DISODIUM URATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C5H2N4O3.2Na
Molecular Weight	212.0739
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[Na+].O=C1NC2=C(NC(=O)[N-]C2=O)[N-]1

InChI

InChIKey=JNNYOCABZPYQDB-UHFFFAOYSA-L

InChI=1S/C5H4N4O3.2Na/c10-3-1-2(7-4(11)6-1)8-5(12)9-3;;/h(H4,6,7,8,9,10,11,12);;/q;2*+1/p-2

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25422986
Curator's Comment: description was created based on several sources, including: https://www.drugs.com/dict/uric-acid.html | http://www.wikidoc.org/index.php/Uric_acid

Uric acid, generated from the metabolism of purines, has proven and emerging roles in human disease. Humans produce large quantities of uric acid. Excess serum accumulation of uric acid can lead to a type of arthritis known as gout. Hyperuricemia may increase risk factors for cardiovascular disease. High serum uric acid was associated with higher risk of type 2 diabetes and other diseases.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Urate oxidase (mammals) 3 Target ID: Urate oxidase (mammals) Sources: https://www.ncbi.nlm.nih.gov/pubmed/2594778	Substrate 661

Conditions

Condition	Modality	Highest Phase	Product
Multiple sclerosis 104 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23528410 https://www.ncbi.nlm.nih.gov/pubmed/11985629	Diagnostic	Natural Metabolite	Unknown Approved Use Unknown
Type 2 diabetes mellitus 259 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17977935	Diagnostic	Natural Metabolite	Unknown Approved Use Unknown
Cardiovascular diseases 71 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25192804	Diagnostic	Natural Metabolite	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Prostaglandin inhibition by intraperitoneal indomethacin has no effect on peritoneal permeability during stable CAPD.	2001 Apr	11274278
The potential role of adenosine in the pathophysiology of the insulin resistance syndrome.	2001 Apr	11254897
Laryngeal manifestation of gout: a case report of a subglottic gout tophus.	2001 Aug	11489374
Uric acid or urate nephropathy?	2001 Aug	11479177
Experimental meningitis in the rat: protection by uric acid at human physiological blood concentrations.	2001 Aug 10	11502281
Photosensitizer initiated attacks on DNA under dry conditions and their inhibition: a DNA archiving issue.	2001 Aug 15	11485843
Water-soluble antioxidants in human tears: effect of the collection method.	2001 Dec	11726613
Role of exercise and ascorbate on plasma antioxidant capacity in thoroughbred race horses.	2001 Jan	11137442
The role of uric acid in protection against peroxynitrite-mediated pathology.	2001 Jan	11133262
Pathways for urea production during early life of an air-breathing teleost, the African catfish Clarias gariepinus Burchell.	2001 Jun	11441057
Urate and arteriosclerosis in primary hyperparathyroidism.	2001 Jun	11422116
Evidence for alterations in circulating low-molecular-weight antioxidants and increased lipid peroxidation in smokers on hemodialysis.	2001 Jun	11399914
Renal regulation of plasma total antioxidant capacity.	2001 Jun	11399110
Cystine calculi in children: the results of a metabolic evaluation and response to medical therapy.	2001 Jun	11371943
Contribution of peroxynitrite to the beneficial effects of preconditioning on ischaemia-induced arrhythmias in rat isolated hearts.	2001 Mar	11275005
Binding of urate and caffeine to haemocyanin analysed by isothermal titration calorimetry.	2001 Mar	11171426
Uric acid and cardiovascular disease: a renal-cardiac relationship?	2001 May	11342800
Functional reconstitution, membrane targeting, genomic structure, and chromosomal localization of a human urate transporter.	2001 May	11342574
A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis.	2001 May 15	11342423
Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism.	2001 Nov	11711505
Isolation and characterization of the DLAD/Dlad genes, which lie head-to-head with the genes for urate oxidase.	2001 Nov 16	11700027
Ozone causes lipid peroxidation but little antioxidant depletion in exercising and nonexercising hamsters.	2001 Oct	11568152
A family-based study of metabolic phenotypes in calcium urolithiasis.	2001 Sep	11532110
Xanthine oxidase-derived reactive oxygen species convert flow-induced arteriolar dilation to constriction in hyperhomocysteinemia: possible role of peroxynitrite.	2002 Jan	11788457
Electrosynthesis of poly-o-diaminobenzene on the Prussian Blue modified electrodes for improvement of hydrogen peroxide transducer characteristics.	2002 Jan	11786361

Patents

Sample Use Guides

In Vivo Use Guide

Mice: twice daily with 10 mg per dose for 7 days

Route of Administration: Intraperitoneal

In Vitro Use Guide

Uric acid (5 mg/dL) significantly increased MCP-1 production by rat vascular smooth muscle cells at 3, 6, and 24 hours when compared with that of control media.

Name

Type

Language

DISODIUM URATE

Common Name

English

1H-PURINE-2,6,8(3H)-TRIONE, 7,9-DIHYDRO-, SODIUM SALT (1:2)

Systematic Name

English

URIC ACID, DISODIUM SALT

Common Name

English

Code System Code Type Description

CAS

134-69-0