Glipalamide (Glipolamid) is a hypoglycemic agent and part of the second-generation sulfonamide derivatives. These sulphonylureas are used as medication to control blood sugar levels in patients with diabetes type 2. Like other sulphonylureas, glipalamide exerts extra-pancreatic activity. The antihyperglycemic action of this compound (and other sulphonylureas) may be explained by increased affinity of insulin receptors and the stimulating action of these compounds on peripheral glucose metabolism. Glipalamide was analyzed for its physical-chemical properties. After oral administration in animals, no differences were observed in insulin concentration between experimental and control groups, despite a significant fall in blood glucose level.

Halethazole has been studied as an active antifungal compound.

Nonathymulin (Thymulin, FTS) is well defined nonapeptide hormone produced by thymic epithelial cells. Its biological activity and antigenicity depend upon the presence of the metal zinc in the molecule. Thymulin consists of a biologically inactive nonapeptide component termed FTS (anacronym for serum thymus factor in French) coupled in an equimolecular ratio to the ion zinc, which confers biological activity to the molecule. This pharmacologically active metallopeptide induces the differentiation of T-cells and enhances several functions of the various T-cell subsets in normal or partially thymus-deficient recipients. The peptide is a natural hormone, available in synthetic form. Thymulin has a selective immunomodulatory effect, enhancing anti-inflammatory and inhibiting pro-inflammatory cytokines. It suppresses p38 (implicated in glucocorticoid-resistance) and inhibits NF-kappaB activation, which has an important pathogenic role in several lung diseases. The broad spectrum of anti-inflammatory effects of this peptide in several animal models of lung disease makes thymulin a good candidate for future clinical trials. Thymulin was being investigated by Santen Pharmaceutical in Japan. Its development for the treatment of ischaemic heart disorders and rheumatoid arthritis in Japan was discontinued. Thymulin is probably the best characterized of all putative thymic hormones and seems to playa physiological role in thymus–pituitary communication, particularly during perinatal life. Interest in the therapeutic use of thymulin flourished during the 1970s and 1980s when efforts were almost exclusively focused on using thymulin for the treatment of autoimmune and other immunopathologies as well as cancer. Subsequent studies established that thymulin is active on the hypophysis and the brain. This awareness and the availability of a synthetic gene for metFTS have opened new avenues for the exploration and eventual exploitation of the therapeutic potential of this metallopeptide.

Benzquercin is a member of flavones. Experiments on mice have shown that compound decreased morphological disorders of the connective tissue of lathyritic mice and the vascular permeability was close to normal controls.

Oxyridazine was developed as a neuroleptic agent. However, information about the further development of this drug is not available.

Acefurtiamine is a vitamin B1 analog. It is as an analgesic.

Isamoltan (CGP 361A) is a β-adrenoceptor and serotonin 1B receptor antagonist. Isamoltane has reported activity as an anxiolytic in man. Isamoltan had been in phase III clinical trials for the treatment of anxiety. However, this research has been discontinued.

MK-0354 is a GPR109a (Niacin receptor 1) agonist, originated by Arena Pharmaceuticals. In phase II of clinical trials against dyslipidemia treatment with MK-0354 failed to produce changes in high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, or triglycerides.

Topterone is an anti-androgen agent. Topterone inhibited stimulation of flank organ development of castrated immature male hamsters by both testosterone and dihydrotestosterone. Topical application of topterone on the flank organs of the male hamster did not cause any significant effect on testosterone metabolism of this tissue. In addition, there was no decrease in the lipogenic capacity of the flank organ. Topterone exerts its antiandrogenic action by binding with the cytosolic androgen receptor(s) in the flank organ thus inhibiting the action of dihydrotestosterone. Systemic administration demonstrated that topterone was both antiandrogenic and progestational. Topterone produced a mean inhibition of sebum excretion of 20% when it was applied topically for four weeks to the forehead skin of patients with acne.

Flumoxonide, an acetal derivative, is a synthetic glucocorticoid corticosteroid, it is an antiinflammatory agent for topical use.