Pararosaniline pamoate (CI 403-A) was developed as an orally active drug for the treatment of Schistosoma japonicum infection. The clinical trial has shown that capsules were safe and effective; in addition, this drug was well tolerated with a minimum of side effects, which were mostly mild and transient and did not require interruption of treatment. Besides, pararosaniline pamoate was an inhibitor of E.histolytica Hsp90 (EhHsp90) with promising activity against the parasite Pararosaniline pamoate, that causes amebiasis worldwide. Information about the current use of this drug is not available.

Rose Bengal lactone is a polyhalogenated derivative of Fluorescein. Rose Bengal lactone is a dye compound described to produce cell membrane damage. Rose Bengal lactone and other Fluorescein derivatives are also described to modulate the function of ATP-sensitive K+ channels. Rose bengal lactone reacts readily with bases so treatment with triethylamine immediately yields the Rose Bengal salt.

Oil orange SS (or FD&C orange No. 2), an azo compound that was studied as a food color. It was found that the Oil orange SS could lead to the tumors, carcinomas of the bladder.

Metanil yellow is a yellow azo dye. Due to its toxic effect on the liver, brain and reproductive organs, the use of metanil yellow in the food industry is not permitted. Despite its status, metanil yellow was found in 16.4% of the sampled food products in India. It was used to color bakery goods, cereals, beverages, candies, gelatin, and numerous other commodities. Metanil yellow is used as an adulterant for curcumin in the turmeric powder.