Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C11H9N3 |
| Molecular Weight | 183.2093 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=NC2=C(C=C1)C3=C(N2)C=CC=C3
InChI
InChIKey=FJTNLJLPLJDTRM-UHFFFAOYSA-N
InChI=1S/C11H9N3/c12-10-6-5-8-7-3-1-2-4-9(7)13-11(8)14-10/h1-6H,(H3,12,13,14)
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Effect of Cytochrome P450 Reductase Deficiency on 2-Amino-9H-pyrido[2,3-b]indole Metabolism and DNA Adduct Formation in Liver and Extrahepatic Tissues of Mice. | 2015-12-21 |
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| DNA adducts of the tobacco carcinogens 2-amino-9H-pyrido[2,3-b]indole and 4-aminobiphenyl are formed at environmental exposure levels and persist in human hepatocytes. | 2013-09-16 |
|
| Naturally occurring food toxins. | 2010-09 |
|
| Identification of carcinogen DNA adducts in human saliva by linear quadrupole ion trap/multistage tandem mass spectrometry. | 2010-07-19 |
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| Simultaneous determination of six non-polar heterocyclic amines in meat samples by supercritical fluid extraction-capillary electrophoresis under fluorimetric detection. | 2010-07 |
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| Suitability of ionic liquids as mobile-phase additives in HPLC with fluorescence and UV detection for the determination of heterocyclic aromatic amines. | 2010-02 |
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| Biomonitoring of carcinogenic heterocyclic aromatic amines in hair: a validation study. | 2009-08 |
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| The impact of NAT2 acetylator genotype on mutagenesis and DNA adducts from 2-amino-9H-pyrido[2,3-b]indole. | 2009-04 |
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| Effect of 2-amino-9H-pyrido[2,3-b]indole (AalphaC), a carcinogenic heterocyclic amine present in food, on atherosclerotic plaque development in apoE deficient mice. | 2009-03-10 |
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| Ethanol Does Not Promote MeIQx-initiated Rat Colon Carcinogenesis Based on Evidence from Analysis of a Colon Cancer Surrogate Marker. | 2009-03 |
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| Prospective study of dietary patterns and colorectal cancer among Singapore Chinese. | 2008-11-04 |
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| Binding of heterocyclic aromatic amines by lactic acid bacteria: results of a comprehensive screening trial. | 2008-03 |
|
| Model studies of lignified fiber fermentation by human fecal microbiota and its impact on heterocyclic aromatic amine adsorption. | 2007-11-01 |
|
| Tobacco smoking and urinary levels of 2-amino-9H-pyrido[2,3-b]indole in men of Shanghai, China. | 2007-08 |
|
| Solid-matrix luminescence of heterocyclic aromatic amines in several new sugar-glass systems. | 2007-04-15 |
|
| Metabolites of the carcinogen 2-amino-alpha-carboline formed in male Sprague-Dawley rats in vivo and in rat hepatocyte and human HepG2 cell incubates. | 2007-03 |
|
| Differential effects of heterocyclic amines on poly(ADP-ribose) polymerase-1 and mono-ADP-ribosyltransferase A. | 2006-09 |
|
| Influence of lignification and feruloylation of maize cell walls on the adsorption of heterocyclic aromatic amines. | 2006-03-08 |
|
| Investigation of the separation of heterocyclic aromatic amines by reversed phase ion-pair liquid chromatography coupled with tandem mass spectrometry: the role of ion pair reagents on LC-MS/MS sensitivity. | 2005-10-25 |
|
| Quantitation of carcinogenic heterocyclic aromatic amines and detection of novel heterocyclic aromatic amines in cooked meats and grill scrapings by HPLC/ESI-MS. | 2005-04-20 |
|
| DNA adduct formation of 14 heterocyclic aromatic amines in mouse tissue after oral administration and characterization of the DNA adduct formed by 2-amino-9H-pyrido[2,3-b]indole (AalphaC), analysed by 32P_HPLC. | 2005-03-15 |
|
| Two food-borne heterocyclic amines: metabolism and DNA adduct formation of amino-alpha-carbolines. | 2005-03 |
|
| Analysis of alpha- and beta-carbolines in mainstream smoke of reference cigarettes by gas chromatography-mass spectrometry. | 2004-08-13 |
|
| Rapid biomonitoring of heterocyclic aromatic amines in human urine by tandem solvent solid phase extraction liquid chromatography electrospray ionization mass spectrometry. | 2004-08 |
|
| Syntheses of DNA adducts of two heterocyclic amines, 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAalphaC) and 2-amino-9H-pyrido[2,3-b]indole (AalphaC) and identification of DNA adducts in organs from rats dosed with MeAalphaC. | 2004-08 |
|
| Relationship between content and activity of cytochrome P450 and induction of heterocyclic amine DNA adducts in human liver samples in vivo and in vitro. | 2004-06 |
|
| Excretion of metabolites in urine and faeces from rats dosed with the heterocyclic amine, 2-amino-9H-pyrido[2,3-b]indole (AalphaC). | 2004-06 |
|
| Investigation of the genotoxic effects of 2-amino-9H-pyrido[2,3-b]indole in different organs of rodents and in human derived cells. | 2004-03-25 |
|
| Prevention of heterocyclic amine-induced DNA damage in colon and liver of rats by different lactobacillus strains. | 2003-12 |
|
| Impact of five cytochrome p450 enzymes on the metabolism of two heterocyclic aromatic amines, 2-amino-9H-pyrido[2,3-b]indole (AalphaC) and 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAalphaC). | 2003-05 |
|
| Probiotic mixture decreases DNA adduct formation in colonic epithelium induced by the food mutagen 2-amino-9H-pyrido[2,3-b]indole in a human-flora associated mouse model. | 2003-04 |
|
| The food mutagen 2-amino-9H-pyrido[2,3-b]indole (AalphaC) but not its methylated form (MeAalphaC) increases intestinal tumorigenesis in neonatally exposed multiple intestinal neoplasia mice. | 2002-08 |
|
| Effects of soy sauce and sugar on the formation of heterocyclic amines in marinated foods. | 2002-07 |
|
| Mutagenic and carcinogenic heterocyclic amines as affected by muscle types/skin and cooking in pan-roasted mackerel. | 2002-03-25 |
|
| In vitro metabolism of two heterocyclic amines, 2-amino-9H-pyrido[2,3-b]indole (A(alpha)C) and 2-amino-3-methyl-9H-pyridol2,3-b]indole (MeA(alpha)C) in human and rat hepatic microsomes. | 2002-03 |
|
| Antimutagenicity of Murdannia loriformis in the Salmonella mutation assay and its inhibitory effects on azoxymethane-induced DNA methylation and aberrant crypt focus formation in male F344 rats. | 2002-02 |
|
| Activation of amino-alpha-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes. | 1991-10-01 |
|
| Carcinogenicity in mice and rats of heterocyclic amines in cooked foods. | 1986-08 |
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P0GZ1ICS6X
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26148-68-5
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62805
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C017822
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7086
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SUBSTANCE RECORD
