PF-00446687

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C28H36F2N2O2
Molecular Weight	470.5944
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@H]1CN(C[C@@H](C)[C@]1(O)C2=CC=CC=C2)C(=O)[C@@H]3CN(C[C@H]3C4=CC=C(F)C=C4F)C(C)(C)C

InChI

InChIKey=WHPJOAUPIZDJNX-AGGGUQDCSA-N

InChI=1S/C28H36F2N2O2/c1-18-14-31(15-19(2)28(18,34)20-9-7-6-8-10-20)26(33)24-17-32(27(3,4)5)16-23(24)22-12-11-21(29)13-25(22)30/h6-13,18-19,23-24,34H,14-17H2,1-5H3/t18-,19+,23-,24+,28-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C28H36F2N2O2
Molecular Weight	470.5944
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25652247 | https://adisinsight.springer.com/drugs/800025591 | DOI: 10.1016/B978-0-12-803506-1.00045-0

PF-00446687 is the highly selective, brain-penetrant, melanocortin 4 receptor (MC4R) agonist. PF-00446687 induced partner preferences formation in females prairie voles after a 6-h cohabitation without mating. PF-00446687 had been in phase I clinical trial for the treatment of sexual function disorders.

CNS Activity

Originator

Approval Year

PubMed

Title	Date	PubMed
Melanocortin Receptor Agonists Facilitate Oxytocin-Dependent Partner Preference Formation in the Prairie Vole.	2015-07	25652247
Neonatal melanocortin receptor agonist treatment reduces play fighting and promotes adult attachment in prairie voles in a sex-dependent manner.	2014-10	24923239
Evaluation of the clearance of a sublingual buprenorphine spray in the beagle dog using gamma scintigraphy.	2008-04	17763831

Patents

Sample Use Guides

In Vivo Use Guide

1 or 10 mg/kg

Route of Administration: Intraperitoneal

Substance Class	Chemical Created by `admin` on `Mon Mar 31 23:18:08 GMT 2025` Edited by `admin` on `Mon Mar 31 23:18:08 GMT 2025`
Record UNII	63P236Z73I
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PF-00446687

Common Name

English

(-)-PF-00446687

Preferred Name

English

METHANONE, ((3S,4R)-4-(2,4-DIFLUOROPHENYL)-1-(1,1-DIMETHYLETHYL)-3-PYRROLIDINYL)((3R,5S)-4-HYDROXY-3,5-DIMETHYL-4-PHENYL-1-PIPERIDINYL)-

Systematic Name

English

4-PIPERIDINOL, 1-(((3S,4R)-4-(2,4-DIFLUOROPHENYL)-1-(1,1-DIMETHYLETHYL)-3-PYRROLIDINYL)CARBONYL)-3,5-DIMETHYL-4-PHENYL-, (3.ALPHA.,4.ALPHA.,5.ALPHA.)-

Systematic Name

English

Code System Code Type Description

FDA UNII

63P236Z73I