MAM-2201 has been recently detected in herbal products and has psychoactive and intoxicating effects in humans, suggesting that MAM-2201 alters brain function. MAM-2201 acts as an agonist of human cannabinoid receptor type 1 (CB1R) and thus to suppress neurotransmitter release. The reduction of neurotransmitter release from CB1R-containing synapses could contribute to some of the symptoms of synthetic cannabinoid intoxication including impairments in cerebellum-dependent motor coordination and motor learning.

QUCHIC or BB-22 (1-(cyclohexylmethyl)-8-quinolinyl ester-1H-indole-3-carboxylic acid), a quinoline derivative, is a synthetic cannabinoid. It is considered to be a constituent of illicit smoking mixtures "spice".