CETRAXATE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H23NO4.ClH
Molecular Weight	341.83
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.NC[C@H]1CC[C@@H](CC1)C(=O)OC2=CC=C(CCC(O)=O)C=C2

InChI

InChIKey=USROQQUKEBHOFF-SKKCDYJJSA-N

InChI=1S/C17H23NO4.ClH/c18-11-13-1-6-14(7-2-13)17(21)22-15-8-3-12(4-9-15)5-10-16(19)20;/h3-4,8-9,13-14H,1-2,5-7,10-11,18H2,(H,19,20);1H/t13-,14-;

HIDE SMILES / InChI

Description
Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1931
Curator's Comment: description was created based on several sources, including: http://www.229877.com/article/2016/0303/article_36173.html | https://www.ncbi.nlm.nih.gov/pubmed/4261023

Cetraxate is an oral gastrointestinal medication, mucosal protectant. Cetraxate might indirectly stimulate capsaicin-sensitive afferent nerves and increase mucosal blood flow, and that this may be a key mechanism underlying its gastroprotective action. Cetraxate prevents gastric mucosal blood flow decrease in H. pylori-infected patients. It is usually used to improve gastric mucosal lesion in acute gastritis or acute exacerbation of chronic gastritis and to treat gastric ulcer. The most commonly reported adverse reactions include constipation, rash, nausea, vomiting, dry mouth and diarrhea.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Trypsin 7 Target ID: CHEMBL2095204 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4261023	Inhibitor 8297
UDP-galactosyltransferase (rat) 2 Target ID: UDP-galactosyltransferase (rat) Sources: https://www.ncbi.nlm.nih.gov/pubmed/9359921	Activator 1430
Prostaglandin Synthesis and Regulation 6 Target ID: WP1111 Sources: http://en.pharmacodia.com/web/drug/1_18820.html \| https://www.ncbi.nlm.nih.gov/pubmed/2305206	Modulator 828

Conditions

Condition	Modality	Targets	Highest Phase	Product
Gastritis 45 Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1931	Primary		Approved 8429	Neuer Approved Use It is usually used to improve gastric mucosal lesion in acute gastritis or acute exacerbation of chronic gastritis and to treat gastric ulcer.
Gastric ulcer 67 Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1931	Primary		Approved 8429	Neuer Approved Use It is usually used to improve gastric mucosal lesion in acute gastritis or acute exacerbation of chronic gastritis and to treat gastric ulcer.

PubMed

Title	Date	PubMed
Biocatalytic deprotection of a cetraxate ester by Microbacterium sp. strain 7-1W cells.	2003 Jan	12619695
Comparison of cetraxate-based and pantoprazole-based triple therapies in the treatment of Helicobacter pylori infection.	2004 Apr	15244013
DA-9601 for erosive gastritis: results of a double-blind placebo-controlled phase III clinical trial.	2004 Aug 15	15285023
Efficacy of triple therapy plus cetraxate for the Helicobacter pylori eradication in partial gastrectomy patients.	2005 May	15906755
15th anniversary of rebamipide: looking ahead to the new mechanisms and new applications.	2005 Oct	16184418

Patents

Sample Use Guides

In Vivo Use Guide

200 mg 3-4 times per day

Route of Administration: Oral

In Vitro Use Guide

The amounts of Cetraxate to prolong the recalcification time of citrated plasma to 2 times were approximately 50 ug in the ordinary glass tube and 25 ug in the siliconized tube.

Name

Type

Language

CETRAXATE HYDROCHLORIDE

Official Name

English

BENZENEPROPANOIC ACID, 4-(((4-(AMINOMETHYL)CYCLOHEXYL)CARBONYL)OXY)-, HYDROCHLORIDE, TRANS-

Common Name

English

DV-1006

Code

English

P-HYDROXYHYDROCINNAMIC ACID TRANS-4-(AMINOMETHYL)CYCLOHEXANECARBOXYLATE, HYDROCHLORIDE

Common Name

English

NEUER

Brand Name

English

CETRAXATE HCL

Common Name

English

CETRAXATE HYDROCHLORIDE [USAN]

Common Name

English

CETRAXATE HYDROCHLORIDE [JAN]

Common Name

English

CETRAXATE HYDROCHLORIDE [MART.]

Common Name

English

CETRAXATE HYDROCHLORIDE [MI]

Common Name

English

Cetraxate hydrochloride [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28197