Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C17H12O4 |
| Molecular Weight | 280.2748 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)CC1=CC=CC2=C1OC(=CC2=O)C3=CC=CC=C3
InChI
InChIKey=TZZNWMJZDWYJAZ-UHFFFAOYSA-N
InChI=1S/C17H12O4/c18-14-10-15(11-5-2-1-3-6-11)21-17-12(9-16(19)20)7-4-8-13(14)17/h1-8,10H,9H2,(H,19,20)
Mitoflaxone, also known as flavone acetic acid is a synthetic flavonoid that has been studied as an antitumor agent. Mitoflaxone was involved in phase II clinical trials in Europe for patients with advanced colorectal carcinoma and for patients with advanced malignant melanoma. Despite the promising preclinical activity, this drug didn’t demonstrate any clinical activity. Further studies of the drug were suspended.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias. | 2000 May |
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| The antitumour activity of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF receptor-1 knockout mice. | 2002 Aug 12 |
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| Synthesis and biological evaluation of 3-alkoxy analogues of flavone-8-acetic acid. | 2003 Aug 14 |
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| Fundamental, electron transfer mechanism by pyrylium-type ions for the anticancer drugs 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA). | 2005 Sep |
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| Zolpidem, a clinical hypnotic that affects electronic transfer, alters synaptic activity through potential GABA receptors in the nervous system without significant free radical generation. | 2009 Jan-Mar |
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NCI_THESAURUS |
C306
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55748
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CHEMBL443793
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C1101
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6348
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347512
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
