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Details

Stereochemistry ACHIRAL
Molecular Formula C10H14ClN.ClH
Molecular Weight 220.139
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CHLORPHENTERMINE HYDROCHLORIDE

SMILES

Cl.CC(C)(N)CC1=CC=C(Cl)C=C1

InChI

InChIKey=WEJDYJKJPUPMLH-UHFFFAOYSA-N
InChI=1S/C10H14ClN.ClH/c1-10(2,12)7-8-3-5-9(11)6-4-8;/h3-6H,7,12H2,1-2H3;1H

HIDE SMILES / InChI

Molecular Formula C10H14ClN
Molecular Weight 183.678
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/13931448 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2274216/pdf/canfamphys00340-0041.pdf

Chlorphentermine exerts anorectic properties. It is a synthetic amphetamine derivatc claimed to have none of the excitatory effects of the parenit substanice. PRE-SATE (Chlorphentermine HCl) is an effective appetite suppressant with a pattern of pharmacologic action substantially different from those of traditional anorexigenics. In providing dependable appetite control with appreciable loss of bodyweight, PRE-SATE does not significantly increase central nervous system (CNS), cardiorespiratory or metabolic activity.

CNS Activity

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
338.0 nM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
PRE-SATE

Approved Use

PRE-SATE is indicated as an adlunct in the short term (i.e. a few weeks) management of exogenous obesity and related less serious overweight conditions in conjunction with a medically supervised regimen of weight reduction based on caloric restriction.
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
0.4 μg/mL
100 mg single, oral
dose: 100 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CHLORPHENTERMINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
10.6 μg × h/mL
100 mg single, oral
dose: 100 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CHLORPHENTERMINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
41 h
100 mg single, oral
dose: 100 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CHLORPHENTERMINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FED
PubMed

PubMed

TitleDatePubMed
Chlorphentermine, a new anorectic agent.
1962 Sep
Experimental myopathy induced by amphiphilic cationic compounds including several psychotropic drugs.
1979
Patents

Patents

Sample Use Guides

Adults: 65 mg (one tablet) taken with or shortly after the first meal of the day.
Route of Administration: Oral
In Vitro Use Guide
In contrast, lymphocytes pre-incubated with 10(-5)M chlorphentermine (CP) for 60 min, then stimulated with Con A for 2 hours in the presence of 10(-5)M CP, exhibit a significantly depressed inositol phosphate formation. In addition, CP also inhibited the activity of phospholipase C (IC50 = 0.58 mM), the enzyme responsible for the formation of inositol phosphates during lymphocyte activation. Further, lymphocytes activated in a manner that bypasses the phosphatidylinositol pathway are not inhibited by 10(-7)M or 10(-9)M CP as are cells activated with Con A.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:01:26 GMT 2023
Edited
by admin
on Fri Dec 15 15:01:26 GMT 2023
Record UNII
RL11HOJ7DM
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CHLORPHENTERMINE HYDROCHLORIDE
MART.   MI   ORANGE BOOK   USAN   WHO-DD  
USAN  
Official Name English
CHLORPHENTERMINE HYDROCHLORIDE [USAN]
Common Name English
CHLORPHENTERMINE HCL
Common Name English
Chlorphentermine hydrochloride [WHO-DD]
Common Name English
P-CHLORO-.ALPHA.,.ALPHA.-DIMETHYLPHENETHYLAMINE HYDROCHLORIDE
Common Name English
NSC-76098
Code English
CHLORPHENTERMINE HYDROCHLORIDE [MI]
Common Name English
S-62
Code English
PRE-SATE
Brand Name English
W-2426
Code English
BENZENEETHANAMINE, 4-CHLORO-.ALPHA.,.ALPHA.-DIMETHYL-, HYDROCHLORIDE
Systematic Name English
CHLORPHENTERMINE HYDROCHLORIDE [ORANGE BOOK]
Common Name English
CHLORPHENTERMINE HYDROCHLORIDE [MART.]
Common Name English
W 2426
Code English
Classification Tree Code System Code
NCI_THESAURUS C47795
Created by admin on Fri Dec 15 15:01:26 GMT 2023 , Edited by admin on Fri Dec 15 15:01:26 GMT 2023
DEA NO. 1645
Created by admin on Fri Dec 15 15:01:26 GMT 2023 , Edited by admin on Fri Dec 15 15:01:26 GMT 2023
Code System Code Type Description
FDA UNII
RL11HOJ7DM
Created by admin on Fri Dec 15 15:01:26 GMT 2023 , Edited by admin on Fri Dec 15 15:01:26 GMT 2023
PRIMARY
NSC
76098
Created by admin on Fri Dec 15 15:01:26 GMT 2023 , Edited by admin on Fri Dec 15 15:01:26 GMT 2023
PRIMARY
EPA CompTox
DTXSID1047815
Created by admin on Fri Dec 15 15:01:26 GMT 2023 , Edited by admin on Fri Dec 15 15:01:26 GMT 2023
PRIMARY
NCI_THESAURUS
C65324
Created by admin on Fri Dec 15 15:01:26 GMT 2023 , Edited by admin on Fri Dec 15 15:01:26 GMT 2023
PRIMARY
ECHA (EC/EINECS)
205-782-9
Created by admin on Fri Dec 15 15:01:26 GMT 2023 , Edited by admin on Fri Dec 15 15:01:26 GMT 2023
PRIMARY
MERCK INDEX
m3458
Created by admin on Fri Dec 15 15:01:26 GMT 2023 , Edited by admin on Fri Dec 15 15:01:26 GMT 2023
PRIMARY Merck Index
PUBCHEM
65477
Created by admin on Fri Dec 15 15:01:26 GMT 2023 , Edited by admin on Fri Dec 15 15:01:26 GMT 2023
PRIMARY
ChEMBL
CHEMBL1201269
Created by admin on Fri Dec 15 15:01:26 GMT 2023 , Edited by admin on Fri Dec 15 15:01:26 GMT 2023
PRIMARY
SMS_ID
100000084738
Created by admin on Fri Dec 15 15:01:26 GMT 2023 , Edited by admin on Fri Dec 15 15:01:26 GMT 2023
PRIMARY
DRUG BANK
DBSALT000815
Created by admin on Fri Dec 15 15:01:26 GMT 2023 , Edited by admin on Fri Dec 15 15:01:26 GMT 2023
PRIMARY
EVMPD
SUB01251MIG
Created by admin on Fri Dec 15 15:01:26 GMT 2023 , Edited by admin on Fri Dec 15 15:01:26 GMT 2023
PRIMARY
CAS
151-06-4
Created by admin on Fri Dec 15 15:01:26 GMT 2023 , Edited by admin on Fri Dec 15 15:01:26 GMT 2023
PRIMARY
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