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Details

Stereochemistry ACHIRAL
Molecular Formula Al
Molecular Weight 26.9815
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 3

SHOW SMILES / InChI
Structure of ALUMINUM CATION

SMILES

[Al+3]

InChI

InChIKey=REDXJYDRNCIFBQ-UHFFFAOYSA-N
InChI=1S/Al/q+3

HIDE SMILES / InChI

Molecular Formula Al
Molecular Weight 26.9815
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment:: Description was created based on several sources, including https://www.google.com/patents/US2824042 | https://www.ncbi.nlm.nih.gov/pubmed/22718290 | https://www.ncbi.nlm.nih.gov/pubmed/15516810 | https://www.ncbi.nlm.nih.gov/pubmed/10211213 | https://www.drugs.com/monograph/aluminum-acetate.html

Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations. At present the oflicial U. S. P. procedure to made Burow's solution involves the reaction of aluminum sulfate, calcium carbonate and acetic acid to form aluminum sub-acetate, also termed basic aluminum acetate. The solution is available as an over-the-counter drug for topical administration, with brand names including Domeboro. Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. It is active against bacteria resulting in damage to the cell wall.

Originator

Curator's Comment:: Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
DOMEBORO

Approved Use

Temporarily relieves minor skin irritations due to: – Poison ivy | – Poison oak – Poison sumac | – Insect bites – Athlete’s foot | – Rashes caused by soaps, detergents, cosmetics, or jewelry
Curative
DOMEBORO

Approved Use

This medication is used to treat an outer ear infection (external otitis). This product contains acetic acid/aluminum acetate, a combination that stops the growth of bacteria and fungus. Treating the infection reduces pain and swelling in the ear. Wetness in the ear canal can help bacteria and fungus to grow. This medication also causes drying of the ear canal, helping to cure the infection.
PubMed

PubMed

TitleDatePubMed
The ineffectiveness of aluminum subacetate in rheumatoid arthritis.
1948 Apr 8
Cardiovascular manifestations of aluminium phosphide intoxication.
1989 Sep
The antibacterial activity of acetic acid and Burow's solution as topical otological preparations.
1998 Oct
Effect of aluminum phosphide on blood glucose level.
1999 Feb
[TNF-alpha secretion by human macrophage-like cells in response to wear particles and its modification by drugs].
1999 May
Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study.
1999 May
Quartz exposure of the rat lung leads to a linear dose response in inflammation but not in oxidative DNA damage and mutagenicity.
2001 Apr
Fluoride plus aluminum: useful tools in laboratory investigations, but messengers of false information.
2002
Aluminum as a toxicant.
2002 Aug
Effects of polyethylene and alpha-alumina particles on IL-6 expression and secretion in primary cultures of human osteoblastic cells.
2002 Feb
Mechanisms of magnesium-stimulated adhesion of osteoblastic cells to commonly used orthopaedic implants.
2002 Nov
Final report on the safety assessment of aluminum silicate, calcium silicate, magnesium aluminum silicate, magnesium silicate, magnesium trisilicate, sodium magnesium silicate, zirconium silicate, attapulgite, bentonite, Fuller's earth, hectorite, kaolin, lithium magnesium silicate, lithium magnesium sodium silicate, montmorillonite, pyrophyllite, and zeolite.
2003
Aluminum inclusion macrophagic myofasciitis: a recently identified condition.
2003 Nov
The role of metals in neurodegenerative processes: aluminum, manganese, and zinc.
2003 Nov 15
Parenteral nutrition-associated cholestasis in neonates: the role of aluminum.
2003 Sep
Intracellular mechanisms underlying aluminum-induced apoptosis in rabbit brain.
2003 Sep 15
The influence of alumina and ultra-high molecular weight polyethylene particles on osteoblast-osteoclast cooperation.
2004 Aug
Matrix metalloproteinases MMP-2, -9 and tissue inhibitors TIMP-1, -2 expression and secretion by primary human osteoblast cells in response to titanium, zirconia, and alumina ceramics.
2004 Jan 1
Comparison of the response of primary human blood monocytes and the U937 human monocytic cell line to two different sizes of alumina ceramic particles.
2004 Jul
[Pharmaceutical and pharmacological evaluation of Burow's solution (aluminum acetate solution), hospital preparation, and development of its rapid preparation method].
2004 Nov
Aluminum: new recognition of an old problem.
2005 Dec
Molecular basis of osteoclastogenesis induced by osteoblasts exposed to wear particles.
2005 May
Effects of aluminum on the nervous system and its possible link with neurodegenerative diseases.
2005 Nov
Aluminum and Alzheimer's disease, a personal perspective after 25 years.
2006
Some aspects of astroglial functions and aluminum implications for neurodegeneration.
2006 Aug 30
Microdermabrasion with and without aluminum oxide crystal abrasion: a comparative molecular analysis of dermal remodeling.
2006 Mar
Aluminum and other metals in Alzheimer's disease: a review of potential therapy with chelating agents.
2006 Nov
Blood-brain barrier flux of aluminum, manganese, iron and other metals suspected to contribute to metal-induced neurodegeneration.
2006 Nov
Aluminum and Alzheimer's disease: a new look.
2006 Nov
The role of aluminum and copper on neuroinflammation and Alzheimer's disease.
2006 Nov
Mechanisms of aluminum-induced neurodegeneration in animals: Implications for Alzheimer's disease.
2006 Nov
Ototoxic effect of Burow solution applied to the guinea pig middle ear.
2007 Aug
Neurological adverse events of immunization: experience with an aluminum adjuvanted meningococcal B outer membrane vesicle vaccine.
2007 Oct
Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation.
2007 Oct
Ablative laser resurfacing: high-energy pulsed carbon dioxide and erbium:yttrium-aluminum-garnet.
2007 Sep-Oct
Human macrophage response to UHMWPE, TiAlV, CoCr, and alumina particles: analysis of multiple cytokines using protein arrays.
2008 Feb
Alumina nanoparticles induce expression of endothelial cell adhesion molecules.
2008 May 30
Efficacy of simple short-term in vitro assays for predicting the potential of metal oxide nanoparticles to cause pulmonary inflammation.
2009 Feb
The effects of implant surface nanoscale features on osteoblast-specific gene expression.
2009 Sep
Inhibition of a protein tyrosine phosphatase using mesoporous oxides.
2010 Mar 11
Aluminum nanoparticle exposure in L1 larvae results in more severe lethality toxicity than in L4 larvae or young adults by strengthening the formation of stress response and intestinal lipofuscin accumulation in nematodes.
2011 Jan
In vivo toxicity of nano-alumina on mice neurobehavioral profiles and the potential mechanisms.
2011 Jan-Mar
Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles.
2012 Apr
Al₂O₃ nanoparticles induce mitochondria-mediated cell death and upregulate the expression of signaling genes in human mesenchymal stem cells.
2012 Nov
Gene expression profile of mouse fibroblasts exposed to a biodegradable iron alloy for stents.
2013 Nov
Atomic layer deposition coating of carbon nanotubes with aluminum oxide alters pro-fibrogenic cytokine expression by human mononuclear phagocytes in vitro and reduces lung fibrosis in mice in vivo.
2014
1H NMR spectroscopic analysis detects metabolic disturbances in rat urine on acute exposure to heavy metal tungsten alloy based metals salt.
2014 Mar 25
Pesticide exposure and depression among male private pesticide applicators in the agricultural health study.
2014 Sep
Molecular basis of carcinogenicity of tungsten alloy particles.
2015 Mar 15
Toxicoproteomic analysis of pulmonary carbon nanotube exposure using LC-MS/MS.
2015 Mar 2
Patents

Sample Use Guides

DOMEBORO® SOOTHING SOAK – dissolve 1 to 3 packets in a pint (16 oz) of cool or warm water – stir until fully dissolved; do not strain or filter. The resulting mixture contains 0.16% (1 packet), 0.32% (2 packets), or 0.48% (3 packets) aluminum acetate and is ready for use For use as a soak: – soak affected area for 15 to 30 minutes as needed, or as directed by a doctor – repeat 3 times a day or as directed by a doctor – discard solution after each use. For use as a compress or wet dressing: – soak a clean, soft cloth in the solution. – apply cloth loosely to affected area for 15 to 30 minutes – repeat as needed or as directed by a doctor – discard solution after each use
Route of Administration: Topical
Burow's solution (13% aluminum subacetate) is active against S. aureus and P. aeruginosa, resulting in damage to the cell wall.
Substance Class Chemical
Created
by admin
on Sat Jun 26 04:19:53 UTC 2021
Edited
by admin
on Sat Jun 26 04:19:53 UTC 2021
Record UNII
3XHB1D032B
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ALUMINUM CATION
Common Name English
ALUMINIUM, ION (AL3+)
Common Name English
ALUMINUM ION
Common Name English
ALUMUNUM ION
Common Name English
ALUMINUM(III)
Systematic Name English
AL3+
Common Name English
ALUMINUM(III) ION
Common Name English
ALUMINUM(3+)
Systematic Name English
ALUMINIUM CATION
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C68232
Created by admin on Sat Jun 26 04:19:53 UTC 2021 , Edited by admin on Sat Jun 26 04:19:53 UTC 2021
NCI_THESAURUS C597
Created by admin on Sat Jun 26 04:19:53 UTC 2021 , Edited by admin on Sat Jun 26 04:19:53 UTC 2021
Code System Code Type Description
NCI_THESAURUS
C68233
Created by admin on Sat Jun 26 04:19:53 UTC 2021 , Edited by admin on Sat Jun 26 04:19:53 UTC 2021
PRIMARY
PUBCHEM
104727
Created by admin on Sat Jun 26 04:19:53 UTC 2021 , Edited by admin on Sat Jun 26 04:19:53 UTC 2021
PRIMARY
RXCUI
1546162
Created by admin on Sat Jun 26 04:19:53 UTC 2021 , Edited by admin on Sat Jun 26 04:19:53 UTC 2021
PRIMARY RxNorm
DRUG BANK
DB14519
Created by admin on Sat Jun 26 04:19:53 UTC 2021 , Edited by admin on Sat Jun 26 04:19:53 UTC 2021
PRIMARY
FDA UNII
3XHB1D032B
Created by admin on Sat Jun 26 04:19:53 UTC 2021 , Edited by admin on Sat Jun 26 04:19:53 UTC 2021
PRIMARY
CAS
22537-23-1
Created by admin on Sat Jun 26 04:19:53 UTC 2021 , Edited by admin on Sat Jun 26 04:19:53 UTC 2021
PRIMARY
Related Record Type Details
ACTIVE MOIETY