Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C14H27O2.Na |
| Molecular Weight | 250.3527 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].CCCCCCCCCCCCCC([O-])=O
InChI
InChIKey=JUQGWKYSEXPRGL-UHFFFAOYSA-M
InChI=1S/C14H28O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16;/h2-13H2,1H3,(H,15,16);/q;+1/p-1
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/9323584 | https://elibrary.ru/item.asp?id=5420911 | http://www.tuscany-diet.net/lipids/list-of-fatty-acids/myristic/ | https://www.ncbi.nlm.nih.gov/pubmed/19154695 | https://www.ncbi.nlm.nih.gov/pubmed/20634506https://www.ewg.org/skindeep/ingredient/706137/SODIUM_MYRISTATE/ | Burdock, G.A. (1997) Encyclopedia of Food and Color Additives, page 2575, retrieved from: https://books.google.ru/books?id=NtaR9i3hYCYC | Igoe, R.S. (2013) Dictionary of Food Ingredients, page 129, retrieved from: https://books.google.ru/books?id=WEKEBwAAQBAJDOI: 10.1016/0378-5173(89)90003-3
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9323584 | https://elibrary.ru/item.asp?id=5420911 | http://www.tuscany-diet.net/lipids/list-of-fatty-acids/myristic/ | https://www.ncbi.nlm.nih.gov/pubmed/19154695 | https://www.ncbi.nlm.nih.gov/pubmed/20634506https://www.ewg.org/skindeep/ingredient/706137/SODIUM_MYRISTATE/ | Burdock, G.A. (1997) Encyclopedia of Food and Color Additives, page 2575, retrieved from: https://books.google.ru/books?id=NtaR9i3hYCYC | Igoe, R.S. (2013) Dictionary of Food Ingredients, page 129, retrieved from: https://books.google.ru/books?id=WEKEBwAAQBAJDOI: 10.1016/0378-5173(89)90003-3
Ammonium myristate is passage-delaying substance. It was used as a substance for influencing gastrointestinal passage. The addition of ammonium myristate caused a delay of about 1.5 h in the transit time of the absorbing part of the gastrointestinal tract. The addition of ammonium myristate improves the availability of nitrofurantoin from a slow releasing dosage form - an average increase is 23.8% of the total amount of nitrofurantoin excreted in the urine compared to the values obtained from the reference dosage form without the additional substance. The kinetics of renal elimination of nitrofurantoin is characterized by the longer duration of urinary excretion.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Longitudinal study of fatty acids in plasma and erythrocyte phospholipids during pregnancy. | 2001 |
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| Final report on the safety assessment of Cocoyl Sarcosine, Lauroyl Sarcosine, Myristoyl Sarcosine, Oleoyl Sarcosine, Stearoyl Sarcosine, Sodium Cocoyl Sarcosinate, Sodium Lauroyl Sarcosinate, Sodium Myristoyl Sarcosinate, Ammonium Cocoyl Sarcosinate, and Ammonium Lauroyl Sarcosinate. | 2001 |
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| Functional analysis of ADP-ribosylation factor (ARF) guanine nucleotide exchange factors Gea1p and Gea2p in yeast. | 2001 |
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| Structural basis of non-specific lipid binding in maize lipid-transfer protein complexes revealed by high-resolution X-ray crystallography. | 2001 Apr 27 |
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| Flunitrazepam, a 7-nitro-1,4-benzodiazepine that is unable to bind to the indole-benzodiazepine site of human serum albumin. | 2001 Apr 7 |
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| Fatty acid synthesis in African trypanosomes: a solution to the myristate mystery. | 2001 Aug |
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| A new double coupling system: synthesis of citronellyl acetate via transacetylation to citronellol from acetyl coenzyme A produced from glucose and free fatty acids. | 2001 Aug |
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| Role of AKT kinase in sphingosine-induced apoptosis in human hepatoma cells. | 2001 Aug |
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| Biosynthesis and structural characterization of medium-chain-length poly(3-hydroxyalkanoates) produced by Pseudomonas aeruginosa from fatty acids. | 2001 Aug 20 |
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| beta-Ketoacyl-[acyl carrier protein] synthase I of Escherichia coli: aspects of the condensation mechanism revealed by analyses of mutations in the active site pocket. | 2001 Aug 21 |
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| Overexpression of the myristoylated alanine-rich C-kinase substrate inhibits cell adhesion to extracellular matrix components. | 2001 Aug 24 |
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| Regulation of Golgi structure and function by ARF-like protein 1 (Arl1). | 2001 Dec |
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| Palmitate decreases proton pumping of liver-type cytochrome c oxidase. | 2001 Dec |
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| Characterization of the binding of Photobacterium phosphoreum P-flavin by Vibrio harveyi Luciferase. | 2001 Dec 15 |
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| Cellular and viral Fos proteins are degraded by different proteolytic systems. | 2001 Feb 22 |
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| Activation of ion-conducting pathways in the inner mitochondrial membrane - an unrecognized activity of fatty acid? | 2001 Feb 23 |
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| [Determination of higher fatty acids in human plasma]. | 2001 Jul |
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| Molecular characterization of StCDPK1, a calcium-dependent protein kinase from Solanum tuberosum that is induced at the onset of tuber development. | 2001 Jul |
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| Fatty acid remodeling of glycosyl phosphatidylinositol anchors in Trypanosoma brucei: incorporation of fatty acids other than myristate. | 2001 Jul |
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| HIV-1 Nef promotes survival of myeloid cells by a Stat3-dependent pathway. | 2001 Jul 6 |
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| Cellular and subcellular localization, N-terminal acylation, and calcium binding of Caenorhabditis elegans protein phosphatase with EF-hands. | 2001 Jul 6 |
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| Differential mechanisms of glucose and palmitate in augmentation of insulin secretion in mouse pancreatic islets. | 2001 Jun |
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| Cox-2 inhibitory effects of naturally occurring and modified fatty acids. | 2001 Jun |
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| Copper-catalyzed coupling of arylboronic acids and amines. | 2001 Jun 28 |
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| Crystallographic phasing of myristoyl-CoA-protein N-myristoyltransferase using an iodinated analog of myristoyl-CoA. | 2001 Mar |
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| Regulation of G proteins by covalent modification. | 2001 Mar 26 |
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| N-terminal myristylation of HBV preS1 domain enhances receptor recognition. | 2001 May |
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| Morbid myristoylation. | 2001 May |
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| Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis. | 2001 May 29 |
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| Fatty acid profiles of nitrite-oxidizing bacteria reflect their phylogenetic heterogeneity. | 2001 Nov |
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| Enzyme activity of the cytochrome P-450 monooxygenase system in the presence of single chain lipid molecules. | 2001 Nov-Dec |
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| Effects of incubator humidity and hen age on yolk composition in broiler hatching eggs from young breeders. | 2001 Oct |
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| Ethanol- and nicotine-induced membrane changes in embryonic and neonatal chick brains. | 2001 Oct |
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| Deletion of N-terminal myristoylation site of HIV Nef abrogates both MHC-1 and CD4 down-regulation. | 2001 Oct 1 |
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| Propranolol increases phosphatidic acid level via activation of phospholipase D. | 2001 Sep |
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| Rat pancreatic acinar cells express a cytosolic phospholipase D1b isoform that is not regulated by cholecystokinin. | 2001 Sep |
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| Optimization of carbohydrate fatty acid ester synthesis in organic media by a lipase from Candida antarctica. | 2001 Sep 20 |
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| Differential effect of valproate and its Delta2- and Delta4-unsaturated metabolites, on the beta-oxidation rate of long-chain and medium-chain fatty acids. | 2001 Sep 28 |
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| Coexpression of proteins with methionine aminopeptidase and/or N-myristoyltransferase in Escherichia coli to increase acylation and homogeneity of protein preparations. | 2002 |
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| Differential use of myristoyl groups on neuronal calcium sensor proteins as a determinant of spatio-temporal aspects of Ca2+ signal transduction. | 2002 Apr 19 |
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| Myristoylated alanine-rich C kinase substrate (MARCKS) sequesters spin-labeled phosphatidylinositol 4,5-bisphosphate in lipid bilayers. | 2002 Apr 19 |
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| Myristyl and palmityl acylation of pI 5.1 carboxylesterase from porcine intestine and liver. | 2002 Feb |
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| Differences in the fatty acid composition of larvae and metamorphosing sea lampreys, Petromyzon marinus. | 2002 Feb |
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| Oxidative stress induced cytokine production in isolated rat pancreatic acinar cells: effects of small-molecule antioxidants. | 2002 Feb |
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| Serum free fatty acid pattern and risk of myocardial infarction: a case-control study. | 2002 Jan |
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| [Fatty acid-induced reversal of general anesthesia: chain length-dependence of antagonizing potencies of fatty acids]. | 2002 Jan |
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| Intrastriatal injection of sonic hedgehog reduces behavioral impairment in a rat model of Parkinson's disease. | 2002 Jan |
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| Permeation of a myristoylated dipeptide across the buccal mucosa: topological distribution and evaluation of tissue integrity. | 2002 Jan 1 |
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| Interaction of bovine (BSA) and human (HSA) serum albumins with ionic surfactants: spectroscopy and modelling. | 2002 Jan 31 |
|
| The linker domain of the Ha-Ras hypervariable region regulates interactions with exchange factors, Raf-1 and phosphoinositide 3-kinase. | 2002 Jan 4 |
Patents
Sample Use Guides
Rous sarcoma virus-transformed cells were labeled for 2 h with either 1 mCi of [3H]palmitic acid or 0.2 mCi of [3H]myristic acid, and p60src was isolated by immunoprecipitation. The incorporation of [3H]myristic acid into p60src was ca. 100-fold greater than the incorporation of [3H]palmitic acid.
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JECFA EVALUATION |
INS-470(I)
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CODEX ALIMENTARIUS (GSFA) |
INS-470(I)
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1744165
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Sodium myristate
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06BLC4V0IV
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06BLC4V0IV
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212-487-9
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DTXSID5042455
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23693095
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822-12-8
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PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
