: M+F Population Size: 136 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000MedR.pdf	Disc. AE: ALT increased, Pneumonitis... AEs leading to discontinuation/dose reduction: ALT increased (2.2%) Pneumonitis (1.5%) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000MedR.pdf

AEs

AE	Significance	Dose	Population
Fatigue	grade 3, 1 patient Disc. AE	300 mg 2 times / day steady, oral Dose: 300 mg, 2 times / day Route: oral Route: steady Dose: 300 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/31778074	unhealthy, 49 years n = 6 Health Status: unhealthy Age Group: 49 years Sex: M+F Population Size: 6 Sources: https://pubmed.ncbi.nlm.nih.gov/31778074
Autoimmune thyroiditis	1 patient Disc. AE	250 mg 2 times / day steady, oral Recommended\|MTD Dose: 250 mg, 2 times / day Route: oral Route: steady Dose: 250 mg, 2 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000MedR.pdf	unhealthy, 51 years (range: 21-79 years) n = 119 Health Status: unhealthy Condition: Adenocarcinoma \| Squamous Cell Carcinoma \|Non-small Cell Lung Cancer Age Group: 51 years (range: 21-79 years) Sex: M+F Population Size: 119 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000MedR.pdf
Pneumonitis	1.5% Disc. AE	250 mg 2 times / day steady, oral Recommended\|MTD Dose: 250 mg, 2 times / day Route: oral Route: steady Dose: 250 mg, 2 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000MedR.pdf	unhealthy, 52 years (range: 29-82 years) n = 136 Health Status: unhealthy Condition: Adenocarcinoma \| Adenosquamous Carcinoma\|Non-small Cell Lung Cancer Age Group: 52 years (range: 29-82 years) Sex: M+F Population Size: 136 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000MedR.pdf
ALT increased	2.2% Disc. AE	250 mg 2 times / day steady, oral Recommended\|MTD Dose: 250 mg, 2 times / day Route: oral Route: steady Dose: 250 mg, 2 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000MedR.pdf	unhealthy, 52 years (range: 29-82 years) n = 136 Health Status: unhealthy Condition: Adenocarcinoma \| Adenosquamous Carcinoma\|Non-small Cell Lung Cancer Age Group: 52 years (range: 29-82 years) Sex: M+F Population Size: 136 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000MedR.pdf

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
substrate 1737 inducer 781	substrate 1037 inhibitor 1767	substrate 1217 inhibitor 1852	inhibitor 1612

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
CYP3A 214 P-gp 1461 CYP1A2 1524 CYP2B6 810 CYP2C8 911 CYP2C19 1478 OATP1B1 788 OATP1B3 706 BCRP 699 Ca2+ channels 57 L-type Ca2+ channels 28 Nav1.5 97	CYP3A5 395 CYP2C19 991 CYP2C8 693 CYP1A2 1054 P-gp 1537	CYP3A 129 CYP1A2 701

Drug as perpetrator

Target	Modality	Activity	Clinical evidence
CYP1A2 1692	inducer 1573 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	no
CYP3A 298	inducer 1573 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	no
OATP1B3 715	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	weak [IC50 44 uM]
OATP1B1 803	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	weak [IC50 48 uM]
BCRP 773	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	weak [Inhibition 30 uM]
Ca2+ channels 60	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000PharmR.pdf	yes [IC50 0.83 uM]
L-type Ca2+ channels 30	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000PharmR.pdf	yes [IC50 14.6 uM]
CYP2B6 1001	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	yes [IC50 22 uM]
CYP2C9 1819	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	yes [IC50 23 uM]
P-gp 1650	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	yes [IC50 5.79 uM]
CYP3A 298	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	yes [IC50 7.3 uM]	yes (co-administration study) Comment: crizotinib increased AUC of midazolam by 3.7x Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf
CYP1A2 1692	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	yes [IC50 >30 uM]
CYP2C19 1553	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	yes [IC50 >30 uM]
CYP2C8 965	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	yes [IC50 >30 uM]
CYP2D6 1891	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	yes [IC50 >30 uM]
CYP3A4 1925	inducer 1573 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	yes	no (co-administration study) Comment: effect is masked by inhibition Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf

Drug as victim

Target	Modality	Activity	Clinical evidence
CYP3A4 1737	substrate 3367 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	major	yes (co-administration study) Comment: ketoconazole increased cmax of crizotinib by 44%, auc by 216% Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf
CYP3A5 395	substrate 3367 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	major	yes (co-administration study) Comment: ketoconazole increased cmax of crizotinib by 44%, auc by 216% Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf
CYP2C19 991	substrate 3367 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	minor
CYP2D6 1217	substrate 3367 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	minor
CYP1A2 1054	substrate 3367 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	no
CYP2C8 693	substrate 3367 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	no
CYP2C9 1037	substrate 3367 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	no
P-gp 1537	substrate 3367 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf	yes

Tox targets

Target	Modality	Activity	Metabolite	Clinical evidence
Nav1.5 100	inhibitor 1626 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000PharmR.pdf
hERG 1647	inhibitor 1626 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000PharmR.pdf

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:64310	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:64310
MolPort	MolPort-009-679-404	https://www.molport.com/shop/molecule-link/MolPort-009-679-404
Selleck Chemicals	PF-2341066	http://www.selleckchem.com/products/PF-2341066.html
ZINC	ZINC000035902489	http://zinc15.docking.org/substances/ZINC000035902489
eMolecules	31526065	https://www.emolecules.com/cgi-bin/more?vid=31526065

PubMed

Title	Date	PubMed
Parameters for individualizing systemic therapy in non-small cell lung cancer.	2010 Dec	21051275
Gender specific drug metabolism of PF-02341066 in rats--role of sulfoconjugation.	2010 May	20446906
Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry.	2010 Nov 24	21095574
Synthesis and c-Met kinase inhibition of 3,5-disubstituted and 3,5,7-trisubstituted quinolines: identification of 3-(4-acetylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7- (trifluoromethyl)quinoline as a novel anticancer agent.	2011 Apr 14	21405128
Favorable response to crizotinib in three patients with echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase fusion-type oncogene-positive non-small cell lung cancer.	2011 Aug	21767331
Differential (18)F-FDG and 3'-deoxy-3'-(18)F-fluorothymidine PET responses to pharmacologic inhibition of the c-MET receptor in preclinical tumor models.	2011 Aug	21764800
ALK mutations conferring differential resistance to structurally diverse ALK inhibitors.	2011 Dec 1	21948233
Genotype-driven therapies for non-small cell lung cancer: focus on EGFR, KRAS and ALK gene abnormalities.	2011 May	21904575
Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis.	2011 Oct	21933749
MET tyrosine kinase inhibitor crizotinib (PF-02341066) shows differential antitumor effects in non-small cell lung cancer according to MET alterations.	2011 Oct	21716144
Comprehensive analysis of kinase inhibitor selectivity.	2011 Oct 30	22037378
Echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase-targeted therapy for advanced non-small cell lung cancer: molecular and clinical aspects.	2012 Aug	22568572
Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification.	2012 Jul	22729845
Development of treatment strategies for advanced neuroblastoma.	2012 Jun	22588779
Pharmacokinetic/pharmacodynamic modeling of crizotinib for anaplastic lymphoma kinase inhibition and antitumor efficacy in human tumor xenograft mouse models.	2012 Mar	22129595
ROS1 rearrangements define a unique molecular class of lung cancers.	2012 Mar 10	22215748
Differential protein stability and ALK inhibitor sensitivity of EML4-ALK fusion variants.	2012 Sep 1	22912387
Prediction of crizotinib-midazolam interaction using the Simcyp population-based simulator: comparison of CYP3A time-dependent inhibition between human liver microsomes versus hepatocytes.	2013 Feb	23129213
Crizotinib for the treatment of non-small-cell lung cancer.	2013 Jun 1	23686600

Patents

Sample Use Guides

In Vivo Use Guide

The recommended dose and schedule for crizotinib is 250 mg orally, twice daily, with or without food.

Route of Administration: fVal

In Vitro Use Guide

PF-2341066 potently inhibited NPM-ALK phosphorylation in Karpas299 or SU-DHL-1 ALCL cells (mean IC50 value of 24 nmol/L). In biochemical and cellular screens, PF-2341066 was shown to be selective for c-Met and ALK at pharmacologically relevant concentrations across a panel of >120 diverse kinases. PF-2341066 potently inhibited cell proliferation, which was associated with G(1)-S-phase cell cycle arrest and induction of apoptosis in ALK-positive ALCL cells at IC50 values of approximately 30 nmol/L but not ALK-negative lymphoma cells.

Name

Type

Language

Crizotinib

Official Name

English

CRIZOTINIB [USAN]

Common Name

English

CRIZOTINIB [JAN]

Common Name

English

CRIZOTINIB [ORANGE BOOK]

Common Name

English

CRIZOTINIB [MI]

Common Name

English

3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine

Systematic Name

English

PF-02341066

Code

English

2-Pyridinamine, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-

Systematic Name

English

NSC-756645

Code

English

CRIZOTINIB [MART.]

Common Name

English

CRIZOTINIB [VANDF]

Common Name

English

1066

Code

English

PF-2341066

Common Name

English

Crizotinib [WHO-DD]

Common Name

English

XALKORI

Brand Name

English

crizotinib [INN]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QL01XE16