CALENDULOSIDE H is the derivative of oleanolic acid present in a wide variety of Caltha plants. CALENDULOSIDE H exhibited marked antiinflammatory activity in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice.

The triterpene chikusetsusaponin IVa, also called, as Chikusetsu saponin Iva and CALENDULOSIDE F, was isolated from the fruit of Ilex paraguariensis. Using animal model it was shown that this compound could be a promising novel therapeutic agent for diabetic cardiomyopathy, due to its cardio protection; this effect can be reached by activation of the SIRT1/ERK1/2/Homer1a pathway. In addition was demonstrated, that chikusetsusaponin IVa exerts antithrombotic effects, including minor hemorrhagic events, by inhibition of thrombin in a competitive manner.