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Restrict the search for
m cariprazine
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Class (Stereo):
CHEMICAL (RACEMIC)
Metaterol is a beta-adrenoceptor agonist. It exerts sympathomimetic and broncholytic properties.
Status:
Investigational
Source:
NCT00538343: Phase 2 Interventional Terminated Brain Metastases
(2007)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Berubicin, an anthracycline derivative, is a DNA binding agent and potent topoisomerase II poison. Reata Pharmaceuticals were developing it as a treatment for brain cancer as it can breach the blood-brain barrier. It had also been in early clinical trials for the treatment of lung cancer and malignant gliomas. However, studies have been terminated. In October 2006, it was granted orphan drug designation from the FDA for the treatment of malignant gliomas. According to a CNS Pharmaceuticals media release in April 2018, berubicin will be studied for glioblastoma patients, these investigations will be funded in part by an equity crowdfunding campaign.
Status:
Investigational
Source:
NCT00959881: Phase 1 Interventional Completed Healthy Subjects
(2009)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Begacestat (GSI-953 or PF-5212362), a gamma-secretase inhibitor (GSI) that selectively inhibits cleavage of APP over Notch, was discovered for the treatment of Alzheimer's disease. The drug has shown promise results in phase I clinical trials, however further studies were discontinued.
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
NCT03762031: Phase 1 Interventional Completed Healthy
(2019)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
M40419 (now GC4419) is a Mn(II)-containing pentaazamacrocyclic selective superoxide dismutase mimetic. It is a first-in-class, small molecule enzyme mimetic that converts superoxide to hydrogen peroxide and molecular oxygen. GC4419 is currently being evaluated in an ongoing randomized Phase 2 clinical trial to assess its effect on the incidence, severity and duration of severe oral mucositis (OM) when given to patients with squamous cell cancers of the head and neck in combination with radiation and chemotherapy. GC4419 has received Breakthrough Therapy and Fast Track designations from the U.S. Food and Drug Administration.
Class (Stereo):
CHEMICAL (ACHIRAL)
Class (Stereo):
CHEMICAL (ABSOLUTE)
LANPROSTON is an analog of prostaglandin F2 alpha. It is used as veterinary medicament.
Class (Stereo):
CHEMICAL (ACHIRAL)
LAMTIDINE is an irreversible and specific gastric histamine H2-receptor antagonist.
Class (Stereo):
CHEMICAL (ACHIRAL)
Colfenamate is an antypyretic and antiinflammatory compound developed by the German company Tropon, GmbH.
Class (Stereo):
CHEMICAL (MIXED)
Iodetryl is fatty acid derivative patented by Russian company OOO "Nauchno-Proizvodstvennaya Firma "I. M. A." as a colloidal contrast agent.
