Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C17H11O4.Na |
| Molecular Weight | 302.2566 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[O-]C(=O)CC1=CC=CC2=C1OC(=CC2=O)C3=CC=CC=C3
InChI
InChIKey=IXVASPMKXYVFLK-UHFFFAOYSA-M
InChI=1S/C17H12O4.Na/c18-14-10-15(11-5-2-1-3-6-11)21-17-12(9-16(19)20)7-4-8-13(14)17;/h1-8,10H,9H2,(H,19,20);/q;+1/p-1
| Molecular Formula | Na |
| Molecular Weight | 22.98976928 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C17H11O4 |
| Molecular Weight | 279.2668 |
| Charge | -1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Mitoflaxone, also known as flavone acetic acid is a synthetic flavonoid that has been studied as an antitumor agent. Mitoflaxone was involved in phase II clinical trials in Europe for patients with advanced colorectal carcinoma and for patients with advanced malignant melanoma. Despite the promising preclinical activity, this drug didn’t demonstrate any clinical activity. Further studies of the drug were suspended.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Immune-modulating and anti-vascular activities of two xanthenone acetic acid analogues: A comparative study to DMXAA. | 2009-01 |
|
| Zolpidem, a clinical hypnotic that affects electronic transfer, alters synaptic activity through potential GABA receptors in the nervous system without significant free radical generation. | 2008-12-19 |
|
| Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer. | 2008-12-16 |
|
| Identification of new flavone-8-acetic acid metabolites using mouse microsomes and comparison with human microsomes. | 2007-11 |
|
| Vascular disrupting agents in clinical development. | 2007-04-23 |
|
| Characterization of monohydroxylated derivatives of the anticancer agent flavone-8-acetic acid by liquid chromatography with on-line UV and mass spectrometry. | 2007 |
|
| Fundamental, electron transfer mechanism by pyrylium-type ions for the anticancer drugs 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA). | 2005-09 |
|
| Mono- or di-fluorinated analogues of flavone-8-acetic acid: synthesis and in vitro biological activity. | 2005-05-05 |
|
| Synthesis and biological evaluation of novel flavone-8-acetic acid derivatives as reversible inhibitors of aminopeptidase N/CD13. | 2003-08-28 |
|
| Synthesis and biological evaluation of 3-alkoxy analogues of flavone-8-acetic acid. | 2003-08-14 |
|
| Clinical aspects of a phase I trial of 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent. | 2003-06-16 |
|
| 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent: phase I clinical and pharmacokinetic study. | 2003-04-22 |
|
| The antitumour activity of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF receptor-1 knockout mice. | 2002-08-12 |
|
| 5,6-dimethylxanthenone-4-acetic acid (DMXAA): a new biological response modifier for cancer therapy. | 2002-08 |
|
| Induction of endothelial cell apoptosis by the antivascular agent 5,6-Dimethylxanthenone-4-acetic acid. | 2002-06-17 |
|
| Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias. | 2000-05 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:24:22 GMT 2025
by
admin
on
Mon Mar 31 18:24:22 GMT 2025
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| Record UNII |
4Y8CM5OK0L
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| Record Status |
Validated (UNII)
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| Record Version |
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Created by
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