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Details

Stereochemistry ACHIRAL
Molecular Formula C7H3IN2O3
Molecular Weight 290.0148
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NITROXINIL

SMILES

OC1=C(I)C=C(C=C1[N+]([O-])=O)C#N

InChI

InChIKey=SGKGVABHDAQAJO-UHFFFAOYSA-N
InChI=1S/C7H3IN2O3/c8-5-1-4(3-9)2-6(7(5)11)10(12)13/h1-2,11H

HIDE SMILES / InChI

Molecular Formula C7H3IN2O3
Molecular Weight 290.0148
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Nitroxinil is an anthelmintic drug mainly used for the control of liver fluke in sheep and cattle. Nitroxinil is active against the liver fluke the Fasciola hepatica and to a lesser extent against thread worms in the gastrointestinal tract. The efficacy of nitroxinil administered once by subcutaneous injection at a dosage regimen of 20 mg/kg live mass was evaluated against natural infestations of parafilaria bovicola in cattle. Trial animals were slaughtered 14 weeks after treatment. Treatment reduced the number of bleeding points by 97,8%, eosinophil-positive carcass lesions by 85,7% and eosinophil-positive lesion area by 92,8%, compared with controls.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
Nitroxinil injected subcutaneously at 10 mg/kg live mass achieved Class A efficacy when evaluated by the non parametric method against adult Fasciola gigantica. Haemonchus placei, Bonustomum phlebotomum and Oesophagostomum radiatum in cattle. The compound was not effective against adult Cooperia spp. at the same dosage.
Route of Administration: Other
In Vitro Use Guide
Nitroxinil at 10(-3) M produced 60% inhibition in F. buski homogenates yet had little effect at this concentration on preparations from the other species. Rapid death of Fasicola gigantica and P. explanatum resulted in vitro when 10(-3) M nitroxinil was added to the incubation medium.
Substance Class Chemical
Record UNII
9L0EXQ7125
Record Status Validated (UNII)
Record Version