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Restrict the search for
vitamin a
to a specific field?
Class (Stereo):
CHEMICAL (RACEMIC)
Tifluadom is an opioid benzodiazepine with potent analgesic activity. Studies using antagonists for κ-, δ-, and μ-opiate receptors in guinea pig myenteric plexus-longitudinal muscle preparation and mouse and rabbit vasa deferentia showed that Tifluadom is an opioid analgesic with a preference for opiate κ-receptors. In rat brain homogenates, tifluadom displaced kappa-antagonist naloxone from its binding sites with an IC50 of 12nM but had no effect on flunitrazepam binding. Tifluadom produced a dose-related diuresis in normally hydrated rats and the diuretic effect was antagonized by naloxone and blocked by morphine administration.
Class (Stereo):
CHEMICAL (UNKNOWN)
Tiflorex (also known as (+)-Flutiorex) is a phenylalkylamine derivative patented by Synthelabo S. A. as an anorectic agent. Tiflorex acts as a central nervous system stimulant form amphetamine class with little effect on pulse rate, sleep, or mood. In preclinical models, Tiflorex provoked a dose-dependent reduction in the consumption of the protein-rich diet and a reduction in the consumption of the protein-poor diet.
Class (Stereo):
CHEMICAL (RACEMIC)
Protheobromine is a derivative of the xanthine alkaloid theobromine with diuretic and vasodilating activity.
Class (Stereo):
CHEMICAL (MIXED)
Iotasulis a triiodoaminoisophthalic acid derivative patented by Schering A.-G. as a water-soluble contrast medium. Iotasul is very suitable for subepidermal infusion (indirect lymphography) for the demonstration of small (initial) dermal lymphatics in the macro-range (precollectors). By this method, normal lymph vessels can be demonstrated in the healthy skin of hands and feet which are so fine that they cannot be punctured for direct lymphography.
Class (Stereo):
CHEMICAL (ACHIRAL)
Sulicrinat (also known as HOE 428) is a sulfamoylbenzophenone derivative patented by Hoechst A.-G. as a loop diuretic.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Taprizosin (also known as UK-338,003) is an alpha1A-adrenoceptor antagonist that was developed for the treatment of benign prostatic hyperplasia. However, this compound possesses poor oral absorption.
Status:
Investigational
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Status:
Investigational
Source:
NCT00080132: Phase 2 Interventional Terminated Hypertriglyceridemia
(2004)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Implitapide is a microsomal triglyceride transfer protein (MTP) inhibitor with antihyperlipidemic activity. Microsomal triglyceride transfer protein (MTP) is essential for the synthesis of both chylomicron in the intestine and very low-density lipoprotein in the liver. In an animal model, inhibition of MTP by implitapide reduced both total cholesterol and triglyceride levels and suppressed progression of atherosclerotic lesions in apolipoprotein E knockout mice fed a Western-type diet.
Status:
Investigational
Source:
NCT02511197: Early Phase 1 Interventional Unknown status Pulmonary Fibrosis, Unspecified
(2015)
Source URL:
Class (Stereo):
CHEMICAL (EPIMERIC)
Status:
Investigational
Class (Stereo):
CHEMICAL (RACEMIC)
Carfimate is chemically known as α-Ethynylbenzenemethanol carbamate having sedative, hypnotic activities.
