U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 861 - 870 of 3134 results

Status:
Investigational
Source:
INN:bromociclen [INN]
Source URL:

Class (Stereo):
CHEMICAL (EPIMERIC)


Bromociclen (5-(Bromomethyl)-1,2,3,4,7,7-hexachlorobicyclo[2.2.1]hept-2-ene; 5-(Bromomethyl)-1,2,3,4,7,7-hexachloro-2-norbornene) is a halogenated bicyclic insecticide. Bromociclen is used for the control of stored-product insects as well as against ecto-parasites.
Status:
Investigational
Source:
JAN:PROPETAMPHOS [JAN]
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Status:
Investigational
Source:
INN:etiproston
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Etiproston is a synthetic analog of prostaglandin F2α. Etiproston induces luteal regression. Etiproston is used in veterinary.
Status:
Investigational
Source:
INN:butafosfan
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Butafosfan is a phosphororganic supplement that is given, most commonly with cyanocobalamin, to cattle, swine, horses, and poultry for the prevention or treatment of phosphorus deficiencies. Butafosfan also plays a vital role in hepatic carbohydrate metabolism. In addition, butafosfan has been regarded as an antistress agent in combination with vitamin B12. Studies with butafosfan in different animals have shown that it improved general health status by stimulating feed intake, immune system, and digestive function. Butafosfan has been reported for the treatment of metabolic disorders caused by stress or nutrition problems in various species.
Status:
Investigational
Source:
INN:denaverine
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Denaverine is a benzilacid derivative. It is a phenobarbital-type microsomal enzyme inducer. Denaverine has a relaxing effect on the prepartum uterus and provides an increased flexibility of the soft birth canal. In addition, it has a surface anaestetic effect and an anticonvulsive effect as well as a slightly tranquilizing and antipyretic effect. In veterinary medicine denaverine hydrochloride is used to regulate myometrial contractions during parturition. It is a regularly used substance in obstetrics in veterinary medicine in many European countries.
Status:
Investigational
Source:
INN:aglepristone
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Aglepristone (RU 46534) is a competitive progesterone antagonist; it binds to progesterone receptors (PRs) without inducing the molecular cascade associated with progesterone. Its affinity to PRs is higher than progesterone (3.12, 3.8, and 9.26 times greater in the bitch, doe rabbit,and queen, respectively). Aglepristone can therefore beused in various progesterone-dependent physiological orpathologic conditions, with the aim of blocking the action of progesterone. Aglepristone has proven to be an effective and safe means of inducing pregnancy termination or parturition in a large number of domestic species. In domestic species, aglepristone is routinely used for the treatment of pyometra and feline mammary fibroadenomatous hyperplasia, both of which are progesterone dependent. Aglepristone is marketed under the brand name Alizin used as the treatment option for unwanted mating and pregnancy in dogs
Status:
Investigational
Source:
Parasitol Res. Oct 2010;107(5):1205-11.: Not Applicable Veterinary clinical trial Completed Sheep Diseases
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Nitroxinil is an anthelmintic drug mainly used for the control of liver fluke in sheep and cattle. Nitroxinil is active against the liver fluke the Fasciola hepatica and to a lesser extent against thread worms in the gastrointestinal tract. The efficacy of nitroxinil administered once by subcutaneous injection at a dosage regimen of 20 mg/kg live mass was evaluated against natural infestations of parafilaria bovicola in cattle. Trial animals were slaughtered 14 weeks after treatment. Treatment reduced the number of bleeding points by 97,8%, eosinophil-positive carcass lesions by 85,7% and eosinophil-positive lesion area by 92,8%, compared with controls.
Status:
Investigational
Source:
INN:benethamine penicillin [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Benethamine penicillin is a medium-long-acting insoluble penicillin salt. After a single injection, this salt acts and bacteriostatic level of penicillin is maintained in the blood for three to six days.
Closantel is a synthetic anti parasitic agent which is highly effective against adults and larvae (6 to weeks old) of liver flukes (Fasciola hepatica), and against several important gastrointestinal roundworms (e.g. Bunostomum, Haemonchus, Oesophagostomum, Ostertagia - Teladorsagia, Strongyloides, Trichostrongylus), as well as against screwworms (maggots of Cochliomyia spp and Chrysomya spp), sheep nasal bots (Oestrus ovis), and sheep keds (Melophagus ovinus). The molecular mode of action closantel is not completely elucidated, but closantel decouples the mitochondrial oxidative phosphorylation, which leads to the inhibition of ATP synthesis, this seems to occur through suppression of the activity of succinate dehydrogenase and fumarate reductase, two enzymes involved in this process. Finally this all cause the death of the parasite. Recently it has been discovered that closantel also inhibits chitinase in Onchocerca volvulus, a filarial nematode causing river blindness in humans. Chitinase is an enzyme involved in larval molting. Its inhibition interrupts their development to adult worms. This drug possesses some side effects: hyper acute anaphylactic reactions in cattle; hypersensitivity reactions; overdoses can cause reduced visibility or blindness, anorexia, lack of coordination and general weakness.
Status:
Investigational
Source:
INN:osaterone
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)