Details
Stereochemistry | ACHIRAL |
Molecular Formula | Al |
Molecular Weight | 26.9815 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 3 |
SHOW SMILES / InChI
SMILES
[Al+3]
InChI
InChIKey=REDXJYDRNCIFBQ-UHFFFAOYSA-N
InChI=1S/Al/q+3
Molecular Formula | Al |
Molecular Weight | 26.9815 |
Charge | 3 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: http://www.domeboro.com/about-domeboro/Curator's Comment: Description was created based on several sources, including
https://www.google.com/patents/US2824042 | https://www.ncbi.nlm.nih.gov/pubmed/22718290 | https://www.ncbi.nlm.nih.gov/pubmed/15516810 | https://www.ncbi.nlm.nih.gov/pubmed/10211213 | https://www.drugs.com/monograph/aluminum-acetate.html
Sources: http://www.domeboro.com/about-domeboro/
Curator's Comment: Description was created based on several sources, including
https://www.google.com/patents/US2824042 | https://www.ncbi.nlm.nih.gov/pubmed/22718290 | https://www.ncbi.nlm.nih.gov/pubmed/15516810 | https://www.ncbi.nlm.nih.gov/pubmed/10211213 | https://www.drugs.com/monograph/aluminum-acetate.html
Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations. At present the oflicial U. S. P. procedure to made Burow's solution involves the reaction of aluminum sulfate, calcium carbonate and acetic acid to form aluminum sub-acetate, also termed basic aluminum acetate.
The solution is available as an over-the-counter drug for topical administration, with brand names including Domeboro. Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. It is active against bacteria resulting in damage to the cell wall.
Originator
Sources: http://www.domeboro.com/about-domeboro/
Curator's Comment: Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2364031 |
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Target ID: GO:0042310 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | DOMEBORO Approved UseTemporarily relieves minor skin irritations due to:
– Poison ivy | – Poison oak
– Poison sumac | – Insect bites
– Athlete’s foot | – Rashes caused by soaps, detergents, cosmetics, or jewelry |
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Curative | DOMEBORO Approved UseThis medication is used to treat an outer ear infection (external otitis). This product contains acetic acid/aluminum acetate, a combination that stops the growth of bacteria and fungus. Treating the infection reduces pain and swelling in the ear. Wetness in the ear canal can help bacteria and fungus to grow. This medication also causes drying of the ear canal, helping to cure the infection. |
PubMed
Title | Date | PubMed |
---|---|---|
The ineffectiveness of aluminum subacetate in rheumatoid arthritis. | 1948 Apr 8 |
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Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study. | 1999 May |
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Fluoride plus aluminum: useful tools in laboratory investigations, but messengers of false information. | 2002 |
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Aluminum as a toxicant. | 2002 Aug |
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The giant protein HERC1 is recruited to aluminum fluoride-induced actin-rich surface protrusions in HeLa cells. | 2004 Feb 13 |
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[Pharmaceutical and pharmacological evaluation of Burow's solution (aluminum acetate solution), hospital preparation, and development of its rapid preparation method]. | 2004 Nov |
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An effector domain mutant of Arf6 implicates phospholipase D in endosomal membrane recycling. | 2006 Jan |
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The role of aluminum and copper on neuroinflammation and Alzheimer's disease. | 2006 Nov |
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Reversible myocardial injury associated with aluminum phosphide poisoning. | 2007 Sep |
Sample Use Guides
DOMEBORO® SOOTHING SOAK
– dissolve 1 to 3 packets in a pint (16 oz) of cool or warm water
– stir until fully dissolved; do not strain or filter. The resulting mixture contains 0.16% (1 packet), 0.32% (2 packets), or 0.48% (3 packets) aluminum acetate and is ready for use
For use as a soak:
– soak affected area for 15 to 30 minutes as needed, or as directed by a doctor
– repeat 3 times a day or as directed by a doctor
– discard solution after each use.
For use as a compress or wet dressing:
– soak a clean, soft cloth in the solution.
– apply cloth loosely to affected area for 15 to 30 minutes
– repeat as needed or as directed by a doctor
– discard solution after each use
Route of Administration:
Topical
Substance Class |
Chemical
Created
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admin
on
Edited
Fri Dec 15 16:06:13 GMT 2023
by
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on
Fri Dec 15 16:06:13 GMT 2023
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Record UNII |
3XHB1D032B
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Record Status |
Validated (UNII)
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C68232
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C597
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