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Restrict the search for
progesterone
to a specific field?
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
(+)-ZK 216348 is a selective nonsteroidal glucocorticoid receptor (GR) agonist. (+)-ZK 216348 shows anti-inflammatory activity comparable to prednisolone for both systemic and topical application. (+)-ZK 216348 showed no negative effects on intestinal epithelial migration or proliferation. This compound is a promising candidate for the treatment of acute inflammatory conditions. It was tested as a drug for the inflammatory bowel disease management.
Status:
Other
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Conditions:
3',5'-DICHLORO-2-HYDROXY-2-METHYLBUT-3-ENANILIDE is a metabolite of vinclozolin, a dicarboximide fungicide widely used in the United States and Europe for control of diseases caused by B. cineera, S. sclerotiorum, and Monilinia species in fruits, grapes, ornamental plants, turfgrass and vegetables. This fungicide possesses antiandrogenic activity. 3',5'-DICHLORO-2-HYDROXY-2-METHYLBUT-3-ENANILIDE has an antiandrogenic activity too. Moreover, it is an antagonist of progesterone, glucocorticoid, mineralocorticoid receptors and agonist for both estrogen receptors. This ability to act via more than one mechanism must be taken into consideration in the risk assessment process.
