Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C29H39NO3 |
| Molecular Weight | 449.6249 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CC[C@](O)(CCCO)[C@]1(C)C[C@H](C3=CC=C(C=C3)N(C)C)C4=C5CCC(=O)C=C5CC[C@@]24[H]
InChI
InChIKey=IEXUMDBQLIVNHZ-YOUGDJEHSA-N
InChI=1S/C29H39NO3/c1-28-18-25(19-5-8-21(9-6-19)30(2)3)27-23-12-10-22(32)17-20(23)7-11-24(27)26(28)13-15-29(28,33)14-4-16-31/h5-6,8-9,17,24-26,31,33H,4,7,10-16,18H2,1-3H3/t24-,25+,26-,28+,29+/m0/s1
Onapristone is a type I progesterone receptor (PR) antagonist that prevents PR- mediated DNA transcription and was studied as an antitumor agent. This drug possessed activity in breast cancer and is participating in phase II clinical trials to test any good and bad effect for the treatment of endometrial cancer, ovarian cancer, peritoneal cancer, and prostate cancer.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Synthesis and biological activity of novel nonsteroidal progesterone receptor antagonists based on cyclocymopol monomethyl ether. | 1996 Apr 26 |
|
| Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore. | 2003 Jun 16 |
|
| Characterization of a critical region in the hormone binding domain of sperm progesterone receptor. | 2005 Apr |
|
| Ligand-selective targeting of the glucocorticoid receptor to nuclear subdomains is associated with decreased receptor mobility. | 2005 Jun |
|
| Effects of progesterone on iNOS, COX-2, and collagen expression in the cervix. | 2006 Jun |
|
| Progesterone-induced sphingosine kinase-1 expression in the rat uterus during pregnancy and signaling consequences. | 2007 Apr |
|
| Regulation of homeobox A10 expression in the primate endometrium by progesterone and embryonic stimuli. | 2007 Sep |
|
| Anti-apoptotic roles of prostaglandin E2 and F2alpha in bovine luteal steroidogenic cells. | 2008 Aug |
|
| Luteoprotective roles of luteinizing hormone are mediated by not only progesterone production but also glucocorticoid conversion in bovine corpus luteum. | 2013 Mar |
Patents
| Name | Type | Language | ||
|---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
96346-61-1
Created by
admin on Fri Dec 15 18:45:07 GMT 2023 , Edited by admin on Fri Dec 15 18:45:07 GMT 2023
|
PRIMARY | |||
|
CHEMBL1908373
Created by
admin on Fri Dec 15 18:45:07 GMT 2023 , Edited by admin on Fri Dec 15 18:45:07 GMT 2023
|
PRIMARY | |||
|
SUB09444MIG
Created by
admin on Fri Dec 15 18:45:07 GMT 2023 , Edited by admin on Fri Dec 15 18:45:07 GMT 2023
|
PRIMARY | |||
|
m8212
Created by
admin on Fri Dec 15 18:45:07 GMT 2023 , Edited by admin on Fri Dec 15 18:45:07 GMT 2023
|
PRIMARY | Merck Index | ||
|
5311505
Created by
admin on Fri Dec 15 18:45:07 GMT 2023 , Edited by admin on Fri Dec 15 18:45:07 GMT 2023
|
PRIMARY | |||
|
Onapristone
Created by
admin on Fri Dec 15 18:45:07 GMT 2023 , Edited by admin on Fri Dec 15 18:45:07 GMT 2023
|
PRIMARY | |||
|
DTXSID90242210
Created by
admin on Fri Dec 15 18:45:07 GMT 2023 , Edited by admin on Fri Dec 15 18:45:07 GMT 2023
|
PRIMARY | |||
|
100000083320
Created by
admin on Fri Dec 15 18:45:07 GMT 2023 , Edited by admin on Fri Dec 15 18:45:07 GMT 2023
|
PRIMARY | |||
|
6207
Created by
admin on Fri Dec 15 18:45:07 GMT 2023 , Edited by admin on Fri Dec 15 18:45:07 GMT 2023
|
PRIMARY | |||
|
C170255
Created by
admin on Fri Dec 15 18:45:07 GMT 2023 , Edited by admin on Fri Dec 15 18:45:07 GMT 2023
|
PRIMARY | |||
|
DB12637
Created by
admin on Fri Dec 15 18:45:07 GMT 2023 , Edited by admin on Fri Dec 15 18:45:07 GMT 2023
|
PRIMARY | |||
|
H6H7G23O3N
Created by
admin on Fri Dec 15 18:45:07 GMT 2023 , Edited by admin on Fri Dec 15 18:45:07 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
