U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 731 - 740 of 18087 results

Status:
Investigational
Source:
INN:carbenzide
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Carbenzide is hydrazine derivative with the high antidepressant activity and low toxicity patented by pharmaceutical company Warner-Lambert Pharmaceutical Co. Carbenzide acts via monoamine oxidase (MAO) inhibition and increase the level of brain serotonin.
Status:
Investigational
Source:
NCT04719273: Phase 2 Interventional Active, not recruiting Refractory Endometrial Adenocarcinoma
(2021)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Onapristone is a type I progesterone receptor (PR) antagonist that prevents PR- mediated DNA transcription and was studied as an antitumor agent. This drug possessed activity in breast cancer and is participating in phase II clinical trials to test any good and bad effect for the treatment of endometrial cancer, ovarian cancer, peritoneal cancer, and prostate cancer.
Status:
Investigational
Source:
INN:bidisomide
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Bidisomide (previously known as SC 40230) was developed as a sodium channel antagonist with class I antiarrhythmic properties. Bidisomide participated in clinical trials for patients with arrhythmia. However, the development was discontinued due to a lack of demonstrable efficacy.
Status:
Investigational
Source:
JAN:HYDRAMETHYLNON [JAN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
INN:efepristin
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Efepristin (RPR 106972) is an oral streptogramin consisting of two synergistic components RPR 112808 (pristinamycin IB) and RPR 106950 (pristinamycin IIB). It demonstrated activity against Gram-positive microorganisms in vitro and in vivo, including those with multi-drug resistance. The streptogramins inhibit bacterial growth by disrupting the translation of mRNA into protein.
Status:
Investigational
Source:
INN:levoprotiline
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Oxaprotiline (also known as hydroxymaprotiline) is a norepinephrine reuptake inhibitor and blocked the histamine H1 receptor. Oxaprotiline was studied in the treatment of hospitalized depressive patients. However, this drug has never been marketed.
Status:
Investigational
Source:
NCT03141073: Phase 3 Interventional Completed Diabetes Mellitus, Type 2
(2017)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
INN:timobesone
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Timobesone is a topical corticosteroid and thiol ester derivative with anti-inflammatory activity.
Status:
Investigational
Source:
INN:descinolone
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
INN:trimoxamine [INN]
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Trimoxamine hydrochloride is an antihypertensive agent.