U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 61 - 70 of 143 results

Status:
US Previously Marketed
Source:
Panzalone by Doak
(1961)
Source URL:
First approved in 1961
Source:
Panzalone by Doak
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)


Pregnenolone succinate is a synthetic pregnane steroid and an ester of pregnenolone which is described as a glucocorticoid and anti-inflammatory drug and has been patented and marketed as a topical medication in the form of a cream for the treatment of allergic, pruritic, and inflammatory dermatitis. In addition to its glucocorticoid effects, pregnenolone succinate has been found to act as a negative allosteric modulator of the GABAA receptor and a positive allosteric modulator of the NMDA receptor similarly to pregnenolone sulfate.
Dimethyl succinate is the inactive analog of dimethyl fumarate. Dimethyl succinate has a pleasant, ethereal, winey odor and a fruity, winey, and burning flavor. It is used in foods as a flavoring ingredient. Dimethyl succinate was found at increased concentrations in the culture medium of the lung cancer cell line A549 and in the urine of mice implanted with A549 cells. Dimethyl succinate could be used to prolong the insulinotropic action of GLP-1 in the treatment of type-2 diabetes and it may represent a novel therapeutic approach in endotoxemia and multiple-organ failure.
Status:
Possibly Marketed Outside US
Source:
Sallys Box Secret Garden Lemon Oil Ampoule Mask by Imine Co., Ltd
(2014)
Source URL:
First approved in 2014
Source:
Sallys Box Secret Garden Lemon Oil Ampoule Mask by Imine Co., Ltd
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Possibly Marketed Outside US
Source:
NCT00371826: Phase 4 Interventional Completed Renal Transplanted Recipients
(2006)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

11-keto methylprednisolone is a metabolite of corticosteroid immunosuppressant methylprednisolone.