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National Institutes of Health
NCATS
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US Approved Rx
12
US Previously Marketed
1
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Primary Target
Cyclooxygenase-2
1
Dihydroorotate dehydrogenase
1
Dihydroorotate dehydrogenase (quinone), mitochondrial
1
Tyrosine-protein kinase JAK1
1
Tyrosine-protein kinase JAK2
1
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Highest Phase
Approved
3
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Approval Year
1997
1
1998
3
2001
2
2002
1
2005
1
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Condition
Rheumatoid arthritis
2
Active rheumatoid arthritis
1
Multiple sclerosis
1
Osteoarthritis
1
Pain, postoperative
1
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Treatment Modality
Palliative
2
Primary
2
Secondary
1
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CNS Activity
CNS Penetrant
2
CNS Non-penetrant
1
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Originator
Genzyme
1
Pfizer
1
Pfizer|National Institutes of Health
1
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Substance Class
Protein
10
Chemical
3
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Code System
CAS
13
ChEMBL
13
DRUG BANK
13
EMA ASSESSMENT REPORTS
13
EVMPD
13
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Protein Type
MONOCLONAL ANTIBODY
7
CYTOKINE
1
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ATC Level 1
ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
11
MUSCULO-SKELETAL SYSTEM
1
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ATC Level 2
IMMUNOSUPPRESSANTS
10
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
1
ANTINEOPLASTIC AGENTS
1
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ATC Level 3
IMMUNOSUPPRESSANTS
10
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
1
OTHER ANTINEOPLASTIC AGENTS
1
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ATC Level 4
Tumor necrosis factor alpha (TNF-a) inhibitors
5
Interleukin inhibitors
3
Selective immunosuppressants
2
Coxibs
1
Monoclonal antibodies
1
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Substance Form
Principal Form
10
Salts, Hydrates, Esters, etc.
3
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Search results for
"EMA EPAR|DISEASES|MUSCULOSKELETAL DISEASES|RHEUMATIC DISEASES|ARTHRITIS, RHEUMATOID"
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TOCILIZUMAB
MORE DETAILS
I031V2H011
Subunit
1
(448) Similarity Search
Subunit
2
(448) Similarity Search
Subunit
3
(214) Similarity Search
Subunit
4
(214) Similarity Search
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Subunit
1
(448) Similarity Search
Subunit
2
(448) Similarity Search
Subunit
3
(214) Similarity Search
Subunit
4
(214) Similarity Search
Status:
US Approved Rx (2013)
First approved in 2010
Class:
PROTEIN
CANAKINUMAB
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37CQ2C7X93
Subunit
1
(448) Similarity Search
Subunit
2
(448) Similarity Search
Subunit
3
(214) Similarity Search
Subunit
4
(214) Similarity Search
Export Data
Sequence Search
Subunit
1
(448) Similarity Search
Subunit
2
(448) Similarity Search
Subunit
3
(214) Similarity Search
Subunit
4
(214) Similarity Search
Status:
US Approved Rx (2009)
First approved in 2009
Class:
PROTEIN
GOLIMUMAB
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91X1KLU43E
Subunit
1
(456) Similarity Search
Subunit
2
(456) Similarity Search
Subunit
3
(215) Similarity Search
Subunit
4
(215) Similarity Search
Export Data
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Subunit
1
(456) Similarity Search
Subunit
2
(456) Similarity Search
Subunit
3
(215) Similarity Search
Subunit
4
(215) Similarity Search
Status:
US Approved Rx (2013)
First approved in 2009
Class:
PROTEIN
CERTOLIZUMAB PEGOL
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UMD07X179E
Subunit
1
(229) Similarity Search
Subunit
2
(214) Similarity Search
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Subunit
1
(229) Similarity Search
Subunit
2
(214) Similarity Search
Status:
US Approved Rx (2008)
First approved in 2008
Class:
PROTEIN
ABATACEPT
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7D0YB67S97
Subunit
1
(383) Similarity Search
Subunit
2
(383) Similarity Search
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Subunit
1
(383) Similarity Search
Subunit
2
(383) Similarity Search
Status:
US Approved Rx (2005)
First approved in 2005
Class:
PROTEIN
ADALIMUMAB
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FYS6T7F842
Subunit
1
(451) Similarity Search
Subunit
2
(451) Similarity Search
Subunit
3
(214) Similarity Search
Subunit
4
(214) Similarity Search
Export Data
Sequence Search
Subunit
1
(451) Similarity Search
Subunit
2
(451) Similarity Search
Subunit
3
(214) Similarity Search
Subunit
4
(214) Similarity Search
Status:
US Approved Rx (2021)
First approved in 2002
Class:
PROTEIN
ANAKINRA
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9013DUQ28K
Subunit
1
(153) Similarity Search
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Subunit
1
(153) Similarity Search
Status:
US Approved Rx (2001)
First approved in 2001
Class:
PROTEIN
INFLIXIMAB
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B72HH48FLU
Subunit
1
(450) Similarity Search
Subunit
2
(450) Similarity Search
Subunit
3
(214) Similarity Search
Subunit
4
(214) Similarity Search
Export Data
Sequence Search
Subunit
1
(450) Similarity Search
Subunit
2
(450) Similarity Search
Subunit
3
(214) Similarity Search
Subunit
4
(214) Similarity Search
Status:
US Approved Rx (2019)
First approved in 1998
Class:
PROTEIN
ETANERCEPT
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OP401G7OJC
Subunit
1
(467) Similarity Search
Subunit
2
(467) Similarity Search
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Subunit
1
(467) Similarity Search
Subunit
2
(467) Similarity Search
Status:
US Approved Rx (1998)
First approved in 1998
Class:
PROTEIN
RITUXIMAB
MORE DETAILS
4F4X42SYQ6
Subunit
1
(451) Similarity Search
Subunit
2
(451) Similarity Search
Subunit
3
(213) Similarity Search
Subunit
4
(213) Similarity Search
Export Data
Sequence Search
Subunit
1
(451) Similarity Search
Subunit
2
(451) Similarity Search
Subunit
3
(213) Similarity Search
Subunit
4
(213) Similarity Search
Status:
US Approved Rx (2020)
First approved in 1997
Class:
PROTEIN
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