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Restrict the search for
alpha-tocopherol
to a specific field?
Status:
Investigational
Source:
NCT02360345: Phase 1 Interventional Completed Solid Tumours
(2013)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Investigational
Source:
INN:bifepramide [INN]
Source URL:
Class (Stereo):
CHEMICAL (UNKNOWN)
Bifepramide, (+)- belong to the class of parasympatholytic agents that reduce the activity of the parasympathetic nervous system.
Status:
Investigational
Source:
INN:asalhydromorphone [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Investigational
Source:
NCT02471196: Phase 2 Interventional Completed Alzheimer's Disease
(2015)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Juvantia Pharma and Orion developed ORM-12741, also known as ORM-10921, a novel selective antagonist of alpha-2C adrenoceptors for the treatment of depression and Alzheimer's disease. ORM-12741 participated in phase II clinical trial where was evaluated the safety and efficacy of the drug in patients with Alzheimer's disease. In spite of the successfully completed phase II, further study of the drug for this disease was discontinued. In addition, ORM-12741 participated in clinical trial phase II to prove the concept that this drug could prevent blood vessel spasms for Raynaud's phenomenon. Raynaud's phenomenon is a disorder of the digital blood vessels resulting in episodic impairment of blood flow. However, this study was terminated because of the recommendation by study Data and Safety Monitoring Committee to the sponsor following the interim analysis of 8 subjects.
Status:
Investigational
Source:
NCT02557321: Phase 1/Phase 2 Interventional Active, not recruiting Melanoma
(2015)
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Status:
Investigational
Source:
NCT01725139: Phase 1 Interventional Completed Idiopathic Pulmonary Fibrosis
(2013)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Omipalisib, also known as GSK2126458, is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity. Omipalisib (GSK2126458, GSK458) is a highly selective and potent inhibitor of p110α/β/δ/γ, mTORC1/2 with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM in cell-free assays, respectively. It is also a low picomolar inhibitor of the common activating
mutants of p110a (E542K, E545K, and H1047R) found in
human cancer. Omipalisib (GSK2126458) binds to and inhibits PI3K in the PI3K/mTOR signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability and inducing apoptotic cell death. Bax is a member of the proapoptotic Bcl2 family of proteins. PI3K, often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival. GlaxoSmithKline (GSK) is developing omipalisib, a phosphoinositide 3-kinase/mammalian target of rapamycin (PI3K/mTOR) inhibitor as well as mTOR complex 1 and 2 inhibitor, for the potential oral treatment of cancer and idiopathic pulmonary fibrosis.
Status:
Investigational
Source:
NCT02677207: Phase 2 Interventional Completed Depression
(2016)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
JNJ-39393406 is a positive allosteric alpha-7 nicotinic acetylcholine receptor modulator. It was under development for the treatment of smoking cessation, schizophrenia, Alzheimer's disease, but development for these indications was discontinued.
Status:
Investigational
Source:
NCT00862888: Phase 2 Interventional Completed Erectile Dysfunction
(2007)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
PF-00446687 is the highly selective, brain-penetrant, melanocortin 4 receptor (MC4R) agonist. PF-00446687 induced partner preferences formation in females prairie voles after a 6-h cohabitation without mating. PF-00446687 had been in phase I clinical trial for the treatment of sexual function disorders.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Investigational
Source:
NCT00942656: Not Applicable Interventional Completed Cardiovascular Disease
(2009)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Vaccenic acid (VA) (t11 octadecenoic acid) is a positional and geometric isomer of oleic acid (c9-octadecenoic acid), and is the predominant trans monoene in ruminant fats (50%–80% of total trans content). Dietary VA can be desaturated to cis-9,trans-11 conjugated
linoleic acid (c9,t11-CLA) in ruminants, rodents,
and humans. Hydrogenated plant oils are another source of VA in
the diet, and it has been recently estimated that this source
may contribute to about 13%–17% of total VA intake. In contrast to suggestions from the epidemiological studies,
the majority of studies using cancer cell lines (Awad et
al. 1995; Miller et al. 2003) or rodent tumors (Banni et al.
2001; Corl et al. 2003; Ip et al. 1999; Sauer et al. 2004)
have demonstrated that VA reduces cell growth and (or) tumor
metabolism. Animal and in vitro studies suggest that
the anti-cancer properties of VA are due, in part, to the in
vivo conversion of VA to c9,t11-CLA. However, several additional
mechanisms for the anti-cancer effects of VA have
been proposed, including changes in phosphatidylinositol
hydrolysis, reduced proliferation, increased apoptosis, and inhibition
of fatty acid uptake. In conclusion,
although the epidemiological evidence of VA intake
and cancer risk suggests a positive relationship, this is not
supported by the few animal studies that have been performed. The majority of the studies suggest that any health benefit
of VA may be conferred by in vivo mammalian conversion
of VA to c9,t11-CLA. VA acts as a partial agonist to both peroxisome proliferator-activated receptors (PPAR)-α and PPAR-γ in vitro, with similar affinity compared to commonly known PPAR agonists. Hypolipidemic and
antihypertrophic bioactivity of VA is potentially mediated
via PPAR-/-dependent pathways.
