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Details

Stereochemistry ACHIRAL
Molecular Formula Al
Molecular Weight 26.9815
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 3

SHOW SMILES / InChI
Structure of ALUMINUM CATION

SMILES

[Al+3]

InChI

InChIKey=REDXJYDRNCIFBQ-UHFFFAOYSA-N
InChI=1S/Al/q+3

HIDE SMILES / InChI

Molecular Formula Al
Molecular Weight 26.9815
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including https://www.google.com/patents/US2824042 | https://www.ncbi.nlm.nih.gov/pubmed/22718290 | https://www.ncbi.nlm.nih.gov/pubmed/15516810 | https://www.ncbi.nlm.nih.gov/pubmed/10211213 | https://www.drugs.com/monograph/aluminum-acetate.html

Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations. At present the oflicial U. S. P. procedure to made Burow's solution involves the reaction of aluminum sulfate, calcium carbonate and acetic acid to form aluminum sub-acetate, also termed basic aluminum acetate. The solution is available as an over-the-counter drug for topical administration, with brand names including Domeboro. Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. It is active against bacteria resulting in damage to the cell wall.

Originator

Curator's Comment: Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
DOMEBORO

Approved Use

Temporarily relieves minor skin irritations due to: – Poison ivy | – Poison oak – Poison sumac | – Insect bites – Athlete’s foot | – Rashes caused by soaps, detergents, cosmetics, or jewelry
Curative
DOMEBORO

Approved Use

This medication is used to treat an outer ear infection (external otitis). This product contains acetic acid/aluminum acetate, a combination that stops the growth of bacteria and fungus. Treating the infection reduces pain and swelling in the ear. Wetness in the ear canal can help bacteria and fungus to grow. This medication also causes drying of the ear canal, helping to cure the infection.
PubMed

PubMed

TitleDatePubMed
Requirement for intramolecular domain interaction in activation of G protein alpha subunit by aluminum fluoride and GDP but not by GTP gamma S.
1994 Nov 25
Cholinesterase inhibition by aluminium phosphide poisoning in rats and effects of atropine and pralidoxime chloride.
2001 Jan
Fluoride plus aluminum: useful tools in laboratory investigations, but messengers of false information.
2002
Aluminum as a toxicant.
2002 Aug
[Pharmaceutical and pharmacological evaluation of Burow's solution (aluminum acetate solution), hospital preparation, and development of its rapid preparation method].
2004 Nov
Effects of aluminum on the nervous system and its possible link with neurodegenerative diseases.
2005 Nov
Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients.
2006
Mechanisms of aluminum-induced neurodegeneration in animals: Implications for Alzheimer's disease.
2006 Nov
1H NMR spectroscopic analysis detects metabolic disturbances in rat urine on acute exposure to heavy metal tungsten alloy based metals salt.
2014 Mar 25
Patents

Sample Use Guides

DOMEBORO® SOOTHING SOAK – dissolve 1 to 3 packets in a pint (16 oz) of cool or warm water – stir until fully dissolved; do not strain or filter. The resulting mixture contains 0.16% (1 packet), 0.32% (2 packets), or 0.48% (3 packets) aluminum acetate and is ready for use For use as a soak: – soak affected area for 15 to 30 minutes as needed, or as directed by a doctor – repeat 3 times a day or as directed by a doctor – discard solution after each use. For use as a compress or wet dressing: – soak a clean, soft cloth in the solution. – apply cloth loosely to affected area for 15 to 30 minutes – repeat as needed or as directed by a doctor – discard solution after each use
Route of Administration: Topical
Burow's solution (13% aluminum subacetate) is active against S. aureus and P. aeruginosa, resulting in damage to the cell wall.
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:06:13 UTC 2023
Edited
by admin
on Fri Dec 15 16:06:13 UTC 2023
Record UNII
3XHB1D032B
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ALUMINUM CATION
Common Name English
ALUMINIUM, ION (AL3+)
Common Name English
ALUMINUM ION
Common Name English
ALUMUNUM ION
Common Name English
ALUMINUM(III)
Systematic Name English
AL3+
Common Name English
ALUMINUM(III) ION
Common Name English
ALUMINUM(3+)
Systematic Name English
ALUMINIUM CATION
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C68232
Created by admin on Fri Dec 15 16:06:14 UTC 2023 , Edited by admin on Fri Dec 15 16:06:14 UTC 2023
NCI_THESAURUS C597
Created by admin on Fri Dec 15 16:06:14 UTC 2023 , Edited by admin on Fri Dec 15 16:06:14 UTC 2023
Code System Code Type Description
NCI_THESAURUS
C68233
Created by admin on Fri Dec 15 16:06:14 UTC 2023 , Edited by admin on Fri Dec 15 16:06:14 UTC 2023
PRIMARY
PUBCHEM
104727
Created by admin on Fri Dec 15 16:06:14 UTC 2023 , Edited by admin on Fri Dec 15 16:06:14 UTC 2023
PRIMARY
RXCUI
1546162
Created by admin on Fri Dec 15 16:06:14 UTC 2023 , Edited by admin on Fri Dec 15 16:06:14 UTC 2023
PRIMARY RxNorm
EPA CompTox
DTXSID70912343
Created by admin on Fri Dec 15 16:06:14 UTC 2023 , Edited by admin on Fri Dec 15 16:06:14 UTC 2023
PRIMARY
DRUG BANK
DB14519
Created by admin on Fri Dec 15 16:06:14 UTC 2023 , Edited by admin on Fri Dec 15 16:06:14 UTC 2023
PRIMARY
FDA UNII
3XHB1D032B
Created by admin on Fri Dec 15 16:06:14 UTC 2023 , Edited by admin on Fri Dec 15 16:06:14 UTC 2023
PRIMARY
CHEBI
60272
Created by admin on Fri Dec 15 16:06:14 UTC 2023 , Edited by admin on Fri Dec 15 16:06:14 UTC 2023
PRIMARY
CHEBI
30150
Created by admin on Fri Dec 15 16:06:14 UTC 2023 , Edited by admin on Fri Dec 15 16:06:14 UTC 2023
PRIMARY
DAILYMED
3XHB1D032B
Created by admin on Fri Dec 15 16:06:14 UTC 2023 , Edited by admin on Fri Dec 15 16:06:14 UTC 2023
PRIMARY
CHEBI
49470
Created by admin on Fri Dec 15 16:06:14 UTC 2023 , Edited by admin on Fri Dec 15 16:06:14 UTC 2023
PRIMARY
CAS
22537-23-1
Created by admin on Fri Dec 15 16:06:14 UTC 2023 , Edited by admin on Fri Dec 15 16:06:14 UTC 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY