SB239063 is a potent and selective p38 mitogen-activated protein kinase (p38 MAPK) alpha/beta inhibitor with IC50 of 44 nM, showing no activity against the gamma and delta kinase isoforms. SB 239063 is a potent inhibitor of inflammatory cytokine production, inhibits eosinophil recruitment, in addition to enhancing apoptosis of these cells and it can use for the treatment of asthma and other inflammatory disorders.