ALUMINUM CATION

US Approved OTC

Details

Stereochemistry	ACHIRAL
Molecular Formula	Al
Molecular Weight	26.9815386
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	3

SHOW SMILES / InChI

Structure Search

SMILES

[Al+3]

InChI

InChIKey=REDXJYDRNCIFBQ-UHFFFAOYSA-N

InChI=1S/Al/q+3

HIDE SMILES / InChI

Molecular Formula	Al
Molecular Weight	26.9815386
Charge	3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.domeboro.com/about-domeboro/
Curator's Comment: Description was created based on several sources, including https://www.google.com/patents/US2824042 | https://www.ncbi.nlm.nih.gov/pubmed/22718290 | https://www.ncbi.nlm.nih.gov/pubmed/15516810 | https://www.ncbi.nlm.nih.gov/pubmed/10211213 | https://www.drugs.com/monograph/aluminum-acetate.html

Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations. At present the oflicial U. S. P. procedure to made Burow's solution involves the reaction of aluminum sulfate, calcium carbonate and acetic acid to form aluminum sub-acetate, also termed basic aluminum acetate. The solution is available as an over-the-counter drug for topical administration, with brand names including Domeboro. Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. It is active against bacteria resulting in damage to the cell wall.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cell membrane 40 Target ID: CHEMBL2364031 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22718290 \| https://www.ncbi.nlm.nih.gov/pubmed/10211213	Interacts 323
vasoconstriction 30 Target ID: GO:0042310 Sources: https://www.drugs.com/monograph/aluminum-acetate.html	Activator 1447

Conditions

Condition	Modality	Targets	Highest Phase	Product
Itching 52 Sources: http://www.domeboro.com/about-domeboro/ https://www.drugs.com/monograph/aluminum-acetate.html	Primary		Approved 8583	DOMEBORO Approved Use Temporarily relieves minor skin irritations due to: – Poison ivy \| – Poison oak – Poison sumac \| – Insect bites – Athlete’s foot \| – Rashes caused by soaps, detergents, cosmetics, or jewelry
Otitis 38 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15516810 https://www.ncbi.nlm.nih.gov/pubmed/14724484 https://www.drugs.com/monograph/aluminum-acetate.html	Curative		Approved 8583	DOMEBORO Approved Use This medication is used to treat an outer ear infection (external otitis). This product contains acetic acid/aluminum acetate, a combination that stops the growth of bacteria and fungus. Treating the infection reduces pain and swelling in the ear. Wetness in the ear canal can help bacteria and fungus to grow. This medication also causes drying of the ear canal, helping to cure the infection.

PubMed

Title	Date	PubMed
Aluminum as a toxicant.	2002 Aug	15068131
Aluminum inclusion macrophagic myofasciitis: a recently identified condition.	2003 Nov	14753387
The role of metals in neurodegenerative processes: aluminum, manganese, and zinc.	2003 Nov 15	14596888
Parenteral nutrition-associated cholestasis in neonates: the role of aluminum.	2003 Sep	14552065
Intracellular mechanisms underlying aluminum-induced apoptosis in rabbit brain.	2003 Sep 15	14507471
Aluminum: new recognition of an old problem.	2005 Dec	16198633
Effects of aluminum on the nervous system and its possible link with neurodegenerative diseases.	2005 Nov	16308486
Aluminum and Alzheimer's disease, a personal perspective after 25 years.	2006	17004365
Some aspects of astroglial functions and aluminum implications for neurodegeneration.	2006 Aug 30	16529821
Aluminum and other metals in Alzheimer's disease: a review of potential therapy with chelating agents.	2006 Nov	17119296
Blood-brain barrier flux of aluminum, manganese, iron and other metals suspected to contribute to metal-induced neurodegeneration.	2006 Nov	17119290
Aluminum and Alzheimer's disease: a new look.	2006 Nov	17119287
The role of aluminum and copper on neuroinflammation and Alzheimer's disease.	2006 Nov	17119285
Mechanisms of aluminum-induced neurodegeneration in animals: Implications for Alzheimer's disease.	2006 Nov	17119283
Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation.	2007 Oct	17931150
Ablative laser resurfacing: high-energy pulsed carbon dioxide and erbium:yttrium-aluminum-garnet.	2007 Sep-Oct	17870524
Gene expression profile of mouse fibroblasts exposed to a biodegradable iron alloy for stents.	2013 Nov	23499988

Patents

Sample Use Guides

In Vivo Use Guide

DOMEBORO® SOOTHING SOAK – dissolve 1 to 3 packets in a pint (16 oz) of cool or warm water – stir until fully dissolved; do not strain or filter. The resulting mixture contains 0.16% (1 packet), 0.32% (2 packets), or 0.48% (3 packets) aluminum acetate and is ready for use For use as a soak: – soak affected area for 15 to 30 minutes as needed, or as directed by a doctor – repeat 3 times a day or as directed by a doctor – discard solution after each use. For use as a compress or wet dressing: – soak a clean, soft cloth in the solution. – apply cloth loosely to affected area for 15 to 30 minutes – repeat as needed or as directed by a doctor – discard solution after each use

Route of Administration: Topical

In Vitro Use Guide

Burow's solution (13% aluminum subacetate) is active against S. aureus and P. aeruginosa, resulting in damage to the cell wall.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:19:04 GMT 2025` Edited by `admin` on `Mon Mar 31 18:19:04 GMT 2025`
Record UNII	3XHB1D032B
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ALUMINUM CATION

Common Name

English

AL3+

Preferred Name

English

ALUMINIUM, ION (AL3+)

Common Name

English

ALUMINUM ION

Common Name

English

ALUMUNUM ION

Common Name

English

ALUMINUM(III)

Systematic Name

English

ALUMINUM(III) ION

Common Name

English

ALUMINUM(3+)

Systematic Name

English

ALUMINIUM CATION

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C68232