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Details

Stereochemistry ACHIRAL
Molecular Formula C10H14ClN
Molecular Weight 183.678
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CHLORPHENTERMINE

SMILES

CC(C)(N)CC1=CC=C(Cl)C=C1

InChI

InChIKey=ZCKAMNXUHHNZLN-UHFFFAOYSA-N
InChI=1S/C10H14ClN/c1-10(2,12)7-8-3-5-9(11)6-4-8/h3-6H,7,12H2,1-2H3

HIDE SMILES / InChI

Description

Chlorphentermine exerts anorectic properties. It is a synthetic amphetamine derivatc claimed to have none of the excitatory effects of the parenit substanice. PRE-SATE (Chlorphentermine HCl) is an effective appetite suppressant with a pattern of pharmacologic action substantially different from those of traditional anorexigenics. In providing dependable appetite control with appreciable loss of bodyweight, PRE-SATE does not significantly increase central nervous system (CNS), cardiorespiratory or metabolic activity.

CNS Activity

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
338.0 nM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
PRE-SATE
PubMed

PubMed

TitleDatePubMed
The early changes in experimental myopathy induced by chloroquine and chlorphentermine.
1980 Jan
Anorexigen-induced pulmonary hypertension and the serotonin (5-HT) hypothesis: lessons for the future in pathogenesis.
2002
Screening for amphetamine and amphetamine-type drugs in doping analysis by liquid chromatography/mass spectrometry.
2006
The antidotal effects of high-dosage gamma-aminobutyric acid on acute tetramine poisoning as compared with sodium dimercaptopropane sulfonate.
2007 Aug
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Adults: 65 mg (one tablet) taken with or shortly after the first meal of the day.
Route of Administration: Oral
In Vitro Use Guide
In contrast, lymphocytes pre-incubated with 10(-5)M chlorphentermine (CP) for 60 min, then stimulated with Con A for 2 hours in the presence of 10(-5)M CP, exhibit a significantly depressed inositol phosphate formation. In addition, CP also inhibited the activity of phospholipase C (IC50 = 0.58 mM), the enzyme responsible for the formation of inositol phosphates during lymphocyte activation. Further, lymphocytes activated in a manner that bypasses the phosphatidylinositol pathway are not inhibited by 10(-7)M or 10(-9)M CP as are cells activated with Con A.
Name Type Language
CHLORPHENTERMINE
HSDB   INN   MI   WHO-DD  
INN  
Official Name English
CHLORPHENTERMINE [INN]
Common Name English
CHLORPHENTERMINE [HSDB]
Common Name English
CHLORPHENTERMINE [MI]
Common Name English
BENZENEETHANAMINE, 4-CHLORO-.ALPHA.,.ALPHA.-DIMETHYL
Common Name English
P-CHLORO-.ALPHA.,.ALPHA.-DIMETHYLPHENETHYLAMINE
Common Name English
CHLORPHENTERMINE [WHO-DD]
Common Name English
Classification Tree Code System Code
DEA NO. 1645
Created by admin on Tue Oct 22 06:08:36 UTC 2019 , Edited by admin on Tue Oct 22 06:08:36 UTC 2019
NCI_THESAURUS C47795
Created by admin on Tue Oct 22 06:08:36 UTC 2019 , Edited by admin on Tue Oct 22 06:08:36 UTC 2019
Code System Code Type Description
NCI_THESAURUS
C65323
Created by admin on Tue Oct 22 06:08:36 UTC 2019 , Edited by admin on Tue Oct 22 06:08:36 UTC 2019
PRIMARY
HSDB
461-78-9
Created by admin on Tue Oct 22 06:08:36 UTC 2019 , Edited by admin on Tue Oct 22 06:08:36 UTC 2019
PRIMARY
ECHA (EC/EINECS)
207-314-9
Created by admin on Tue Oct 22 06:08:36 UTC 2019 , Edited by admin on Tue Oct 22 06:08:36 UTC 2019
PRIMARY
MESH
D002745
Created by admin on Tue Oct 22 06:08:36 UTC 2019 , Edited by admin on Tue Oct 22 06:08:36 UTC 2019
PRIMARY
PUBCHEM
10007
Created by admin on Tue Oct 22 06:08:36 UTC 2019 , Edited by admin on Tue Oct 22 06:08:36 UTC 2019
PRIMARY
INN
1055
Created by admin on Tue Oct 22 06:08:36 UTC 2019 , Edited by admin on Tue Oct 22 06:08:36 UTC 2019
PRIMARY
EVMPD
SUB06205MIG
Created by admin on Tue Oct 22 06:08:36 UTC 2019 , Edited by admin on Tue Oct 22 06:08:36 UTC 2019
PRIMARY
ChEMBL
CHEMBL1201269
Created by admin on Tue Oct 22 06:08:36 UTC 2019 , Edited by admin on Tue Oct 22 06:08:36 UTC 2019
PRIMARY
WIKIPEDIA
Chlorphentermine
Created by admin on Tue Oct 22 06:08:36 UTC 2019 , Edited by admin on Tue Oct 22 06:08:36 UTC 2019
PRIMARY
CAS
461-78-9
Created by admin on Tue Oct 22 06:08:36 UTC 2019 , Edited by admin on Tue Oct 22 06:08:36 UTC 2019
PRIMARY
EPA CompTox
461-78-9
Created by admin on Tue Oct 22 06:08:36 UTC 2019 , Edited by admin on Tue Oct 22 06:08:36 UTC 2019
PRIMARY
MERCK INDEX
M3458
Created by admin on Tue Oct 22 06:08:36 UTC 2019 , Edited by admin on Tue Oct 22 06:08:36 UTC 2019
PRIMARY Merck Index