BIDISOMIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C22H34ClN3O2
Molecular Weight	407.977
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)N(CCC(CCN1CCCCC1)(C(N)=O)C2=C(Cl)C=CC=C2)C(C)=O

InChI

InChIKey=GTEPPJFJSNSNIH-UHFFFAOYSA-N

InChI=1S/C22H34ClN3O2/c1-17(2)26(18(3)27)16-12-22(21(24)28,19-9-5-6-10-20(19)23)11-15-25-13-7-4-8-14-25/h5-6,9-10,17H,4,7-8,11-16H2,1-3H3,(H2,24,28)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11430469 | https://adisinsight.springer.com/drugs/800000174 |

Bidisomide (previously known as SC 40230) was developed as a sodium channel antagonist with class I antiarrhythmic properties. Bidisomide participated in clinical trials for patients with arrhythmia. However, the development was discontinued due to a lack of demonstrable efficacy.

Originator

Approval Year

PubMed

Title	Date	PubMed
Bidisomide (SC-40230), a new antiarrhythmic agent: initial study of tolerability and pharmacokinetics.	1992 Apr	1563207
Metabolism of a novel antiarrhythmic agent, bidisomide, in man: use of high resolution mass spectrometry to distinguish desisopropyl bidisomide from desacetyl bidisomide.	1995 Sep	8553691
Reduced systemic availability of an antiarrhythmic drug, bidisomide, with meal co-administration: relationship with region-dependent intestinal absorption.	1998 Feb	9523307
Mechanism of compound- and species-specific food effects of structurally related antiarrhythmic drugs, disopyramide and bidisomide.	1998 Mar	9563073
Electrophysiologic effects of an antiarrhythmic agent, bidisomide, on sodium current in isolated rat ventricular myocytes: comparison with mexiletine and disopyramide.	2001 May	11430469

Sample Use Guides

In Vivo Use Guide

Intravenous doses ranged from 0.03 to 2.5 mg/kg.

Route of Administration: Intravenous

Name

Type

Language

BIDISOMIDE

Official Name

English

BIDISOMIDE [MI]

Common Name

English

bidisomide [INN]

Common Name

English

BIDISOMIDE [USAN]

Common Name

English

1-PIPERIDINEBUTANAMIDE, .ALPHA.-(2-(ACETYL(1-METHYLETHYL)AMINO)ETHYL)-.ALPHA.-(2-CHLOROPHENYL)-, (±)-

Systematic Name

English

SC 40230

Code

English

SC-40230

Code

English

(±)-.ALPHA.-(O-CHLOROPHENYL)-.ALPHA.-(2-(N-ISOPROPYLACETAMIDO)ETHYL)-1-PIPERIDINEBUTYRAMIDE

Common Name

English

Code System Code Type Description

CAS

116078-65-0