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3,3',5'-Triiodo-L-thyronine (also known as Reverse T3 (rT3)) is an inactive mirror-image of the active hormone T3. It is formed from T4 hormone and binds to T3 receptors, thus blocking the action of T3. The ratio of rT3 to T3 is a valuable biomarker of the metabolism and function of thyroid hormones. An elevated ratio of rT3 over T3 is a sign of “sick euthyroid” syndrome and helps to exclude a diagnosis of hypothyroidism, particularly in critically ill patients. The rT3 test is performed by ELISA method.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
AEW-541 is a pyrrolo[2,3-d]pyrimidine derivative small molecular weight kinase inhibitor of the IGF-IR IGF-1R/InsR with IC50 of 150 nM/140 nM in cell-free assays, greater potency and selectivity for IGF-1R in a cell-based assay. In vivo, this orally bioavailable compound inhibits IGF-IR signaling in tumor xenografts and significantly reduces the growth of IGF-IR-driven fibrosarcomas. AEW-541 represents a class of selective, small molecule IGF-IR kinase inhibitors with proven in vivo antitumor activity and potential therapeutic application.
