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Details

Stereochemistry ACHIRAL
Molecular Formula C6H10O4
Molecular Weight 146.1412
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIMETHYL SUCCINATE

SMILES

COC(=O)CCC(=O)OC

InChI

InChIKey=MUXOBHXGJLMRAB-UHFFFAOYSA-N
InChI=1S/C6H10O4/c1-9-5(7)3-4-6(8)10-2/h3-4H2,1-2H3

HIDE SMILES / InChI

Description

Dimethyl succinate is the inactive analog of dimethyl fumarate. Dimethyl succinate has a pleasant, ethereal, winey odor and a fruity, winey, and burning flavor. It is used in foods as a flavoring ingredient. Dimethyl succinate was found at increased concentrations in the culture medium of the lung cancer cell line A549 and in the urine of mice implanted with A549 cells. Dimethyl succinate could be used to prolong the insulinotropic action of GLP-1 in the treatment of type-2 diabetes and it may represent a novel therapeutic approach in endotoxemia and multiple-organ failure.

Approval Year

2020
742
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
Activator
1430
Nasal mucosal carboxylesterase (Rat)
1
Target ID: Nasal mucosal carboxylesterase (Rat)
Substrate
661
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Preclinical
Unknown

Approved Use

Unknown
Primary
Preclinical
Unknown

Approved Use

Unknown
Preventing
Preclinical
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Patents

Patents

05639789
1
05728715
1
06080864
3
06909016
1
08263622
1
08703791
1
JP2000129030A
1
JP2000355636A
2
JP2001017276A
2
JP2002121518A
2
JP2003171635A
2
JP2003321586A
1
JP2005314632A
2
JP2011162759A
1
JPH00693293A
1
JPH01139537A
1
JPH0441442A
1
JPH093298A
1
JPH1036811A
2

Sample Use Guides

In Vivo Use Guide
Rat: 5.0 uM/g body weight
Route of Administration: Intraperitoneal
In Vitro Use Guide
alpha- and beta-D-glucose pentaacetate (1.7 mM each) augmented, to almost the same extent, insulin release caused by succinic acid dimethyl ester (10.0 mM) in rat pancreatic islets. The release of insulin provoked by succinic acid dimethyl ester was inhibited, however, by alpha-D-galactose pentaacetate, whilst being unaffected by beta-D-galactose pentaacetate (each also 1.7 mM).
Name Type Language
DIMETHYL SUCCINATE
FCC   FHFI   HSDB   INCI  
INCI  
Official Name English
DIMETHYL BUTANEDIOATE
Systematic Name English
BUTANEDIOIC ACID, DIMETHYL ESTER
Common Name English
SUCCINIC ACID, DIMETHYL ESTER
Common Name English
DIMETHYL SUCCINATE [FHFI]
Common Name English
BUTANEDIOIC ACID, 1,4-DIMETHYL ESTER
Common Name English
FEMA NO. 2396
Code English
SUCCINIC ACID DIMETHYL ESTER [MI]
Common Name English
DIMETHYL SUCCINATE [INCI]
Common Name English
SUCCINIC ACID DIMETHYL ESTER
MI  
Systematic Name English
NSC-52209
Code English
DIMETHYL SUCCINATE [FCC]
Common Name English
DIMETHYL SUCCINATE [HSDB]
Common Name English
Classification Tree Code System Code
Food Contact Sustance Notif, (FCN No.) FCN NO. 625
Created by admin on Fri Dec 15 17:22:51 GMT 2023 , Edited by admin on Fri Dec 15 17:22:51 GMT 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 670
Created by admin on Fri Dec 15 17:22:51 GMT 2023 , Edited by admin on Fri Dec 15 17:22:51 GMT 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 691
Created by admin on Fri Dec 15 17:22:51 GMT 2023 , Edited by admin on Fri Dec 15 17:22:51 GMT 2023
JECFA EVALUATION DIMETHYL SUCCINATE
Created by admin on Fri Dec 15 17:22:51 GMT 2023 , Edited by admin on Fri Dec 15 17:22:51 GMT 2023
CFR 21 CFR 172.515
Created by admin on Fri Dec 15 17:22:51 GMT 2023 , Edited by admin on Fri Dec 15 17:22:51 GMT 2023
Code System Code Type Description
HSDB
5370
Created by admin on Fri Dec 15 17:22:51 GMT 2023 , Edited by admin on Fri Dec 15 17:22:51 GMT 2023
PRIMARY
DAILYMED
914I2127JR
Created by admin on Fri Dec 15 17:22:51 GMT 2023 , Edited by admin on Fri Dec 15 17:22:51 GMT 2023
PRIMARY
FDA UNII
914I2127JR
Created by admin on Fri Dec 15 17:22:51 GMT 2023 , Edited by admin on Fri Dec 15 17:22:51 GMT 2023
PRIMARY
NSC
52209
Created by admin on Fri Dec 15 17:22:51 GMT 2023 , Edited by admin on Fri Dec 15 17:22:51 GMT 2023
PRIMARY
EPA CompTox
DTXSID5025152
Created by admin on Fri Dec 15 17:22:51 GMT 2023 , Edited by admin on Fri Dec 15 17:22:51 GMT 2023
PRIMARY
MESH
C056451
Created by admin on Fri Dec 15 17:22:51 GMT 2023 , Edited by admin on Fri Dec 15 17:22:51 GMT 2023
PRIMARY
EVMPD
SUB69286
Created by admin on Fri Dec 15 17:22:51 GMT 2023 , Edited by admin on Fri Dec 15 17:22:51 GMT 2023
PRIMARY
JECFA MONOGRAPH
1114
Created by admin on Fri Dec 15 17:22:51 GMT 2023 , Edited by admin on Fri Dec 15 17:22:51 GMT 2023
PRIMARY
ECHA (EC/EINECS)
203-419-9
Created by admin on Fri Dec 15 17:22:51 GMT 2023 , Edited by admin on Fri Dec 15 17:22:51 GMT 2023
PRIMARY
MERCK INDEX
m10269
Created by admin on Fri Dec 15 17:22:51 GMT 2023 , Edited by admin on Fri Dec 15 17:22:51 GMT 2023
PRIMARY Merck Index
CAS
106-65-0
Created by admin on Fri Dec 15 17:22:51 GMT 2023 , Edited by admin on Fri Dec 15 17:22:51 GMT 2023
PRIMARY
SMS_ID
100000135052
Created by admin on Fri Dec 15 17:22:52 GMT 2023 , Edited by admin on Fri Dec 15 17:22:52 GMT 2023
PRIMARY
RXCUI
2393581
Created by admin on Fri Dec 15 17:22:51 GMT 2023 , Edited by admin on Fri Dec 15 17:22:51 GMT 2023
PRIMARY
PUBCHEM
7820
Created by admin on Fri Dec 15 17:22:51 GMT 2023 , Edited by admin on Fri Dec 15 17:22:51 GMT 2023
PRIMARY
SUBSTANCE RECORD
Structure of DIMETHYL SUCCINATE
NIH
NCATS
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