Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C29H50O3 |
Molecular Weight | 446.7055 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 3 / 3 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@@](C)(O)CCC1=C(C)C(=O)C(C)=C(C)C1=O
InChI
InChIKey=LTVDFSLWFKLJDQ-IEOSBIPESA-N
InChI=1S/C29H50O3/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8,32)19-17-26-25(7)27(30)23(5)24(6)28(26)31/h20-22,32H,9-19H2,1-8H3/t21-,22-,29-/m1/s1
Vitamin E quinone Alpha-tocopherylquinone is formed during free radical attack on vitamin E and has been shown to undergo reduction by NQO1 (NAD(P)H dehydrogenase [quinone] 1) to generate vitamin E hydroquinone. Since it has been recognized that alpha-tocopherylquinone in living tissue for global assessment of antioxidative defense system. The ratio of alpha-tocopherol alpha-tocopherylquinone concentrations were increased under oxidative stress with the exception of plasma. Alpha-tocopherylquinone and a low fat diet have positive effect on a patient with chronic continuous ulcerative colitis. The patient's condition improved dramatically with both colonic and extraintestinal manifestations of the disease. Withdrawal of alpha-tocopherylquinone for periods of one to two days produced recurrence of inflammation, which was again reduced upon re-introduction of alpha-tocopherylquinone.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3721293
3.0 g/day (50 mg/kg/d) or greater
Route of Administration:
Oral
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NCI_THESAURUS |
C942
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7559-04-8
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231-450-8
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ZO763K43XR
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100000178273
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SUB193910
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C126913
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DTXSID501009892
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DB14094
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2734086
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1376149
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ZO763K43XR
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ACTIVE MOIETY