U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Showing 1 - 9 of 9 results

Status:
Investigational

Class (Stereo):
CHEMICAL (ACHIRAL)

Mitoflaxone, also known as flavone acetic acid is a synthetic flavonoid that has been studied as an antitumor agent. Mitoflaxone was involved in phase II clinical trials in Europe for patients with advanced colorectal carcinoma and for patients with ...
Status:
Investigational

Class (Stereo):
CHEMICAL (ABSOLUTE)

Vatiquinone is the international non-proprietary name for Edison Pharmaceuticals’ EPI-743, an orally bioavailable small molecule being developed by the company for inherited mitochondrial diseases. EPI-743 is a member of the para-benzoquinone class o...
Status:
Investigational

Class (Stereo):
CHEMICAL (MIXED)

Tocofenoxate is a semisynthetic tocopherol derivative. Vitamin E supplement.
Status:
Investigational

Class (Stereo):
CHEMICAL (ACHIRAL)



Vadimezan (5,6-dimethyl(xanthenone-4-acetic acid), ASA404, DMXAA) is a fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity. In pre-clinical mouse tumour models it was demonstrated that administration of Vadimezan ra...
Status:
US Previously Marketed
First approved in 1953

Class (Stereo):
CHEMICAL (ACHIRAL)



Quercetin is a unique bioflavonoid that has been extensively studied by researchers over the past 30 years. Quercetin, the most abundant of the flavonoids (the name comes from the Latin –quercetum, meaning oak forest, quercus oak) consists of 3 rings...
Status:
Possibly Marketed Outside US
First approved in 2012

Class (Stereo):
CHEMICAL (ABSOLUTE)



Diosmin is a flavone indicated for the treatment of venous disease i.e., chronic venous insufficiency (CVI) including spider and varicose veins, leg swelling (edema), stasis dermatitis and venous ulcers. Diosmin is also used as a stand-alone or sur...
Status:
Possibly Marketed Outside US
First approved in 2007

Class (Stereo):
CHEMICAL (ABSOLUTE)

Vitamin E quinone Alpha-tocopherylquinone is formed during free radical attack on vitamin E and has been shown to undergo reduction by NQO1 (NAD(P)H dehydrogenase [quinone] 1) to generate vitamin E hydroquinone. Since it has been recognized that alph...
Status:
Possibly Marketed Outside US
First approved in 1992

Class (Stereo):
CHEMICAL (ABSOLUTE)



Glabridin is an isoflavane found in the root extract of licorice (Glycyrrhiza glabra). Glabridin is considered to be a phytoestrogen and has been associated with numerous biological properties ranging from antioxidant, anti-inflammatory, neuroprotect...
structurally diverse
Status:
US Previously Marketed
First marketed in 1921

Class:
STRUCTURALLY DIVERSE


Hesperidin is a flavanone glycoside found in citrus fruits. Its aglycone form is called hesperetin. Its name is derived from the word "hesperidium", for fruit produced by citrus trees. Hesperidin was first isolated in 1828 by French chemist Lebreton ...