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Details

Stereochemistry ACHIRAL
Molecular Formula C16H19N3S.ClH.H2O
Molecular Weight 339.883
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PROTHIPENDYL HYDROCHLORIDE MONOHYDRATE

SMILES

O.Cl.CN(C)CCCN1C2=C(SC3=C1N=CC=C3)C=CC=C2

InChI

InChIKey=YATJECIBCQMRMY-UHFFFAOYSA-N
InChI=1S/C16H19N3S.ClH.H2O/c1-18(2)11-6-12-19-13-7-3-4-8-14(13)20-15-9-5-10-17-16(15)19;;/h3-5,7-10H,6,11-12H2,1-2H3;1H;1H2

HIDE SMILES / InChI

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C16H19N3S
Molecular Weight 285.407
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

PROTHIPENDYL is a neuroleptic azaphenothiazine used to treat anxiety and agitation in psychotic syndromes. It also shows strong antihistamine and anti-emetic actions.

Approval Year

Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
18 ng/mL
40 mg single, oral
dose: 40 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PROTHIPENDYL serum
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
42.6 ng/mL
80 mg single, oral
dose: 80 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PROTHIPENDYL serum
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
2.5 h
unknown, oral
PROTHIPENDYL unknown
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
1280 mg 1 times / day multiple, oral
Studied dose
Dose: 1280 mg, 1 times / day
Route: oral
Route: multiple
Dose: 1280 mg, 1 times / day
Sources:
unhealthy, 20 years (range: 16-31 years)
n = 10
Health Status: unhealthy
Condition: long-standing behaviour disorders
Age Group: 20 years (range: 16-31 years)
Sex: M
Population Size: 10
Sources:
960 mg 1 times / day multiple, oral
Studied dose
Dose: 960 mg, 1 times / day
Route: oral
Route: multiple
Dose: 960 mg, 1 times / day
Sources:
unhealthy, 26 years (range: 14-42 years)
n = 10
Health Status: unhealthy
Condition: long-standing behaviour disorders
Age Group: 26 years (range: 14-42 years)
Sex: F
Population Size: 10
Sources:
4 g single, oral
Overdose
Dose: 4 g
Route: oral
Route: single
Dose: 4 g
Sources:
unknown
Health Status: unknown
Sources:
Other AEs: Adverse event...
Other AEs:
Adverse event (grade 5)
Sources:
AEs

AEs

AESignificanceDosePopulation
Adverse event grade 5
4 g single, oral
Overdose
Dose: 4 g
Route: oral
Route: single
Dose: 4 g
Sources:
unknown
Health Status: unknown
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG



OverviewOther

Other InhibitorOther SubstrateOther Inducer


Drug as victim
PubMed

PubMed

TitleDatePubMed
Different fatal toxicity of neuroleptics identified by autopsy.
2001 Apr
Fatal accident caused by isoflurane abuse.
2002 Dec
Increased D-amino acid oxidase expression in the bilateral hippocampal CA4 of schizophrenic patients: a post-mortem study.
2009 Dec
Psychotropic medication use among nursing home residents in Austria: a cross-sectional study.
2009 May 21
A double-blind, randomized, parallel group study to compare the efficacy, safety and tolerability of slow-release oral morphine versus methadone in opioid-dependent in-patients willing to undergo detoxification.
2009 Sep
Research on antipsychotics in India.
2010 Jan
The impact of perfectionism and anxiety traits on action monitoring in major depressive disorder.
2010 Jul
Substance Class Chemical
Created
by admin
on Sat Dec 16 06:42:34 GMT 2023
Edited
by admin
on Sat Dec 16 06:42:34 GMT 2023
Record UNII
9G1ILH80SA
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PROTHIPENDYL HYDROCHLORIDE MONOHYDRATE
Common Name English
PROTHIPENDYL HYDROCHLORIDE [MART.]
Common Name English
10H-PYRIDO(3,2-B)(1,4)BENZOTHIAZINE-10-PROPANAMINE, N,N-DIMETHYL-, HYDROCHLORIDE, HYDRATE (1:1:1)
Systematic Name English
Code System Code Type Description
SMS_ID
100000174884
Created by admin on Sat Dec 16 06:42:34 GMT 2023 , Edited by admin on Sat Dec 16 06:42:34 GMT 2023
PRIMARY
CAS
70145-94-7
Created by admin on Sat Dec 16 06:42:34 GMT 2023 , Edited by admin on Sat Dec 16 06:42:34 GMT 2023
PRIMARY
EPA CompTox
DTXSID80220426
Created by admin on Sat Dec 16 06:42:34 GMT 2023 , Edited by admin on Sat Dec 16 06:42:34 GMT 2023
PRIMARY
FDA UNII
9G1ILH80SA
Created by admin on Sat Dec 16 06:42:34 GMT 2023 , Edited by admin on Sat Dec 16 06:42:34 GMT 2023
PRIMARY
PUBCHEM
24844799
Created by admin on Sat Dec 16 06:42:34 GMT 2023 , Edited by admin on Sat Dec 16 06:42:34 GMT 2023
PRIMARY
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