Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C24H23F3N2O5 |
| Molecular Weight | 476.445 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=NOC(=O)C2=CC=C(NC(=O)C(O)(CC(C)(C)C3=C4OCCC4=CC=C3)C(F)(F)F)C=C12
InChI
InChIKey=VRZVKIJRJRBQJT-HSZRJFAPSA-N
InChI=1S/C24H23F3N2O5/c1-13-17-11-15(7-8-16(17)20(30)34-29-13)28-21(31)23(32,24(25,26)27)12-22(2,3)18-6-4-5-14-9-10-33-19(14)18/h4-8,11,32H,9-10,12H2,1-3H3,(H,28,31)/t23-/m1/s1
| Molecular Formula | C24H23F3N2O5 |
| Molecular Weight | 476.445 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/22235147
Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/22235147
(+)-ZK 216348 is a selective nonsteroidal glucocorticoid receptor (GR) agonist. (+)-ZK 216348 shows anti-inflammatory activity comparable to prednisolone for both systemic and topical application. (+)-ZK 216348 showed no negative effects on intestinal epithelial migration or proliferation. This compound is a promising candidate for the treatment of acute inflammatory conditions. It was tested as a drug for the inflammatory bowel disease management.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects. | 2004 Jan 6 |
|
| Effects of dissociated glucocorticoids on OPG and RANKL in osteoblastic cells. | 2006 May |
|
| Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists. | 2007 Sep 15 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:26:16 GMT 2023
by
admin
on
Sat Dec 16 11:26:16 GMT 2023
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| Record UNII |
8BY7XK862L
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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Common Name | English | ||
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Code | English | ||
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| Code System | Code | Type | Description | ||
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669073-68-1
Created by
admin on Sat Dec 16 11:26:16 GMT 2023 , Edited by admin on Sat Dec 16 11:26:16 GMT 2023
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NON-SPECIFIC STEREOCHEMISTRY | |||
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92293311
Created by
admin on Sat Dec 16 11:26:16 GMT 2023 , Edited by admin on Sat Dec 16 11:26:16 GMT 2023
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PRIMARY | |||
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8BY7XK862L
Created by
admin on Sat Dec 16 11:26:16 GMT 2023 , Edited by admin on Sat Dec 16 11:26:16 GMT 2023
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PRIMARY |
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ACTIVE MOIETY |
