Stereochemistry | ACHIRAL |
Molecular Formula | C7H3IN2O3 |
Molecular Weight | 290.0148 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC1=C(I)C=C(C=C1[N+]([O-])=O)C#N
InChI
InChIKey=SGKGVABHDAQAJO-UHFFFAOYSA-N
InChI=1S/C7H3IN2O3/c8-5-1-4(3-9)2-6(7(5)11)10(12)13/h1-2,11H
Molecular Formula | C7H3IN2O3 |
Molecular Weight | 290.0148 |
Charge | 0 |
Count |
MOL RATIO
1 MOL RATIO (average) |
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Nitroxinil is an anthelmintic drug mainly used for the control of liver fluke in sheep and cattle. Nitroxinil is active against the liver fluke the Fasciola hepatica and to a lesser extent against thread worms in the gastrointestinal tract. The efficacy of nitroxinil administered once by subcutaneous injection at a dosage regimen of 20 mg/kg live mass was evaluated against natural infestations of parafilaria bovicola in cattle. Trial animals were slaughtered 14 weeks after treatment. Treatment reduced the number of bleeding points by 97,8%, eosinophil-positive carcass lesions by 85,7% and eosinophil-positive lesion area by 92,8%, compared with controls.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
PubMed
Patents
Sample Use Guides
Nitroxinil injected subcutaneously at 10 mg/kg live mass achieved Class A efficacy when evaluated by the non parametric method against adult Fasciola gigantica. Haemonchus placei, Bonustomum phlebotomum and Oesophagostomum radiatum in cattle. The compound was not effective against adult Cooperia spp. at the same dosage.
Route of Administration:
Other
Nitroxinil at 10(-3) M produced 60% inhibition in F. buski homogenates yet had little effect at this concentration on preparations from the other species. Rapid death of Fasicola gigantica and P. explanatum resulted in vitro when 10(-3) M nitroxinil was added to the incubation medium.