Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C34H33N4O6.3Na |
| Molecular Weight | 662.6183 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[Na+].[Na+].CCC1=C(C)C2=NC1=CC3=C(C)C(C([O-])=O)=C(N3)C(CC([O-])=O)=C4N=C(C=C5NC(=C2)C(C=C)=C5C)[C@@H](C)[C@@H]4CCC([O-])=O
InChI
InChIKey=GVBNHHULZRENLV-BTFXJMARSA-K
InChI=1S/C34H36N4O6.3Na/c1-7-19-15(3)23-12-25-17(5)21(9-10-29(39)40)32(37-25)22(11-30(41)42)33-31(34(43)44)18(6)26(38-33)14-28-20(8-2)16(4)24(36-28)13-27(19)35-23;;;/h7,12-14,17,21,35,38H,1,8-11H2,2-6H3,(H,39,40)(H,41,42)(H,43,44);;;/q;3*+1/p-3/b23-12-,24-13-,25-12-,26-14-,27-13-,28-14-,32-22-,33-22-;;;/t17-,21-;;;/m0.../s1
Chlorophyllin is a water soluble derivative of chlorophyll. It has chemopreventive properties and forms a non-covalent complex with many mutagenic/carcinogenic molecules. Chlorophyllin inhibits cancer initiation and progression by targeting multiple molecules and pathways involved in the metabolism of carcinogens, cell cycle progression, apoptosis evasion, invasion, and angiogenesis. The modulatory effects of Chlorophyllin to be mediated via abrogation of key oncogenic signal transduction pathways such as nuclear factor kappa B, Wnt/β-catenin, and phosphatidylinositol-3-kinase/Akt signaling. Chlorophyllin sodium copper salt mitigates radiation-induced hematopoietic syndrome by increasing the abundance of hematopoietic stem cells, enhancing granulopoiesis, and stimulating prosurvival pathways in bone marrow cells and lymphocytes. In addition, chlorophyllin exhibits antioxidant, antiapoptotic and immunostimulatory effects. Chlorophyllin is intended to improve the quality of life in people who have fecal incontinence due to spinal cord injury, bowel cancer, psychotic disorder, terminal illness, or other disorders. Chlorophyllin is also used by people who have had a colostomy or ileostomy
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: GO:0030097 |
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Target ID: GO:0070527 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Palliative | Unknown Approved UseUnknown |
|||
| Primary | Unknown Approved UseUnknown |
|||
| Palliative | Derifil Approved UseDerifil has been used in alternative medicine as an aid to reduce the odor of urine or feces (bowel movements).
Derifil is intended to improve the quality of life in people who have fecal incontinence due to spinal cord injury, bowel cancer, psychotic disorder, terminal illness, or other disorders. This medicine is also used by people who have had a colostomy or ileostomy. |
PubMed
| Title | Date | PubMed |
|---|---|---|
| G-Quadruplex-Based Nanoscale Coordination Polymers to Modulate Tumor Hypoxia and Achieve Nuclear-Targeted Drug Delivery for Enhanced Photodynamic Therapy. | 2018-11-14 |
|
| Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses. | 2017-10-12 |
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| Pathological and biochemical evaluation of coumarin and chlorophyllin against aflatoxicosis in rat. | 2017-06-14 |
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| Carrier-Free, Chemophotodynamic Dual Nanodrugs via Self-Assembly for Synergistic Antitumor Therapy. | 2016-06-01 |
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| Amelioration of radiation-induced hematopoietic syndrome by an antioxidant chlorophyllin through increased stem cell activity and modulation of hematopoiesis. | 2015-08 |
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| Interaction of porphyrins with human organic anion transporting polypeptide 1B1. | 2009-11-10 |
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| [Targeting of chlorine E6 by EGF increasing its photodynamic activity in selective ways]. | 2000 |
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| A screening assay for antiviral compounds targeted to the HIV-1 gp41 core structure using a conformation-specific monoclonal antibody. | 1999-06 |
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| Three-dimensional structure-activity analysis of a series of porphyrin derivatives with anti-HIV-1 activity targeted to the V3 loop of the gp120 envelope glycoprotein of the human immunodeficiency virus type 1. | 1994-04-15 |
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| Effect of chlorophyllin on urinary odor in incontinent geriatric patients. | 1983-10 |
Sample Use Guides
urinary odor: each patient received chlorophyllin 100 mg/d for two weeks and placebo daily for two weeks, separated by a washout period of one week.
Route of Administration:
Oral
It was investigated the effects on cell proliferation and the expression of genes involved in apoptosis, and the cell cycle in HB4a cells treated with Chlorophyllin (Chl). Chl was cytotoxic and induced apoptosis to HB4a cells at 400 μg/mL. Analysis of gene expression showed that there was a decrease in the mRNA level of BIRC5 and CCNA2 genes involved in apoptosis and cell cycle progression, respectively. The proapoptotic gene BAX and the antiapoptotic genes BCL-2 and BCL-XL were upregulated. The cytotoxicity of Chl has been attributed to increases in the expression of BAX and decreases in the expression of genes involved in the cell cycle, but increases in the expression of anti-apoptotic genes suggests a mechanism for protection from cell death induced by Chl.
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72984-36-2
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462U222HKD
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DTXSID301340638
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277-169-4
Created by
admin on Wed Apr 02 06:23:58 GMT 2025 , Edited by admin on Wed Apr 02 06:23:58 GMT 2025
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ACTIVE MOIETY
SUBSTANCE RECORD
