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Details

Stereochemistry RACEMIC
Molecular Formula C4H5N4O3.2Al.Cl.4HO
Molecular Weight 314.553
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ALCLOXA

SMILES

[OH-].[OH-].[OH-].[OH-].[Al+3].[Al+3].[Cl-].NC(=O)NC1NC(=O)[N-]C1=O

InChI

InChIKey=IMZDRXBSGZPLDE-UHFFFAOYSA-H
InChI=1S/C4H6N4O3.2Al.ClH.4H2O/c5-3(10)6-1-2(9)8-4(11)7-1;;;;;;;/h1H,(H5,5,6,7,8,9,10,11);;;1H;4*1H2/q;2*+3;;;;;/p-6

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including: http://tri-k.com/acloxa

Aldioxa is the generic name for the metal complex, dihydroxyaluminum allantoinate, which is hydrolyzed to allantoin and aluminium hydrate at the gastric mucosa. Aldioxa was approved in Japan to improve subjective symptoms or objective of gastric/duodenal ulcer and gastritis. It was discovered, that aldioxa ameliorates delayed gastric emptying through its antagonistic activity on the α-2 adrenergic receptor. The most commonly reported adverse reactions include constipation.

Approval Year

1961
146
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2778
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Not Provided
504
BODYGLIDE FOR HER

Approved Use

helps prevent and helps relieve chafed, chapped or cracked skin. helps protect from the drying effects of wind and cold weather. temporarily protects minor cuts, scrapes, burns.

Launch Date

2009
Primary
Preclinical
Unknown

Approved Use

Unknown
Primary
Approved
8429
Unknown

Approved Use

protects gastric / duodenal tissue mucosa and helps repair, thus improving gastric / duodenal ulcer and gastritis. It is usually used to improve subjective symptoms or objective of gastric/duodenal ulcer and gastritis.
Primary
Approved
8429
Unknown

Approved Use

protects gastric / duodenal tissue mucosa and helps repair, thus improving gastric / duodenal ulcer and gastritis. It is usually used to improve subjective symptoms or objective of gastric/duodenal ulcer and gastritis.
Primary
Approved
8429
Unknown

Approved Use

protects gastric / duodenal tissue mucosa and helps repair, thus improving gastric / duodenal ulcer and gastritis. It is usually used to improve subjective symptoms or objective of gastric/duodenal ulcer and gastritis.
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
6.43 μg/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/9131540/
10 mg/kg 3 times / day steady-state, oral
dose: 10 mg/kg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
ALLANTOIN plasma
Canis lupus
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
30 μg × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/9131540/
10 mg/kg 3 times / day steady-state, oral
dose: 10 mg/kg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
ALLANTOIN plasma
Canis lupus
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
2.69 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/9131540/
10 mg/kg 3 times / day steady-state, oral
dose: 10 mg/kg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
ALLANTOIN plasma
Canis lupus
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Sourcing

Sourcing

Vendor/AggregatorIDURL
ChEBI
CHEBI:15676
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:15676
ChemicalBook
CB3215461
https://www.chemicalbook.com/ChemicalProductProperty_EN_CB3215461
MolPort
MolPort-001-779-876
https://www.molport.com/shop/molecule-link/MolPort-001-779-876
eMolecules
476195
https://www.emolecules.com/cgi-bin/more?vid=476195
PubMed

PubMed

TitleDatePubMed
[Evaluation of the anti-ulcer drugs using image analysis technology: effect of aldioxa containing preparation on the experimental gastric ulcer in rats].
1989 Nov
Aldioxa improves delayed gastric emptying and impaired gastric compliance, pathophysiologic mechanisms of functional dyspepsia.
2015 Dec 1

Sample Use Guides

In Vivo Use Guide
Sources: file:///C:/Users/Mark/Desktop/info_20ALCLOXA.pdf
Antiperspirants, deodorants: Creams, spray, lossions: 0.25-0.5% Baby products: creams; powders: 0.2-0.5%
Route of Administration: Topical
In Vitro Use Guide
Sources: file:///C:/Users/Mark/Desktop/info_20ALCLOXA.pdf
In vitro Alcloxa inhibited formation and bacterial decomposition of pulverized human epidermal scales. The scales were obtained from patient with exfoliative dermatitis, characterized by a great deal of exudation. The scales were were pulverized in a Wiley mill, defatted with ether and suspended in a 0,2% Alcloxa solution.
Name Type Language
ALCLOXA
INCI   INN   JAN   MART.   USAN   VANDF   WHO-DD  
INCI   INN   USAN  
Official Name English
ALUMINIUM, CHLOROTETRAHYDROXY((4,5-DIHYDRO-2-HYDROXY-5-OXO-1H-IMIDAZOL-4-YL)UREATO)DI-
Common Name English
CHLOROTETRAHYDROXY((2-HYDROXY-5-OXO-2-IMIDAZOLIN-4-YL)UREATO)DIALUMINIUM
Common Name English
ALCLOXA [INCI]
Common Name English
Chlorotetrahydroxy[(2-hydroxy-5-oxo-2-imidazolin-4-yl)ureato]dialuminum
Common Name English
ALLANTOLOX
Brand Name English
RC-173
Code English
ALUMINIUM CHLORHYDROXY ALLANTOINATE
Common Name English
ALCLOXA [JAN]
Common Name English
ALCLOXA [MART.]
Common Name English
ALCLOXA [USAN]
Common Name English
ALUMINUM CHLORHYDROXY ALLANTOINATE
II  
Common Name English
Alcloxa [WHO-DD]
Common Name English
ALUMINUM CHLOROHYDROXY ALLANTOINATE
Common Name English
alcloxa [INN]
Common Name English
ALUMINUM CHLORHYDROXY ALLANTOINATE [II]
Common Name English
ALCLOXA [VANDF]
Common Name English
ALUMINUM, CHLOROTETRAHYDROXY((4,5-DIHYDRO-2-HYDROXY-5-OXO-1H-IMIDAZOL-4-YL)UREATO)DI-
Common Name English
ALUMINIUM CHLOROHYDROXY ALLANTOINATE
Common Name English
ALCA
Code English
Classification Tree Code System Code
CFR 21 CFR 346.20
Created by admin on Fri Dec 15 19:07:01 GMT 2023 , Edited by admin on Fri Dec 15 19:07:01 GMT 2023
NCI_THESAURUS C29700
Created by admin on Fri Dec 15 19:07:02 GMT 2023 , Edited by admin on Fri Dec 15 19:07:02 GMT 2023
EPA PESTICIDE CODE 85703
Created by admin on Fri Dec 15 19:07:01 GMT 2023 , Edited by admin on Fri Dec 15 19:07:01 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C76518
Created by admin on Fri Dec 15 19:07:02 GMT 2023 , Edited by admin on Fri Dec 15 19:07:02 GMT 2023
PRIMARY
RXCUI
1305554
Created by admin on Fri Dec 15 19:07:02 GMT 2023 , Edited by admin on Fri Dec 15 19:07:02 GMT 2023
PRIMARY RxNorm
CAS
1317-25-5
Created by admin on Fri Dec 15 19:07:01 GMT 2023 , Edited by admin on Fri Dec 15 19:07:01 GMT 2023
PRIMARY
ECHA (EC/EINECS)
215-262-3
Created by admin on Fri Dec 15 19:07:01 GMT 2023 , Edited by admin on Fri Dec 15 19:07:01 GMT 2023
PRIMARY
FDA UNII
18B8O9DQA2
Created by admin on Fri Dec 15 19:07:01 GMT 2023 , Edited by admin on Fri Dec 15 19:07:01 GMT 2023
PRIMARY
SMS_ID
100000087735
Created by admin on Fri Dec 15 19:07:02 GMT 2023 , Edited by admin on Fri Dec 15 19:07:02 GMT 2023
PRIMARY
DRUG BANK
DB11205
Created by admin on Fri Dec 15 19:07:01 GMT 2023 , Edited by admin on Fri Dec 15 19:07:01 GMT 2023
PRIMARY
EVMPD
SUB05301MIG
Created by admin on Fri Dec 15 19:07:01 GMT 2023 , Edited by admin on Fri Dec 15 19:07:01 GMT 2023
PRIMARY
DAILYMED
18B8O9DQA2
Created by admin on Fri Dec 15 19:07:01 GMT 2023 , Edited by admin on Fri Dec 15 19:07:01 GMT 2023
PRIMARY
INN
1633
Created by admin on Fri Dec 15 19:07:01 GMT 2023 , Edited by admin on Fri Dec 15 19:07:01 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of ALUMINUM CATION
ACTIVE MOIETY
Structure of Allantoin
ACTIVE MOIETY
Structure of ALCLOXA
NIH
NCATS
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