Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C15H12I3NO4 |
| Molecular Weight | 650.9735 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
N[C@@H](CC1=CC=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)C(O)=O
InChI
InChIKey=HZCBWYNLGPIQRK-LBPRGKRZSA-N
InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1
| Molecular Formula | C15H12I3NO4 |
| Molecular Weight | 650.9735 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
3,3',5'-Triiodo-L-thyronine (also known as Reverse T3 (rT3)) is an inactive mirror-image of the active hormone T3. It is formed from T4 hormone and binds to T3 receptors, thus blocking the action of T3. The ratio of rT3 to T3 is a valuable biomarker of the metabolism and function of thyroid hormones. An elevated ratio of rT3 over T3 is a sign of “sick euthyroid” syndrome and helps to exclude a diagnosis of hypothyroidism, particularly in critically ill patients. The rT3 test is performed by ELISA method.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Permanent atrial fibrillation in heart failure patients as another condition with increased reverse triiodothyronine concentration. | 2016 Sep |
|
| Permanent atrial fibrillation in heart failure patients as another condition with increased reverse triiodothyronine concentration. | 2016 Sep |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:58:09 GMT 2023
by
admin
on
Sat Dec 16 10:58:09 GMT 2023
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| Record UNII |
8NZ4Y08T96
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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| Code System | Code | Type | Description | ||
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REVERSE TRIIODOTHYRONINE
Created by
admin on Sat Dec 16 10:58:09 GMT 2023 , Edited by admin on Sat Dec 16 10:58:09 GMT 2023
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8NZ4Y08T96
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11684
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644280
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28774
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5817-39-0
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57261
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DTXSID3046908
Created by
admin on Sat Dec 16 10:58:09 GMT 2023 , Edited by admin on Sat Dec 16 10:58:09 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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TRANSPORTER -> SUBSTRATE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> IMPURITY |
UNSPECIFIED
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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