Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C18H28N6O |
| Molecular Weight | 344.4545 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1N=C(N)N=C1NCCCOC2=CC(CN3CCCCC3)=CC=C2
InChI
InChIKey=NRIGRKAXOLMTSK-UHFFFAOYSA-N
InChI=1S/C18H28N6O/c1-23-18(21-17(19)22-23)20-9-6-12-25-16-8-5-7-15(13-16)14-24-10-3-2-4-11-24/h5,7-8,13H,2-4,6,9-12,14H2,1H3,(H3,19,20,21,22)
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Comparison of antisecretory potency and duration of action of the H2-receptor antagonists AH 22216, cimetidine, ranitidine and SK & F 93479 in the dog. | 1983 Apr |
|
| Irreversible and specific inactivation by AH 22216 of histamine H2 receptors in the human gastric cancer cell line HGT-1. | 1983 Oct 14 |
|
| Potent and specific blockade by AH 22216 of histamine-H2-receptor-mediated acid secretion in isolated rabbit gastric cells. | 1983 Sep |
Patents
Sample Use Guides
The actions of LAMTIDINE (AH 22216) and cimetidine on the receptor-cAMP systems sensitive to histamine and the vasoactive intestinal peptide (VIP) in the human gastric cancer cell line HGT-1 were compared. When added simultaneously with histamine (10^-4 M), the potency of AH 22216 is similar to that of cimetidine (IC50 = 4-6.6*10^-6 M, respectively). Schild plot analysis indicated a non-competitive inhibition by AH 22216 (pA2 = 6.22, slope = 1.4 +/- 0.03). Preincubations of AH 22216 (10 min, 10^-5 M) with HGT-1 cells (even after a washout period) resulted in a complete and persistent (60 min) inactivation of the subsequent histamine effect, without changing the kinetics of the VIP-induced stimulation in the system.
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NCI_THESAURUS |
C29702
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100000082532
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C79118
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CHEMBL2105110
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SUB08394MIG
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ACTIVE MOIETY
