U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 951 - 960 of 10251 results

Status:
Investigational
Source:
INN:acridorex
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Acridorex (BS 7573a) is an anorectic agent.
Status:
Investigational
Source:
NCT02342249: Phase 2 Interventional Completed Influenza A
(2014)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)


JNJ-872 is an inhibitor of influenza virus replication that offers a potential for the treatment of pandemic and seasonal influenza.
Status:
Investigational
Source:
NCT02764385: Not Applicable Interventional Completed Smoking
(2016)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
INN:clonitazene [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Clonitazene is a synthetic opioid analgesic, structurally related to etonitazene. In the USA clonitazene is a schedule I narcotic controlled substance.
Status:
Investigational
Source:
NCT01270438: Phase 2 Interventional Withdrawn Adenocarcinoma of the Colon
(2010)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



RO4929097 (R-4733) is a small-molecule inhibitor of gamma-secretase (γ-secretase) with high oral bioavailability leading to the blockade of Notch signaling in tumor cells. This compound was co-developed by Roche and National Cancer Institute (NCI). RO4929097 had been in phase II clinical trials for the treatment of melanoma, colorectal cancer, and pancreatic cancer. However, these researches has been discontinued. Combination of RO4929097 and bevacizumab was well tolerated in phase I of clinical trial and can be considered in patients with recurrent malignant glioma.
Status:
Investigational
Source:
NCT00028873: Phase 2 Interventional Completed Breast Cancer
(2001)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

LANIQUIDAR is a P-glycoprotein inhibitor. It was used in trials studying the treatment of breast cancer.
Status:
Investigational
Source:
INN:mipitroban
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Mipitroban (previously known as UP 11677), a thromboxane A2 receptor antagonist that was investigated to treat thrombosis. However, further studies were apparently discontinued.
Status:
Investigational
Source:
INN:hydroxypethidine
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Hydroxypethidine, an opioid analgesic is an opioid receptor agonist. Hydroxypethidine is under the control of narcotic drugs according to US Single Convention 1961.
Status:
Investigational
Source:
USAN:Acetiamine
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Acetiamine (syn. thianeurone or diacetamine) is a thiamine derivative which is rarely used in pharmaceuticals. It is lipid-soluble. It has been studied for the treatment of rheumatic diseases.
Status:
Investigational
Source:
INN:acetorphine
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Acetorphine is a synthetic narcotic analgesic. Acetorphine was reported to have uses in veterinary medicine with pronounced advantages in the immobilization of the giraffe in which toxic effects were reduced as compared to the effects of etorphine. In July 1966, the Director-General of the World Health Organization informed the Secretary-General that WHO had arrived at the conclusion that etorphine and acetorphine should be included in Schedule I of the Convention, since they could give rise to similar abuse, and produce similar ill effects as the substances already listed therein. Acetorphine is a Schedule I controlled substance in the United States.