U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C10H14N5O8P
Molecular Weight 363.221
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FOSDENOPTERIN

SMILES

C1[C@]2([H])[C@@]([H])(C([C@@]3([H])[C@]([H])(Nc4c(c(nc(=N)[nH]4)O)N3)O2)(O)O)OP(=O)(O)O1

InChI

InChIKey=CZAKJJUNKNPTTO-AJFJRRQVSA-N
InChI=1S/C10H14N5O8P/c11-9-14-6-3(7(16)15-9)12-4-8(13-6)22-2-1-21-24(19,20)23-5(2)10(4,17)18/h2,4-5,8,12,17-18H,1H2,(H,19,20)(H4,11,13,14,15,16)/t2-,4-,5+,8-/m1/s1

HIDE SMILES / InChI
Cyclic pyranopterin monophosphate is a precursor to molybdenum cofactor, which is required for the enzyme activity of sulfite oxidase, xanthine dehydrogenase/oxidase, and aldehyde oxidase. The drug is being investigated in severe molybdenum cofactor deficiency type A. In a clinical study, intravenous administration of the drug resulted in greatly improved neurodevelopmental outcome when started sufficiently early.

Approval Year

Name Type Language
CYCLIC PYRANOPTERIN MONOPHOSPHATE
Preferred Name English
FOSDENOPTERIN
INN   USAN  
Official Name English
ALXN-1101 ANHYDROUS FREE BASE
Code English
PRECURSOR Z
Common Name English
C(PMP)
Common Name English
1,3,2-DIOXAPHOSPHORINO(4',5':5,6)PYRANO(3,2-G)PTERIDIN-10(4H)-ONE, 8-AMINO-4A,5A,6,7,11,11A,12,12A-OCTAHYDRO-2,12,12-TRIHYDROXY-, 2-OXIDE, (4AR,5AR,11AR,12AS)-
Common Name English
CPMP
Common Name English
FOSDENOPTERIN [INN]
Common Name English
FOSDENOPTERIN [USAN COUN]
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 291209
Created by admin on Sat Jun 26 08:52:27 UTC 2021 , Edited by admin on Sat Jun 26 08:52:27 UTC 2021
EU-Orphan Drug EU/3/10/777
Created by admin on Sat Jun 26 08:52:27 UTC 2021 , Edited by admin on Sat Jun 26 08:52:27 UTC 2021
Code System Code Type Description
CAS
150829-29-1
Created by admin on Sat Jun 26 08:52:27 UTC 2021 , Edited by admin on Sat Jun 26 08:52:27 UTC 2021
PRIMARY
EVMPD
SUB197148
Created by admin on Sat Jun 26 08:52:27 UTC 2021 , Edited by admin on Sat Jun 26 08:52:27 UTC 2021
PRIMARY
NCI_THESAURUS
C175065
Created by admin on Sat Jun 26 08:52:27 UTC 2021 , Edited by admin on Sat Jun 26 08:52:27 UTC 2021
PRIMARY
WIKIPEDIA
Cyclic pyranopterin monophosphate
Created by admin on Sat Jun 26 08:52:27 UTC 2021 , Edited by admin on Sat Jun 26 08:52:27 UTC 2021
PRIMARY
FDA UNII
4X7K2681Y7
Created by admin on Sat Jun 26 08:52:27 UTC 2021 , Edited by admin on Sat Jun 26 08:52:27 UTC 2021
PRIMARY
INN
11150
Created by admin on Sat Jun 26 08:52:27 UTC 2021 , Edited by admin on Sat Jun 26 08:52:27 UTC 2021
PRIMARY
PUBCHEM
135463437
Created by admin on Sat Jun 26 08:52:27 UTC 2021 , Edited by admin on Sat Jun 26 08:52:27 UTC 2021
PRIMARY