U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
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Showing 1 - 10 of 10 results

Status:
US Approved Rx (2000)
First approved in 1992

Class (Stereo):
CHEMICAL (ACHIRAL)



Atovaquone is a chemical compound that belongs to the class of naphthoquinones; it is manufactured in the US in the liquid form, or oral suspension, under the brand name Mepron. Meron is used for the treatment or prevention of Pneumocystis carinii pn...
Status:
US Approved Rx (2003)
First approved in 1989

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

Mefloquine, sold under the brand names Lariam among others, is a medication used to for the treatment of mild to moderate acute malaria caused by Mefloquineuine-susceptible strains of Plasmodium falciparum (both chloroquine-susceptible and resistant ...
Status:
US Approved Rx (2022)
First approved in 1953

Class (Stereo):
CHEMICAL (ACHIRAL)



Pyrimethamine, sold under the trade name Daraprim, is one of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. In addition it was approved in Chemoprophylaxis of Malaria. However, resistance to p...
Status:
US Approved Rx (2014)
First approved in 1952

Class (Stereo):
CHEMICAL (RACEMIC)



Primaquine is a oral medication used to treat and prevent malaria and to treat Pneumocystis pneumonia. Specifically it is used for malaria due to Plasmodium vivax and Plasmodium ovale along with other medications and for prevention if other options c...
Status:
US Approved Rx (2014)
First approved in 1947

Class (Stereo):
CHEMICAL (ACHIRAL)



Proguanil is a prophylactic antimalarial drug, which works by stopping the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. Proguanil in combination with atovaquone are marked under the...
Status:
US Approved Rx (2015)
First marketed in 1921

Class (Stereo):
CHEMICAL (ABSOLUTE)



Quinine soluble salts possess the extremely bitter taste, that may have a perplexing problem especially to children. That is why the most common combinations which are administered in this way are the sulphate, salicylate, tannate and certain esters....
Status:
US Previously Marketed
First approved in 1950

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Amodiaquine is a medication used to treat malaria, including Plasmodium falciparum malaria when uncomplicated. The mechanism of plasmodicidal action of amodiaquine is not completely certain. Like other quinoline derivatives, it is thought to inhibit ...
Status:
US Approved Rx (2009)
First approved in 2009

Class (Stereo):
CHEMICAL (RACEMIC)

Targets:

Conditions:

Lumefantrine is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with artemether for improved efficacy (Coartem tablets). Lumefantrine is a blood schizonticide active against erythrocytic stages of Pl...
Status:
US Approved Rx (2009)
First approved in 2009

Class (Stereo):
CHEMICAL (ABSOLUTE)



Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy against malaria. Artemether is rapidly metabolized into an active metabolite dihydroartemisinin (...
Status:
US Approved Rx (2011)
First approved in 1943

Class (Stereo):
CHEMICAL (RACEMIC)



Chloroquine (brand name Aralen) is indicated for the suppressive treatment and for acute attacks of malaria due to P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum. The drug is also indicated for the treatment of extraintestin...