U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 6541 - 6550 of 6711 results

Status:
US Previously Marketed
Source:
Trobicin by Upjohn
(1971)
Source URL:
First approved in 1971
Source:
Trobicin by Upjohn
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Spectinomycin is an antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of acute gonorrheal urethritis and proctitis in the male and acute gonorrheal cervicitis and proctitis in the female when due to susceptible strains of Neisseria gonorrhoeae. In vitro studies have shown spectinomycin to be active against most strains of Neisseria gonorrhoeae (minimum inhibitory concentration <7.5 to 20 mcg/mL). Footprint studies indicate that spectinomycin exerts regional effects on ribosomal structure. Spectinomycin hydrochloride is an inhibitor of protein synthesis in the bacterial cell; the site of action is the 30S ribosomal subunit. The antibiotic is not significantly bound to plasma protein. Spectinomycin was discovered 1961. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. This antibiotic is no longer available in the United States. Pfizer has discontinued distribution of spectinomycin (Trobicin) in the U.S. The drug continues to be distributed outside the U.S.
Status:
US Previously Marketed
Source:
Trobicin by Upjohn
(1971)
Source URL:
First approved in 1971
Source:
Trobicin by Upjohn
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Spectinomycin is an antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of acute gonorrheal urethritis and proctitis in the male and acute gonorrheal cervicitis and proctitis in the female when due to susceptible strains of Neisseria gonorrhoeae. In vitro studies have shown spectinomycin to be active against most strains of Neisseria gonorrhoeae (minimum inhibitory concentration <7.5 to 20 mcg/mL). Footprint studies indicate that spectinomycin exerts regional effects on ribosomal structure. Spectinomycin hydrochloride is an inhibitor of protein synthesis in the bacterial cell; the site of action is the 30S ribosomal subunit. The antibiotic is not significantly bound to plasma protein. Spectinomycin was discovered 1961. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. This antibiotic is no longer available in the United States. Pfizer has discontinued distribution of spectinomycin (Trobicin) in the U.S. The drug continues to be distributed outside the U.S.
Status:
US Previously Marketed
Source:
Trobicin by Upjohn
(1971)
Source URL:
First approved in 1971
Source:
Trobicin by Upjohn
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Spectinomycin is an antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of acute gonorrheal urethritis and proctitis in the male and acute gonorrheal cervicitis and proctitis in the female when due to susceptible strains of Neisseria gonorrhoeae. In vitro studies have shown spectinomycin to be active against most strains of Neisseria gonorrhoeae (minimum inhibitory concentration <7.5 to 20 mcg/mL). Footprint studies indicate that spectinomycin exerts regional effects on ribosomal structure. Spectinomycin hydrochloride is an inhibitor of protein synthesis in the bacterial cell; the site of action is the 30S ribosomal subunit. The antibiotic is not significantly bound to plasma protein. Spectinomycin was discovered 1961. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. This antibiotic is no longer available in the United States. Pfizer has discontinued distribution of spectinomycin (Trobicin) in the U.S. The drug continues to be distributed outside the U.S.
on as chelating agents in cosmetics. Pentasodium Pentetate is readily soluble in water, but the corresponding free acid is not. Pentasodium Pentetate is used in almost 400 cosmetic products over a wide range of product categories, although it is mostly used in hair dyes and colors at use concentrations of 0.1% to 1.0%. Pentetic Acid and Pentasodium Pentetate inactivate metallic ions, such as calcium and magnesium, to maintain stability and appearance of cosmetic products. The inactivation of other metallic ions such as iron or copper also helps to prevent the oxidative deterioration of cosmetics and personal care products.
Status:
US Previously Marketed
Source:
QUINTESS-N ATTAPULGITE by LILLY
(1962)
Source URL:
First approved in 1962
Source:
QUINTESS-N ATTAPULGITE by LILLY
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Attapulgite (magnesium aluminum phyllosilicate) is a clay mineral found in soils common to the Southeastern United States. It is widely used in medicine as an over-the-counter drug for the treatment of diarrhea. Attapulgite acts by physically binding to aacids and toxic substances in the stomach and digestive tract.
Status:
US Previously Marketed
Source:
Theratuss by Squibb
(1962)
Source URL:
First approved in 1962
Source:
Theratuss by Squibb
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

PIPAZETHATE is a non-narcotic oral antitussive agent. It acts centrally on the medullary cough center and is used for the treatment of cough.
Status:
US Previously Marketed
Source:
Timovan by Ayerst
(1960)
Source URL:
First approved in 1960
Source:
Timovan by Ayerst
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

PROTHIPENDYL is a neuroleptic azaphenothiazine used to treat anxiety and agitation in psychotic syndromes. It also shows strong antihistamine and anti-emetic actions.
Status:
US Previously Marketed
Source:
Timovan by Ayerst
(1960)
Source URL:
First approved in 1960
Source:
Timovan by Ayerst
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

PROTHIPENDYL is a neuroleptic azaphenothiazine used to treat anxiety and agitation in psychotic syndromes. It also shows strong antihistamine and anti-emetic actions.
Status:
US Previously Marketed
Source:
Adroyd by Parke-Davis
(1960)
Source URL:
First approved in 1960
Source:
Adroyd by Parke-Davis
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Oxymetholone (17beta-hydroxy-2-[hydroxymethylene]-17-methyl-5alpha-androstan-3-one) is a 17alpha-alkylated anabolic-androgenic steroid and a synthetic derivative of testosterone. It has been approved by the US Food and Drug Administration for the treatment of anemias caused by deficient red cell production. Acquired aplastic anemia, congenital aplastic anemia, myelofibrosis and the hypoplastic anemias due to the administration of myelotoxic drugs often respond. Drug interactions exist with cimetidine, paroxetine, and haloperidol, but are not expected with indinavir, ritonavir, clarithromycin, or itraconazole.
Status:
US Previously Marketed
Source:
Timovan by Ayerst
(1960)
Source URL:
First approved in 1960
Source:
Timovan by Ayerst
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

PROTHIPENDYL is a neuroleptic azaphenothiazine used to treat anxiety and agitation in psychotic syndromes. It also shows strong antihistamine and anti-emetic actions.

Showing 6541 - 6550 of 6711 results