U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Status:
First approved in 1960

Class (Stereo):
CHEMICAL (ABSOLUTE)



Benzphetamine is a sympathomimetic agent with properties similar to dextroamphetamine. It is used in the management of exogenous obesity as a short term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction in patients with an initial body mass index (BMI) of 30 kg/m2 or higher who have not responded to appropriate weight reducing regimen (diet and/or exercise) alone. Presumably, benzphetamine produces its effects through mechanisms similar to amphetamine via induces synaptic vesicular amine transporter, but precise mechanism of action of benzphetamine is not known.
Status:
US Previously Marketed
Source:
Voranil by U.S. Vitamin (USV)
(1973)
Source URL:
First approved in 1973
Source:
Voranil by U.S. Vitamin (USV)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Clortermine hydrochloride (Voranil) is a non-amphetamine anorexigenic agent. Voranil, a sympathomimetic amine, is indicated for short-term adjunctive treatment of exogenous obesity. Its long duration of action permits once-a-day dosage. In a large number of patients studied, Voranil was found to be superior to placebo in weight reduction. Insomnia, dry mouth, palpitations and tachycardia have been reported in a small percentage of patients taking the drug. Voranil was originally developed by Ciba Pharmaceuticals Corporation and transferred to USV Pharmaceuticals Corporation in December 1971, as a result of a product exchange agreement.
Status:
US Previously Marketed
First approved in 1965

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Chlorphentermine exerts anorectic properties. It is a synthetic amphetamine derivatc claimed to have none of the excitatory effects of the parenit substanice. PRE-SATE (Chlorphentermine HCl) is an effective appetite suppressant with a pattern of pharmacologic action substantially different from those of traditional anorexigenics. In providing dependable appetite control with appreciable loss of bodyweight, PRE-SATE does not significantly increase central nervous system (CNS), cardiorespiratory or metabolic activity.
Status:
First approved in 1961
Source:
Plegine by Ayerst
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Phendimetrazine is an appetite suppressant that is FDA approved for the treatment of exogenous obesity. It is clinically available anorectic agent, which display minimal interactions with monoamine transporters in vitro. On the other hand, their medications is known to be psychomotor stimulants when administered in vivo as indicated by their shared properties with illicit drugs like cocaine. The following adverse reactions are described, or described in greater detail, in other sections: Primary pulmonary hypertension; Valvular heart disease; Effect on the ability to engage in potentially hazardous tasks; Withdrawal effects following prolonged high dosage administration. Use of phendimetrazine tartrate is contraindicated during or within 14 days following the administration of monoamine oxidase inhibitors because of the risk of hypertensive crisis.
Status:
First approved in 1961
Source:
Plegine by Ayerst
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Phendimetrazine is an appetite suppressant that is FDA approved for the treatment of exogenous obesity. It is clinically available anorectic agent, which display minimal interactions with monoamine transporters in vitro. On the other hand, their medications is known to be psychomotor stimulants when administered in vivo as indicated by their shared properties with illicit drugs like cocaine. The following adverse reactions are described, or described in greater detail, in other sections: Primary pulmonary hypertension; Valvular heart disease; Effect on the ability to engage in potentially hazardous tasks; Withdrawal effects following prolonged high dosage administration. Use of phendimetrazine tartrate is contraindicated during or within 14 days following the administration of monoamine oxidase inhibitors because of the risk of hypertensive crisis.
Status:
First approved in 1960

Class (Stereo):
CHEMICAL (ABSOLUTE)



Benzphetamine is a sympathomimetic agent with properties similar to dextroamphetamine. It is used in the management of exogenous obesity as a short term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction in patients with an initial body mass index (BMI) of 30 kg/m2 or higher who have not responded to appropriate weight reducing regimen (diet and/or exercise) alone. Presumably, benzphetamine produces its effects through mechanisms similar to amphetamine via induces synaptic vesicular amine transporter, but precise mechanism of action of benzphetamine is not known.
Status:
US Previously Marketed
First approved in 1965

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Chlorphentermine exerts anorectic properties. It is a synthetic amphetamine derivatc claimed to have none of the excitatory effects of the parenit substanice. PRE-SATE (Chlorphentermine HCl) is an effective appetite suppressant with a pattern of pharmacologic action substantially different from those of traditional anorexigenics. In providing dependable appetite control with appreciable loss of bodyweight, PRE-SATE does not significantly increase central nervous system (CNS), cardiorespiratory or metabolic activity.