MITOFLAXONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H12O4
Molecular Weight	280.2748
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)CC1=CC=CC2=C1OC(=CC2=O)C3=CC=CC=C3

InChI

InChIKey=TZZNWMJZDWYJAZ-UHFFFAOYSA-N

InChI=1S/C17H12O4/c18-14-10-15(11-5-2-1-3-6-11)21-17-12(9-16(19)20)7-4-8-13(14)17/h1-8,10H,9H2,(H,19,20)

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2370185 | https://www.ncbi.nlm.nih.gov/pubmed/3545524 | https://adisinsight.springer.com/drugs/800000745 | https://www.ncbi.nlm.nih.gov/pubmed/2803908

Mitoflaxone, also known as flavone acetic acid is a synthetic flavonoid that has been studied as an antitumor agent. Mitoflaxone was involved in phase II clinical trials in Europe for patients with advanced colorectal carcinoma and for patients with advanced malignant melanoma. Despite the promising preclinical activity, this drug didn’t demonstrate any clinical activity. Further studies of the drug were suspended.

Originator

Approval Year

PubMed

Title	Date	PubMed
5,6-dimethylxanthenone-4-acetic acid (DMXAA): a new biological response modifier for cancer therapy.	2002 Aug	12201491
Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer.	2008 Dec 16	19078952

Sample Use Guides

In Vivo Use Guide

Sixteen patients (9 men, 7 women) were given FAA (MITOFLAXONE ) as 6-h i.v. infusions 2 or 3 times a week (10 and 6 patients, respectively), at doses ranging from 2.5 to 8.1 g/m2

Route of Administration: Intravenous

Name

Type

Language

MITOFLAXONE

Official Name

English

NSC-347512

Code

English

FLAVONE-8-ACETIC ACID

Systematic Name

English

4-OXO-2-PHENYL-4H-1-BENZOPYRAN-8-ACETIC ACID

Systematic Name

English

mitoflaxone [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C306