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Description
Curator's Comment: description was created based on several sources, including: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5176be07-3121-49fb-9eb9-638903753a31 | https://www.drugs.com/monograph/atracurium-besylate.html | http://www.wikidoc.org/index.php/Atracurium

Atracurium is an intermediate-duration, nondepolarizing, skeletal muscle relaxant for intravenous administration. It is used, as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Most adverse reactions were suggestive of histamine release. Common side effects include flushing of the skin and low blood pressure. Drugs which may enhance the neuromuscular blocking action of atracurium include: enflurane; isoflurane; halothane; certain antibiotics, especially the aminoglycosides and polymyxins; lithium; magnesium salts; procainamide; and quinidine.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
169.5 nM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
ATRACURIUM BESYLATE

Approved Use

Atracurium Besylate Injection, USP is indicated, as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Launch Date

1997
PubMed

PubMed

TitleDatePubMed
Donepezil in Alzheimer's disease: From conventional trials to pharmacogenetics.
2007 Jun
Anaesthetic management of post-burn contractures, a recurrent challenge from oil pipeline vandalization in Nigeria: a case report.
2009 Dec 3
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.
2010 Dec
Comparison between Culture Conditions Improving Growth and Differentiation of Blood and Bone Marrow Cells Committed to the Endothelial Cell Lineage.
2010 Feb 6
Patents

Sample Use Guides

An atracurium besylate dose of 0.4 to 0.5 mg/kg (1.7 to 2.2 times the ED95), given as an intravenous bolus injection, is the recommended initial dose for most patients. Maximum neuromuscular block achieved approximately 3 to 5 minutes after injection.
Route of Administration: Intravenous
In Vitro Use Guide
Exposure of isolated rat hepatocytes to atracurium produced cellular damage evidenced by extrusion of an intracellular enzyme, lactate dehydrogenase (LDH), into the incubation medium. Leakage of LDH was directly related to the concentration of atracurium in the medium (250 to 800 microM). When atracurium was added to the medium and the medium immediately added to hepatocytes, the leakage of LDH increased as the concentration of atracurium increased (P < 0.001 for the comparison with cells not exposed to atracurium).
Name Type Language
ATRACURIUM
VANDF   WHO-DD  
Common Name English
ATRACURIUM CATION
Common Name English
ATRACURIUM [VANDF]
Common Name English
2-(2-CARBOXYETHYL)-1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-2-METHYL-1-VERATRYLISOQUINOLINIUM, PENTAMETHYLENE ESTER
Common Name English
ISOQUINOLINIUM, 2,2'-(1,5-PENTANEDIYLBIS(OXY(3-OXO-3,1-PROPANEDIYL)))BIS(1-((3,4-DIMETHOXYPHENYL)METHYL)-1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-2-METHYL
Common Name English
ATRACURIUM ION
Common Name English
Atracurium [WHO-DD]
Common Name English
Classification Tree Code System Code
NDF-RT N0000175720
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WHO-ESSENTIAL MEDICINES LIST 20
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WHO-VATC QM03AC04
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NCI_THESAURUS C66886
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WHO-ATC M03AC04
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NDF-RT N0000175732
Created by admin on Fri Dec 15 16:22:30 GMT 2023 , Edited by admin on Fri Dec 15 16:22:30 GMT 2023
Code System Code Type Description
FDA UNII
2GQ1IRY63P
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MESH
D001279
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CHEBI
2914
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NCI_THESAURUS
C76068
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LACTMED
Atracurium
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EVMPD
SUB00618MIG
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EPA CompTox
DTXSID9043726
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CAS
64228-79-1
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DRUG CENTRAL
259
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DAILYMED
2GQ1IRY63P
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DRUG BANK
DB00732
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RXCUI
1218
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PRIMARY RxNorm
WIKIPEDIA
ATRACURIUM
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Definition References